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    IL10 interleukin 10 [ Homo sapiens (human) ]

    Gene ID: 3586, updated on 9-Oct-2021

    Summary

    Official Symbol
    IL10provided by HGNC
    Official Full Name
    interleukin 10provided by HGNC
    Primary source
    HGNC:HGNC:5962
    See related
    Ensembl:ENSG00000136634 MIM:124092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSIF; TGIF; GVHDS; IL-10; IL10A
    Summary
    The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
    Expression
    Broad expression in appendix (RPKM 3.8), lymph node (RPKM 2.5) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL10 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (206767602..206772494, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206940947..206945839, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MAPK activated protein kinase 2 Neighboring gene ribosomal protein S14 pseudogene 1 Neighboring gene uncharacterized LOC105372877 Neighboring gene interleukin 19 Neighboring gene uncharacterized LOC105372878 Neighboring gene interleukin 20

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
    GeneReviews: Not available
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
    GeneReviews: Not available
    Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.
    GeneReviews: Not available
    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
    GeneReviews: Not available
    Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
    GeneReviews: Not available
    Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.
    GeneReviews: Not available
    Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
    GeneReviews: Not available
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    GeneReviews: Not available
    Graft-versus-host disease, susceptibility to
    MedGen: C3280677 OMIM: 614395 GeneReviews: Not available
    Compare labs
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Human immunodeficiency virus type 1, susceptibility to
    MedGen: C1836230 OMIM: 609423 GeneReviews: Not available
    Compare labs
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    GeneReviews: Not available
    Rheumatoid arthritis
    MedGen: C0003873 OMIM: 180300 GeneReviews: Not available
    Compare labs
    Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Clinical samples of cerebrospinal fluid from patients infected with HIV-1 subtypes B and C exhibited upregulated levels of IL7, IL10, CXCL10 (IP10), CCL2 (MCP1), and CCL3 (MIP1A) PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 IIIB Env (gp120) upregulates production of TNF (TNF-a), IL-17A, CCL2 (MCP1), CCL5 (RANTES), IL6, IL10, CXCL8 (IL8), CXCL1 (GRO-a), and CCL1 (I309) in stimulated monocyte derived macrophages PubMed
    env Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta PubMed
    env HIV-1 gp120 upregulates the expression of interleukin 10 (IL-10) in human B cells PubMed
    env HIV-1 gp120-expanded CD33+ myeloid derived suppressor cells increase IL-10 production and CD4+/CD25+/FoxP3+ regulatory T-cell levels in T-cell cocultures PubMed
    env HIV-1 gp120-induced release of IL-10 depends on the activation of Raf-1 along with NF-kappaB p65 in immature dentritic cells PubMed
    env HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and IL-6 dependent STAT3 in immature dentritic cells PubMed
    env HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
    env HIV-1 gp120 induces the release of cytokines MIP-1 alpha, MIP-1 beta, IL-6, IL-10, and TNF-alpha in immature dentritic cells PubMed
    env HIV-1 gp120 induces IL-10 expression in monocyte-derived dendritic cells via a mannose C-type lectin receptor and ERK signaling pathway PubMed
    env HIV-1 gp120 cooperates with BAFF and cytokines IL-4 and IL-10 to activate mannose C-type lectin receptors-expressing B cells PubMed
    env HIV-1 gp120-induced reduction of IL-12 parallels IL-10 induction and inhibits translocation of CD40 to the surface of monocytes PubMed
    Envelope surface glycoprotein gp160, precursor env IL-10-producing B cells in HIV-1 infection are enriched for HIV-1 trimeric Env specificity PubMed
    env HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
    env Chimeric HIV-1 gp140 - CD40L trimers can target and activate dendritic cells to release IL-6, IL-10 and IL-12 PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IL-10 in peptide-treated PBMCs PubMed
    env HIV-1 gp41 induces IL-10 expression in human monocytes and gp41-induced IL-10 expression leads to reduced IL-2 and interferon-gamma production PubMed
    env Mutations L576A, Q577A, A578G, R579A, E584A, and D589A in the conserved immunosuppressive domain (amino acids 576-589) of HIV-1 gp41 significantly downregulate IL-10 release from human PBMCs PubMed
    env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
    env IL-10 inhibits gp41-induced IL-6 production and reduces the expression of IL-6 mRNA PubMed
    Nef nef HIV-1 Nef induces the release of cytokines MIP-1 alpha, MIP-1 beta, IL-6, IL-10, and TNF-alpha in immature dentritic cells PubMed
    nef HIV-1 Nef significantly upregulates IL-10 protein and mRNA expression in monocytes but not in T or B lymphocytes; by contrast, SEA induced IL-10 protein and mRNA expression in T lymphocytes but not in monocytes or B lymphocytes PubMed
    nef HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
    nef HIV-1 Nef inhibits IFN-gamma-induced apoptosis and upregulates TNF-alpha, IL-6 and MIP-3alpha production by Caco-2 cells while downregulating IL-10 production PubMed
    nef HIV-1 Nef suppresses immunoglobulin class-switch DNA recombination by inducing IkappaBalpha and SOCS proteins, which block CD154, IL-4 and IL-10 cytokine signaling via NF-kappaB and STAT transcription factors PubMed
    nef Herbimycin A significantly blocks HIV-1 Nef-induced production of IL-10 at both the protein and the mRNA level, demonstrating the involvement of a herbimycin A-sensitive Protein tyrosine kinase in the signal transduction pathway for exogenous HIV-1 Nef PubMed
    nef Extracellular HIV-1 Nef induces interleukin (IL)-10 mRNA expression in human PBMCs as well as in H9 T and U937 promonocytic human cell lines; release of IL-10 into supernatants from PBMCs stimulated with Nef is dose-dependent PubMed
    Pol gag-pol HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
    Pr55(Gag) gag Expression of IL-10 is significantly upregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs PubMed
    gag IL-10 production in response to HIV-1 gag stimulation is observed in a subset of CD8(+) T cells with a CD25(-)/ FoxP3(-) phenotype PubMed
    gag HIV-1 Gag virus-like particles expressed by recombinant baculoviruses activate human PBMC to release IL-10 in a dose and time dependent manner PubMed
    gag Immunosuppressive peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag upregulate prostaglandin E2 production and induce IL-10 secretion PubMed
    Tat tat HIV-1 Tat activates TLR4, which induces production of TNF and IL10 in human monocytes PubMed
    tat HIV-1 Tat upregulates expression of IL-10 in peripheral blood monocytes, macrophages, and T-cell lines through a protein kinase C dependent mechanism involving NF-kappa B, ERK1, and ERK2 PubMed
    tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta PubMed
    tat HIV-1 Tat-induced release of TNF-alpha and IL-10 is TLR4-dependent in monocytes PubMed
    tat HIV-1 Tat induces production of IL-10 through the activation of PKC beta(II) and delta isozymes in human monocytes and macrophages PubMed
    tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
    tat Calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK play a role in extracellular Tat-induced IL-10 expression in primary human monocytes PubMed
    tat Ets1- and Sp1-binding sites as specific inducible responsive elements are required for HIV-1 Tat-induced IL-10 promoter activation; Ets-1 is essential for the Tat-induced activation of IL-10 PubMed
    tat Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) PubMed
    tat Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 PubMed
    tat Monocytes treated with HIV-1 clade C Tat show significant upregulation of anti-inflammatory cytokines, IL-4 and IL-10, as compared to clade B Tat-treated cultures PubMed
    tat The cysteine to serine mutation at position 31 in HIV-1 clade C Tat results in a marked decrease in IL-10 production in monocytes compared with clade B Tat. p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production PubMed
    tat IL10 and STAT3 are required for HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells PubMed
    tat IL-10 inhibits HIV-1 gene expression in an HIV-1 Tat-dependent manner by downregulating cyclin T1 expression through the induction of proteasome-mediated proteolysis in human macrophages PubMed
    Vif vif HIV-1 Vif upregulates the expression of interleukin 10 (IL10) in Vif-expression T cells PubMed
    Vpr vpr HIV-1 Vpr upregulates the production of interleukin 10 (IL-10) in dendritic cells PubMed
    vpr HIV-1 Vpr modulates expression of interleukin 10 (IL-10), increasing or suppressing IL-10 expression through varying effects on NF-kappa B activity in different cell lines PubMed
    capsid gag Immunosuppressive peptides corresponding to HIV-1 Capsid amino acids 218-238 upregulate prostaglandin E2 production and induce IL-10 secretion PubMed
    reverse transcriptase gag-pol IL-10 inhibits HIV-1 replication in primary tissue culture-derived macrophages in a dose-dependent manner, decreases HIV-1 reverse transcription upon macrophage infection, and subsequently mediates viral latency in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126450, MGC126451

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables growth factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables interleukin-10 receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in B cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in labyrinthine layer morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hepatocyte growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cytoplasmic sequestering of NF-kappaB NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to protozoan IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hemopoiesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in leukocyte chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in liver regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of MHC class II biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of MHC class II biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of T cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of chronic inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cytokine activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cytokine production involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of heterotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of hydrogen peroxide-induced neuron death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of interferon-alpha production NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-1 production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of interleukin-12 production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of interleukin-18 production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of interleukin-8 production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of myeloid dendritic cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of B cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MHC class II biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of heterotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of positive regulation of immunoglobulin production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of plasma cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in regulation of complement-dependent cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of isotype switching NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of response to wounding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to carbon monoxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucocorticoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to inactivity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type 2 immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-10
    Names
    T-cell growth inhibitory factor
    cytokine synthesis inhibitory factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012088.1 RefSeqGene

      Range
      5001..9893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1230

    mRNA and Protein(s)

    1. NM_000572.3NP_000563.1  interleukin-10 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000563.1

      Status: REVIEWED

      Source sequence(s)
      BC022315, CD369014, M57627
      Consensus CDS
      CCDS1467.1
      UniProtKB/Swiss-Prot
      P22301
      UniProtKB/TrEMBL
      Q6FGW4
      Related
      ENSP00000412237.1, ENST00000423557.1
      Conserved Domains (1) summary
      pfam00726
      Location:5174
      IL10; Interleukin 10
    2. NM_001382624.1NP_001369553.1  interleukin-10 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL513315
      Conserved Domains (1) summary
      cl02501
      Location:189
      IL10; Interleukin 10

    RNA

    1. NR_168466.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL513315
    2. NR_168467.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL513315
      Related
      ENST00000640756.1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      206767602..206772494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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