Format

Send to:

Choose Destination
    • Showing Current items.

    IL13RA1 interleukin 13 receptor subunit alpha 1 [ Homo sapiens (human) ]

    Gene ID: 3597, updated on 8-Jul-2021

    Summary

    Official Symbol
    IL13RA1provided by HGNC
    Official Full Name
    interleukin 13 receptor subunit alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:5974
    See related
    Ensembl:ENSG00000131724 MIM:300119
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NR4; CT19; CD213A1; IL-13Ra
    Summary
    The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in colon (RPKM 22.2), liver (RPKM 22.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL13RA1 in Genome Data Viewer
    Location:
    Xq24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (118726954..118794533)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (117861569..117928496)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene WD repeat domain 44 Neighboring gene microRNA 1277 Neighboring gene dedicator of cytokinesis 11 Neighboring gene RBBP8 pseudogene 1 Neighboring gene TMEM30B pseudogene 1 Neighboring gene zinc finger CCHC-type containing 12 Neighboring gene long intergenic non-protein coding RNA 1285 Neighboring gene AKR7A2P pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of interleukin 13 receptor, alpha 1 gene (IL13RA1) in mammary epithelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ciliary neurotrophic factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables leukemia inhibitory factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to oncostatin-M receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in leukemia inhibitory factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oncostatin-M-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of interleukin-13 receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-13 receptor subunit alpha-1
    Names
    CD213a1 antigen
    IL-13 receptor subunit alpha-1
    IL-13R subunit alpha-1
    IL13 receptor alpha-1 chain
    cancer/testis antigen 19
    interleukin 13 receptor, alpha 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012841.1 RefSeqGene

      Range
      5011..71938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001560.3NP_001551.1  interleukin-13 receptor subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_001551.1

      Status: REVIEWED

      Source sequence(s)
      AL391280
      Consensus CDS
      CCDS14573.1
      UniProtKB/Swiss-Prot
      P78552
      Related
      ENSP00000360730.3, ENST00000371666.8
      Conserved Domains (2) summary
      cd00063
      Location:228336
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:131224
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      118726954..118794533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531336.1XP_011529638.1  interleukin-13 receptor subunit alpha-1 isoform X1

      Conserved Domains (2) summary
      cd00063
      Location:330438
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09240
      Location:231326
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    2. XM_017029507.1XP_016884996.1  interleukin-13 receptor subunit alpha-1 isoform X2

    Support Center