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    ILK integrin linked kinase [ Homo sapiens (human) ]

    Gene ID: 3611, updated on 13-Feb-2019

    Summary

    Official Symbol
    ILKprovided by HGNC
    Official Full Name
    integrin linked kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6040
    See related
    Ensembl:ENSG00000166333 MIM:602366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P59; ILK-1; ILK-2; p59ILK; HEL-S-28
    Summary
    This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See ILK in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (6603708..6610874)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6624938..6632105)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8 Neighboring gene uncharacterized LOC107984305 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-extracellular matrix interactions, organism-specific biosystem (from REACTOME)
      Cell-extracellular matrix interactions, organism-specific biosystemCell-extracellular matrix (ECM) interactions play a critical role in regulating a variety of cellular processes in multicellular organisms including motility, shape change, survival, proliferation an...
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Eukaryotic Transcription Initiation, organism-specific biosystem (from WikiPathways)
      Eukaryotic Transcription Initiation, organism-specific biosystemIn eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the pre...
    • Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystem (from WikiPathways)
      Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystemThe signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
      Integrins in angiogenesis, organism-specific biosystem
      Integrins in angiogenesis
    • Localization of the PINCH-ILK-PARVIN complex to focal adhesions, organism-specific biosystem (from REACTOME)
      Localization of the PINCH-ILK-PARVIN complex to focal adhesions, organism-specific biosystemThe interactions among ILK, PINCH, and parvins are necessary but not sufficient for localization of ILK to cell-ECM adhesions (Zhang et al., 2002). Additional proteins that interact with PINCH-IL...
    • Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
      Osteopontin-mediated events, organism-specific biosystem
      Osteopontin-mediated events
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
      Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686F1765

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell aging IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction assembly TAS
    Traceable Author Statement
    more info
     
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
     
    integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin assembly IEA
    Inferred from Electronic Annotation
    more info
     
    myelination in peripheral nervous system IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    nerve development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet aggregation HMP PubMed 
    positive regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IDA
    Inferred from Direct Assay
    more info
     
    cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    costamere IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion HDA PubMed 
    focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    sarcomere IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    integrin-linked protein kinase
    Names
    59 kDa serine/threonine-protein kinase
    epididymis secretory protein Li 28
    integrin-linked kinase-2
    NP_001014794.1
    NP_001014795.1
    NP_001265370.1
    NP_001265371.1
    NP_004508.1
    XP_005252961.1
    XP_005252962.1
    XP_011518367.1
    XP_016873161.1
    XP_024304262.1
    XP_024304263.1
    XP_024304264.1
    XP_024304265.1
    XP_024304266.1
    XP_024304267.1
    XP_024304268.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029702.1 RefSeqGene

      Range
      4975..12142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_444

    mRNA and Protein(s)

    1. NM_001014794.2NP_001014794.1  integrin-linked protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001014794.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      BC001554, DC380243, HY257434, U40282
      Consensus CDS
      CCDS7768.1
      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Related
      ENSP00000403487.2, ENST00000420936.6
      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    2. NM_001014795.2NP_001014795.1  integrin-linked protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001014795.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      CR749220, DC379936, HY257434, U40282
      Consensus CDS
      CCDS7768.1
      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Related
      ENSP00000379975.2, ENST00000396751.6
      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    3. NM_001278441.1NP_001265370.1  integrin-linked protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001265370.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons in the coding region, which results in a section that contains a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC091564, AK296628, DC380243, HY257434, U40282
      Consensus CDS
      CCDS60712.1
      UniProtKB/Swiss-Prot
      Q13418
      Related
      ENSP00000435323.1, ENST00000528995.5
      Conserved Domains (3) summary
      cd00204
      Location:28117
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:144388
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    4. NM_001278442.1NP_001265371.1  integrin-linked protein kinase isoform 3

      See identical proteins and their annotated locations for NP_001265371.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks an exon in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK293474, DC380243, HY257434
      Consensus CDS
      CCDS60713.1
      UniProtKB/Swiss-Prot
      Q13418
      Related
      ENSP00000434492.2, ENST00000532063.5
      Conserved Domains (1) summary
      cd14057
      Location:63315
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    5. NM_004517.3NP_004508.1  integrin-linked protein kinase isoform 1

      See identical proteins and their annotated locations for NP_004508.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      DC380243, HY257434, U40282
      Consensus CDS
      CCDS7768.1
      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Related
      ENSP00000299421.3, ENST00000299421.8
      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      6603708..6610874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448499.1XP_024304267.1  integrin-linked protein kinase isoform X3

    2. XM_017017672.1XP_016873161.1  integrin-linked protein kinase isoform X3

      Conserved Domains (3) summary
      cd00204
      Location:289
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:146398
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:1546
      ANK; ANK repeat [structural motif]
    3. XM_005252904.5XP_005252961.1  integrin-linked protein kinase isoform X2

      See identical proteins and their annotated locations for XP_005252961.1

      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    4. XM_024448495.1XP_024304263.1  integrin-linked protein kinase isoform X1

      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:228480
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    5. XM_024448494.1XP_024304262.1  integrin-linked protein kinase isoform X1

      Related
      ENSP00000439606.2, ENST00000537806.5
      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:228480
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    6. XM_024448498.1XP_024304266.1  integrin-linked protein kinase isoform X3

    7. XM_024448500.1XP_024304268.1  integrin-linked protein kinase isoform X4

      Conserved Domains (1) summary
      cd14057
      Location:94346
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    8. XM_005252905.3XP_005252962.1  integrin-linked protein kinase isoform X5

      See identical proteins and their annotated locations for XP_005252962.1

      UniProtKB/Swiss-Prot
      Q13418
      Conserved Domains (1) summary
      cd14057
      Location:63315
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    9. XM_024448496.1XP_024304264.1  integrin-linked protein kinase isoform X1

      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:228480
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    10. XM_011520065.1XP_011518367.1  integrin-linked protein kinase isoform X2

      See identical proteins and their annotated locations for XP_011518367.1

      UniProtKB/Swiss-Prot
      Q13418
      UniProtKB/TrEMBL
      V9HWF0
      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:197449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
    11. XM_024448497.1XP_024304265.1  integrin-linked protein kinase isoform X1

      Conserved Domains (3) summary
      cd00204
      Location:28140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:228480
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:3364
      ANK; ANK repeat [structural motif]
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