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    IL10RB interleukin 10 receptor subunit beta [ Homo sapiens (human) ]

    Gene ID: 3588, updated on 12-Aug-2018

    Summary

    Official Symbol
    IL10RBprovided by HGNC
    Official Full Name
    interleukin 10 receptor subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:5965
    See related
    Ensembl:ENSG00000243646 MIM:123889; Vega:OTTHUMG00000065128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2
    Summary
    The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See IL10RB in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (33266360..33297234)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34638665..34669539)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene IL10RB divergent transcript Neighboring gene interferon alpha and beta receptor subunit 1 Neighboring gene upstream transcription factor 1 pseudogene 1 Neighboring gene interferon gamma receptor 2 Neighboring gene transmembrane protein 50B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hepatitis b virus, susceptibility to
    MedGen: C1864880 OMIM: 610424 GeneReviews: Not available
    Compare labs
    Inflammatory bowel disease 25, autosomal recessive
    MedGen: C2675508 OMIM: 612567 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-10 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-10 signaling, organism-specific biosystemInterleukin-10 (IL10) was originally described as a factor named cytokine synthesis inhibitory factor that inhibited T-helper (Th) 1 activation and Th1 cytokine production (Fiorentino et al. 1989). ...
    • Interleukin-19, 20, 22, 24, organism-specific biosystem (from REACTOME)
      Interleukin-19, 20, 22, 24, organism-specific biosystemThe interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type III interferon signaling, organism-specific biosystem (from WikiPathways)
      Type III interferon signaling, organism-specific biosystemThe recently identified type III interferon group consists of three IFN-? (lambda) genes encoding molecules called IFN-?1, IFN-?2 and IFN-?3 (also called IL29, IL28A and IL28B respectively). These IF...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: IFNAR2

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to interleukin-10 receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-28 receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-10 receptor subunit beta
    Names
    IL-10 receptor subunit beta
    IL-10R subunit 2
    IL-10R subunit beta
    IL-10RB
    cytokine receptor class-II CRF2-4
    cytokine receptor class-II member 4
    cytokine receptor family 2 member 4
    cytokine receptor family II, member 4
    interleukin 10 receptor, beta
    interleukin-10 receptor subunit 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012089.1 RefSeqGene

      Range
      4994..35868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_152

    mRNA and Protein(s)

    1. NM_000628.4NP_000619.3  interleukin-10 receptor subunit beta precursor

      See identical proteins and their annotated locations for NP_000619.3

      Status: REVIEWED

      Source sequence(s)
      AI025402, AU133530, BC001903, Z17227
      Consensus CDS
      CCDS13623.1
      UniProtKB/Swiss-Prot
      Q08334
      Related
      ENSP00000290200.2, OTTHUMP00000067678, ENST00000290200.6, OTTHUMT00000139831
      Conserved Domains (2) summary
      pfam09294
      Location:111213
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:21100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

      Range
      33266360..33297234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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