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    IL10RB interleukin 10 receptor subunit beta [ Homo sapiens (human) ]

    Gene ID: 3588, updated on 25-Nov-2021

    Summary

    Official Symbol
    IL10RBprovided by HGNC
    Official Full Name
    interleukin 10 receptor subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:5965
    See related
    Ensembl:ENSG00000243646 MIM:123889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2
    Summary
    The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See IL10RB in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (33266367..33297221)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34638672..34669526)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372787 Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene IL10RB divergent transcript Neighboring gene IFNAR1 promoter region Neighboring gene interferon alpha and beta receptor subunit 1 Neighboring gene upstream transcription factor 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
    GeneReviews: Not available
    Hepatitis b virus, susceptibility to
    MedGen: C1864880 OMIM: 610424 GeneReviews: Not available
    Compare labs
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Inflammatory bowel disease 25, autosomal recessive
    MedGen: C2675508 OMIM: 612567 GeneReviews: Not available
    Compare labs

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: IFNAR2

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to interleukin-10 receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of interleukin-28 receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-10 receptor subunit beta
    Names
    IL-10 receptor subunit beta
    IL-10R subunit 2
    IL-10R subunit beta
    IL-10RB
    cytokine receptor class-II CRF2-4
    cytokine receptor class-II member 4
    cytokine receptor family 2 member 4
    cytokine receptor family II, member 4
    interleukin 10 receptor, beta
    interleukin-10 receptor subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012089.1 RefSeqGene

      Range
      4994..35868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_152

    mRNA and Protein(s)

    1. NM_000628.5NP_000619.3  interleukin-10 receptor subunit beta precursor

      See identical proteins and their annotated locations for NP_000619.3

      Status: REVIEWED

      Source sequence(s)
      AI025402, AU133530, BC001903, Z17227
      Consensus CDS
      CCDS13623.1
      UniProtKB/Swiss-Prot
      Q08334
      Related
      ENSP00000290200.2, ENST00000290200.7
      Conserved Domains (2) summary
      pfam09294
      Location:111213
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:21100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

      Range
      33266367..33297221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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