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    IL13RA2 interleukin 13 receptor subunit alpha 2 [ Homo sapiens (human) ]

    Gene ID: 3598, updated on 7-Oct-2018

    Summary

    Official Symbol
    IL13RA2provided by HGNC
    Official Full Name
    interleukin 13 receptor subunit alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:5975
    See related
    Ensembl:ENSG00000123496 MIM:300130; Vega:OTTHUMG00000022229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT19; IL-13R; IL13BP; CD213A2
    Summary
    The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 16.6), appendix (RPKM 2.7) and 6 other tissues See more
    Orthologs

    Genomic context

    See IL13RA2 in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (115003975..115017644, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (114238538..114252207, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 2C Neighboring gene uncharacterized LOC105373313 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 7 Neighboring gene microRNA 448 Neighboring gene RNA, U6 small nuclear 648, pseudogene Neighboring gene zinc finger protein 670 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-13 receptor subunit alpha-2
    Names
    IL-13 receptor subunit alpha-2
    IL-13R subunit alpha-2
    IL-13R-alpha-2
    IL-13RA2
    cancer/testis antigen 19
    interleukin 13 binding protein
    interleukin 13 receptor alpha 2 chain
    interleukin 13 receptor, alpha 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012514.1 RefSeqGene

      Range
      5001..18670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000640.2NP_000631.1  interleukin-13 receptor subunit alpha-2 precursor

      See identical proteins and their annotated locations for NP_000631.1

      Status: REVIEWED

      Source sequence(s)
      Y08768
      Consensus CDS
      CCDS14565.1
      UniProtKB/Swiss-Prot
      Q14627
      Related
      ENSP00000243213.1, ENST00000243213.1
      Conserved Domains (1) summary
      pfam09240
      Location:142235
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      115003975..115017644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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