Format

Send to:

Choose Destination
    • Showing Current items.

    ILK integrin linked kinase [ Homo sapiens (human) ]

    Gene ID: 3611, updated on 3-Jan-2021

    Summary

    Official Symbol
    ILKprovided by HGNC
    Official Full Name
    integrin linked kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6040
    See related
    Ensembl:ENSG00000166333 MIM:602366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P59; ILK-1; ILK-2; p59ILK; HEL-S-28
    Summary
    This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Data Table view

    Genomic context

    See ILK in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6603748..6610873)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6624938..6632105)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8 Neighboring gene Sharpr-MPRA regulatory region 730 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686F1765

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell junction assembly TAS
    Traceable Author Statement
    more info
     
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet aggregation HMP PubMed 
    positive regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    focal adhesion HDA PubMed 
    focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    sarcomere IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    integrin-linked protein kinase
    Names
    59 kDa serine/threonine-protein kinase
    epididymis secretory protein Li 28
    integrin-linked kinase-2
    NP_001014794.1
    NP_001014795.1
    NP_001265370.1
    NP_001265371.1
    NP_004508.1
    XP_005252961.1
    XP_005252962.1
    XP_011518367.1
    XP_016873161.1
    XP_024304262.1
    XP_024304263.1
    XP_024304264.1
    XP_024304265.1
    XP_024304266.1
    XP_024304267.1
    XP_024304268.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Data Table view

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029702.1 RefSeqGene

      Range
      4975..12142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_444

    mRNA and Protein(s)

    1. NM_001014794.3NP_001014794.1  integrin-linked protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001014794.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      BC001554, DC380243, HY257434, U40282
      Consensus CDS
      CCDS7768.1
      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Related
      ENSP00000403487.2, ENST00000420936.6
      Conserved Domains (4) summary
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:38124
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:454
      Ank_4; Ankyrin repeats (many copies)
    2. NM_001014795.3NP_001014795.1  integrin-linked protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001014795.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AC091564, CR749220, DC379936, HY257434, U40282
      Consensus CDS
      CCDS7768.1
      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Related
      ENSP00000379975.2, ENST00000396751.6
      Conserved Domains (4) summary
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:38124
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:454
      Ank_4; Ankyrin repeats (many copies)
    3. NM_001278441.2NP_001265370.1  integrin-linked protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001265370.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons in the coding region, which results in a section that contains a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC091564, AK296628, DC380243, HY257434, U40282
      Consensus CDS
      CCDS60712.1
      UniProtKB/Swiss-Prot
      Q13418
      Related
      ENSP00000435323.1, ENST00000528995.5
      Conserved Domains (3) summary
      cd00204
      Location:28117
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:144388
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    4. NM_001278442.2NP_001265371.1  integrin-linked protein kinase isoform 3

      See identical proteins and their annotated locations for NP_001265371.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks an exon in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK293474
      Consensus CDS
      CCDS60713.1
      UniProtKB/Swiss-Prot
      Q13418
      Related
      ENSP00000434492.2, ENST00000532063.5
      Conserved Domains (1) summary
      cd14057
      Location:63315
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    5. NM_004517.4NP_004508.1  integrin-linked protein kinase isoform 1

      See identical proteins and their annotated locations for NP_004508.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      DC380243, HY257434, U40282
      Consensus CDS
      CCDS7768.1
      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Related
      ENSP00000299421.3, ENST00000299421.8
      Conserved Domains (4) summary
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:38124
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:454
      Ank_4; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      6603748..6610873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448499.1XP_024304267.1  integrin-linked protein kinase isoform X3

      Conserved Domains (3) summary
      cd14057
      Location:146398
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:1546
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:273
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_017017672.1XP_016873161.1  integrin-linked protein kinase isoform X3

      Conserved Domains (3) summary
      cd14057
      Location:146398
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:1546
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:273
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_005252904.5XP_005252961.1  integrin-linked protein kinase isoform X2

      See identical proteins and their annotated locations for XP_005252961.1

      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Conserved Domains (4) summary
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:38124
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:454
      Ank_4; Ankyrin repeats (many copies)
    4. XM_024448495.1XP_024304263.1  integrin-linked protein kinase isoform X1

      Related
      ENST00000530016.5
      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:228480
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    5. XM_024448494.1XP_024304262.1  integrin-linked protein kinase isoform X1

      Related
      ENSP00000439606.2, ENST00000537806.5
      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:228480
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    6. XM_024448498.1XP_024304266.1  integrin-linked protein kinase isoform X3

      Conserved Domains (3) summary
      cd14057
      Location:146398
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:1546
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:273
      Ank_2; Ankyrin repeats (3 copies)
    7. XM_024448500.1XP_024304268.1  integrin-linked protein kinase isoform X4

      Conserved Domains (1) summary
      cd14057
      Location:94346
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    8. XM_005252905.3XP_005252962.1  integrin-linked protein kinase isoform X5

      See identical proteins and their annotated locations for XP_005252962.1

      UniProtKB/Swiss-Prot
      Q13418
      Conserved Domains (1) summary
      cd14057
      Location:63315
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    9. XM_024448496.1XP_024304264.1  integrin-linked protein kinase isoform X1

      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:228480
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    10. XM_011520065.1XP_011518367.1  integrin-linked protein kinase isoform X2

      See identical proteins and their annotated locations for XP_011518367.1

      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Conserved Domains (4) summary
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:38124
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:454
      Ank_4; Ankyrin repeats (many copies)
    11. XM_024448497.1XP_024304265.1  integrin-linked protein kinase isoform X1

      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:228480
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    Support Center