Format

Send to:

Choose Destination
    • Showing Current items.

    IL13RA2 interleukin 13 receptor subunit alpha 2 [ Homo sapiens (human) ]

    Gene ID: 3598, updated on 16-Aug-2021

    Summary

    Official Symbol
    IL13RA2provided by HGNC
    Official Full Name
    interleukin 13 receptor subunit alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:5975
    See related
    Ensembl:ENSG00000123496 MIM:300130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT19; IL-13R; IL13BP; CD213A2
    Summary
    The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 16.6), appendix (RPKM 2.7) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL13RA2 in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (115003982..115017616, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (114238545..114252179, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 2C Neighboring gene uncharacterized LOC105373313 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 7 Neighboring gene microRNA 448 Neighboring gene RNA, U6 small nuclear 648, pseudogene Neighboring gene zinc finger protein 670 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-13 receptor subunit alpha-2
    Names
    IL-13 receptor subunit alpha-2
    IL-13R subunit alpha-2
    IL-13R-alpha-2
    IL-13RA2
    cancer/testis antigen 19
    interleukin 13 binding protein
    interleukin 13 receptor alpha 2 chain
    interleukin 13 receptor, alpha 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012514.1 RefSeqGene

      Range
      5029..18663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000640.3NP_000631.1  interleukin-13 receptor subunit alpha-2 precursor

      See identical proteins and their annotated locations for NP_000631.1

      Status: REVIEWED

      Source sequence(s)
      Y08768
      Consensus CDS
      CCDS14565.1
      UniProtKB/Swiss-Prot
      Q14627
      Related
      ENSP00000243213.1, ENST00000243213.2
      Conserved Domains (1) summary
      pfam09240
      Location:142235
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      115003982..115017616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center