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    Rac1 Rac family small GTPase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363875, updated on 10-Jul-2024

    Summary

    Official Symbol
    Rac1provided by RGD
    Official Full Name
    Rac family small GTPase 1provided by RGD
    Primary source
    RGD:619755
    See related
    EnsemblRapid:ENSRNOG00000001068 AllianceGenome:RGD:619755
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including GTP binding activity; Rho GDP-dissociation inhibitor binding activity; and enzyme binding activity. Involved in several processes, including Rac protein signal transduction; bone resorption; and regulation of cellular biosynthetic process. Located in several cellular components, including Golgi membrane; cytosol; and dendritic spine. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 434.0), Spleen (RPKM 368.1) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rac1 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16150411..16170864)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11037028..11057251)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13090316..13111841)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 42 Neighboring gene cytohesin 3 Neighboring gene small integral membrane protein 10 like 3 Neighboring gene family with sequence similarity 220, member A Neighboring gene diacylglycerol lipase, beta Neighboring gene KDEL endoplasmic reticulum protein retention receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables G protein activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Rho GDP-dissociation inhibitor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thioesterase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Rac protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Rac protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within anatomical structure arrangement ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiotensin-activated signaling pathway involved in heart process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within auditory receptor cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone resorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex GABAergic interneuron development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebral cortex radially oriented cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cochlea morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic olfactory bulb interneuron precursor migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in engulfment of apoptotic cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in engulfment of apoptotic cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in enzyme-linked receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within erythrocyte enucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in forebrain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hyperosmotic response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within interneuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in localization within membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in localization within membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mast cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbrain dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-23 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-23 production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic actin cytoskeleton organization EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in postsynaptic actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ERK5 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell adhesion involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neutrophil migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of nitric oxide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of respiratory burst IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ruffle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in semaphorin-plexin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sphingosine-1-phosphate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingosine-1-phosphate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinocilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related C3 botulinum toxin substrate 1
    Names
    p21-Rac1
    ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
    rho family, small GTP binding protein Rac1
    NP_599193.1
    XP_063127624.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134366.1NP_599193.1  ras-related C3 botulinum toxin substrate 1

      See identical proteins and their annotated locations for NP_599193.1

      Status: PROVISIONAL

      Source sequence(s)
      AY491395
      UniProtKB/Swiss-Prot
      Q6RUV5
      UniProtKB/TrEMBL
      A0A0G2K0X4, A6K1K8
      Related
      ENSRNOP00000075900.3, ENSRNOT00000092558.3
      Conserved Domains (1) summary
      cd01871
      Location:3176
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      16150411..16170864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271554.1XP_063127624.1  ras-related C3 botulinum toxin substrate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G820