ILK integrin linked kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: ILKprovided by HGNC
Official Full Name: integrin linked kinaseprovided by HGNC
Primary source: HGNC:HGNC:6040
See related: Ensembl:ENSG00000166333 MIM:602366
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P59; ILK-1; ILK-2; p59ILK; HEL-S-28
Summary: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression: Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 11p15.4

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	11	NC_000011.10 (6603708..6610874)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (6624938..6632105)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Lipoxin A4 and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis.
Title: Lipoxin A<sub>4</sub> and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis.
epithelial mesenchymal transition significantly contributes to phyllodes tumor pathogenesis and implicates ILK and ZEB1 in phyllodes tumors malignant phenotype
Title: Expression of EMT inducers integrin-linked kinase (ILK) and ZEB1 in phyllodes breast tumors is associated with aggressive phenotype.
By recruiting focal adhesions adaptors PINCH and Parvin into a heterotrimeric complex, integrin linked kinase (ILK) triggers F-actin filament bundling, generating a force/mechanical signal to promote cytoskeleton reassembly and dynamic cell adhesion. The process is sensitized to Mg-ATP bound to the pseudoactive site of ILK and its dysregulation severely impairs stress fibers formation, cell spreading, and migration.
Title: Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion.
Using molecular modeling and molecular dynamics simulations, we show that Asp344, Asp352, and Thr356 in kindlin-2 and Arg243 and Arg334 in ILK kinase domain (KD) are important in kindlin-2/ILK complex formation. Mutations that disrupt these interactions abrogate kindlin-2 and ILK colocalization in HeLa cells.
Title: The binding interface of kindlin-2 and ILK involves Asp344/Asp352/Thr356 in kindlin-2 and Arg243/Arg334 in ILK.
High ILK expression is associated with Neuroblastoma.
Title: Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.
We further performed molecular dynamics simulation for 100ns to see the effect of urea on structural stability of kinase domain of ILK at atomic level. Structural changes with increasing concentrations of urea were analysed, and we observed a significant increase in the root mean square deviation, root mean square fluctuations, solvent accessible surface area and radius of gyration
Title: Mechanistic insights into the urea-induced denaturation of kinase domain of human integrin linked kinase.
ILK overexpression in human CRC associates with EMT and CSC traits, contributing to tumor progression and chemoresistance.
Title: ILK Expression in Colorectal Cancer Is Associated with EMT, Cancer Stem Cell Markers and Chemoresistance.
Dermal fibroblast-to-myofibroblast transition sustained by alphavss3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders.
Title: Dermal fibroblast-to-myofibroblast transition sustained by αvß3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders.
These results indicated that ILK promoted cell proliferation and growth in breast cancer cells through activation of the PI3K/Akt pathway.
Title: ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway.
ILK-induced epithelial-mesenchymal transition is a novel mechanism in the pathogenesis of adenomyosis
Title: ILK-induced epithelial-mesenchymal transition promotes the invasive phenotype in adenomyosis.

Submit: New GeneRIF Correction See all GeneRIFs (215)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
Cell junction organization, organism-specific biosystem (from REACTOME)
Cell junction organization, organism-specific biosystem
Cell junction organization
Cell-Cell communication, organism-specific biosystem (from REACTOME)
Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
Cell-extracellular matrix interactions, organism-specific biosystem (from REACTOME)
Cell-extracellular matrix interactions, organism-specific biosystemCell-extracellular matrix (ECM) interactions play a critical role in regulating a variety of cellular processes in multicellular organisms including motility, shape change, survival, proliferation an...
Endometrial cancer, organism-specific biosystem (from KEGG)
Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
Endometrial cancer, conserved biosystem (from KEGG)
Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
Eukaryotic Transcription Initiation, organism-specific biosystem (from WikiPathways)
Eukaryotic Transcription Initiation, organism-specific biosystemIn eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the pre...
Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystem (from WikiPathways)
Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystemThe signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth...
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
Integrins in angiogenesis, organism-specific biosystem
Integrins in angiogenesis
Localization of the PINCH-ILK-PARVIN complex to focal adhesions, organism-specific biosystem (from REACTOME)
Localization of the PINCH-ILK-PARVIN complex to focal adhesions, organism-specific biosystemThe interactions among ILK, PINCH, and parvins are necessary but not sufficient for localization of ILK to cell-ECM adhesions (Zhang et al., 2002). Additional proteins that interact with PINCH-IL...
Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
Osteopontin-mediated events, organism-specific biosystem
Osteopontin-mediated events
PPAR signaling pathway, organism-specific biosystem (from KEGG)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, conserved biosystem (from KEGG)
PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

WI-22555 (e-PCR)
- UniSTS:5777

RH12375 (e-PCR)
- UniSTS:23970

WI-12713 (e-PCR)
- UniSTS:10454

A002C40 (e-PCR)
- UniSTS:5081

KS608 (e-PCR)
- UniSTS:253179

Homology

Homologs of the ILK gene: The ILK gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 231 organisms have orthologs with human gene ILK
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
SH3 domain binding	IEA Inferred from Electronic Annotation more info
integrin binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
cell aging	IEA Inferred from Electronic Annotation more info
cell cycle arrest	IEA Inferred from Electronic Annotation more info
cell junction assembly	TAS Traceable Author Statement more info
cell proliferation	NAS Non-traceable Author Statement more info	PubMed
cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
establishment or maintenance of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
fibroblast migration	IEA Inferred from Electronic Annotation more info
integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
myelin assembly	IEA Inferred from Electronic Annotation more info
myelination in peripheral nervous system	IEA Inferred from Electronic Annotation more info
negative regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of protein kinase activity	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
nerve development	IEA Inferred from Electronic Annotation more info
neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
platelet aggregation	HMP more info	PubMed
positive regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
positive regulation of NIK/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of axon extension	IEA Inferred from Electronic Annotation more info
positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
positive regulation of dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of protein kinase B signaling	IEA Inferred from Electronic Annotation more info
positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-templated	IMP Inferred from Mutant Phenotype more info	PubMed
protein heterooligomerization	IEA Inferred from Electronic Annotation more info
protein kinase B signaling	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info	PubMed
substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
supramolecular fiber organization	IEA Inferred from Electronic Annotation more info
tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cell junction	IDA Inferred from Direct Assay more info
cell-cell junction	IEA Inferred from Electronic Annotation more info
costamere	IEA Inferred from Electronic Annotation more info
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
dendritic shaft	IEA Inferred from Electronic Annotation more info
focal adhesion	HDA more info	PubMed
focal adhesion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
focal adhesion	IDA Inferred from Direct Assay more info
lamellipodium	IEA Inferred from Electronic Annotation more info
membrane	HDA more info	PubMed
neuronal cell body	IEA Inferred from Electronic Annotation more info
nucleoplasm	IDA Inferred from Direct Assay more info
plasma membrane	IEA Inferred from Electronic Annotation more info
protein-containing complex	IEA Inferred from Electronic Annotation more info
sarcomere	IEA Inferred from Electronic Annotation more info
colocalizes_with stress fiber	IBA Inferred from Biological aspect of Ancestor more info	PubMed
terminal bouton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin-linked protein kinase

Names: 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integrin-linked kinase-2

NP_001014794.1

EC 2.7.11.1

NP_001014795.1

EC 2.7.11.1

NP_001265370.1

EC 2.7.11.1

NP_001265371.1

EC 2.7.11.1

NP_004508.1

EC 2.7.11.1

XP_005252961.1

EC 2.7.11.1

XP_005252962.1

EC 2.7.11.1

XP_011518367.1

EC 2.7.11.1

XP_016873161.1

EC 2.7.11.1

XP_024304262.1

EC 2.7.11.1

XP_024304263.1

EC 2.7.11.1

XP_024304264.1

EC 2.7.11.1

XP_024304265.1

EC 2.7.11.1

XP_024304266.1

EC 2.7.11.1

XP_024304267.1

EC 2.7.11.1

XP_024304268.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029702.1 RefSeqGene

Range

4975..12142

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_444

mRNA and Protein(s)

NM_001014794.2 → NP_001014794.1 integrin-linked protein kinase isoform 1

See identical proteins and their annotated locations for NP_001014794.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

BC001554, DC380243, HY257434, U40282

Consensus CDS

CCDS7768.1

UniProtKB/Swiss-Prot

Q13418

UniProtKB/TrEMBL

V9HWF0

Related

ENSP00000403487.2, ENST00000420936.6

Conserved Domains (3) summary

cd00204
Location:28 → 140

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]
NM_001014795.2 → NP_001014795.1 integrin-linked protein kinase isoform 1

See identical proteins and their annotated locations for NP_001014795.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

CR749220, DC379936, HY257434, U40282

Consensus CDS

CCDS7768.1

UniProtKB/Swiss-Prot

Q13418

UniProtKB/TrEMBL

V9HWF0

Related

ENSP00000379975.2, ENST00000396751.6

Conserved Domains (3) summary

cd00204
Location:28 → 140

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]
NM_001278441.1 → NP_001265370.1 integrin-linked protein kinase isoform 2

See identical proteins and their annotated locations for NP_001265370.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate exons in the coding region, which results in a section that contains a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC091564, AK296628, DC380243, HY257434, U40282

Consensus CDS

CCDS60712.1

UniProtKB/Swiss-Prot

Q13418

Related

ENSP00000435323.1, ENST00000528995.5

Conserved Domains (3) summary

cd00204
Location:28 → 117

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:144 → 388

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]
NM_001278442.1 → NP_001265371.1 integrin-linked protein kinase isoform 3

See identical proteins and their annotated locations for NP_001265371.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks an exon in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK293474, DC380243, HY257434

Consensus CDS

CCDS60713.1

UniProtKB/Swiss-Prot

Q13418

Related

ENSP00000434492.2, ENST00000532063.5

Conserved Domains (1) summary

cd14057
Location:63 → 315

PK_ILK; Pseudokinase domain of Integrin Linked Kinase
NM_004517.3 → NP_004508.1 integrin-linked protein kinase isoform 1

See identical proteins and their annotated locations for NP_004508.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

DC380243, HY257434, U40282

Consensus CDS

CCDS7768.1

UniProtKB/Swiss-Prot

Q13418

UniProtKB/TrEMBL

V9HWF0

Related

ENSP00000299421.3, ENST00000299421.8

Conserved Domains (3) summary

cd00204
Location:28 → 140

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p12 Primary Assembly

Range

6603708..6610874

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024448499.1 → XP_024304267.1 integrin-linked protein kinase isoform X3
XM_017017672.1 → XP_016873161.1 integrin-linked protein kinase isoform X3

Conserved Domains (3) summary

cd00204
Location:2 → 89

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:146 → 398

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:15 → 46

ANK; ANK repeat [structural motif]
XM_005252904.5 → XP_005252961.1 integrin-linked protein kinase isoform X2

See identical proteins and their annotated locations for XP_005252961.1

UniProtKB/Swiss-Prot

Q13418

UniProtKB/TrEMBL

V9HWF0

Conserved Domains (3) summary

cd00204
Location:28 → 140

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]
XM_024448495.1 → XP_024304263.1 integrin-linked protein kinase isoform X1

Conserved Domains (3) summary

cd00204
Location:28 → 140

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:228 → 480

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]
XM_024448494.1 → XP_024304262.1 integrin-linked protein kinase isoform X1

Related

ENSP00000439606.2, ENST00000537806.5

Conserved Domains (3) summary

cd00204
Location:28 → 140

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:228 → 480

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]
XM_024448498.1 → XP_024304266.1 integrin-linked protein kinase isoform X3
XM_024448500.1 → XP_024304268.1 integrin-linked protein kinase isoform X4

Conserved Domains (1) summary

cd14057
Location:94 → 346

PK_ILK; Pseudokinase domain of Integrin Linked Kinase
XM_005252905.3 → XP_005252962.1 integrin-linked protein kinase isoform X5

See identical proteins and their annotated locations for XP_005252962.1

UniProtKB/Swiss-Prot

Q13418

Conserved Domains (1) summary

cd14057
Location:63 → 315

PK_ILK; Pseudokinase domain of Integrin Linked Kinase
XM_024448496.1 → XP_024304264.1 integrin-linked protein kinase isoform X1

Conserved Domains (3) summary

cd00204
Location:28 → 140

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:228 → 480

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]
XM_011520065.1 → XP_011518367.1 integrin-linked protein kinase isoform X2

See identical proteins and their annotated locations for XP_011518367.1

UniProtKB/Swiss-Prot

Q13418

UniProtKB/TrEMBL

V9HWF0

Conserved Domains (3) summary

cd00204
Location:28 → 140

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:197 → 449

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]
XM_024448497.1 → XP_024304265.1 integrin-linked protein kinase isoform X1

Conserved Domains (3) summary

cd00204
Location:28 → 140

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14057
Location:228 → 480

PK_ILK; Pseudokinase domain of Integrin Linked Kinase

sd00045
Location:33 → 64

ANK; ANK repeat [structural motif]