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    CXCR1 C-X-C motif chemokine receptor 1 [ Homo sapiens (human) ]

    Gene ID: 3577, updated on 5-Aug-2022

    Summary

    Official Symbol
    CXCR1provided by HGNC
    Official Full Name
    C-X-C motif chemokine receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:6026
    See related
    Ensembl:ENSG00000163464 MIM:146929; AllianceGenome:HGNC:6026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
    Summary
    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in appendix (RPKM 17.0), spleen (RPKM 9.7) and 6 other tissues See more
    Orthologs
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    Genomic context

    See CXCR1 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218162841..218166962, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218648531..218652652, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219027564..219031685, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RUN and FYVE domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 3825 Neighboring gene C-X-C motif chemokine receptor 2 Neighboring gene small nucleolar RNA U13 Neighboring gene high mobility group box 1 pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Susceptibility to HIV infection
    MedGen: C1836230 OMIM: 609423 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Progressive HIV-1 infection is linked to upregulated CXCL8 (IL8), CXCR1, and PTPN11 (SHP2) expression in PBMC samples from HIV-1 infected children PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef induces variable levels of CXCR1 downregulation in different cell types PubMed
    capsid gag CXCL8-induced upregulation of HIV-1 p24 levels and 2-LTR cycles is inhibited by CXCR1 or CXCR2 neutralization in HIV-1-infected monocytes-derived macrophages PubMed
    matrix gag CXCR1-expressing Jurkat cells can migrate in response to HIV-1 MA, but cannot activate ERK1/2 signaling pathway and intracellular calcium mobilization PubMed
    gag Surface plasmon resonance (SPR) binding assay demonstrates that HIV-1 MA and SIV MA bind CXCR1 with similar affinities PubMed
    gag The N-terminal basic motif (residues 25-34) of HIV-1 MA is required for its binding to CXCR1, while heparin and heparin sulfate also bind to the basic motif PubMed
    gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed
    gag HIV-1 p17-induced monocyte migratory activity is regulated by the p17/CRCX1 interaction PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables interleukin-8 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables interleukin-8 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendritic cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in interleukin-8-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-X-C chemokine receptor type 1
    Names
    CXC-R1
    CXCR-1
    IL-8 receptor type 1
    IL-8R A
    chemokine (C-X-C motif) receptor 1
    high affinity interleukin-8 receptor A
    interleukin 8 receptor, alpha
    interleukin-8 receptor type 1
    interleukin-8 receptor type A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011814.1 RefSeqGene

      Range
      5032..9153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000634.3NP_000625.1  C-X-C chemokine receptor type 1

      See identical proteins and their annotated locations for NP_000625.1

      Status: REVIEWED

      Source sequence(s)
      AC097483
      Consensus CDS
      CCDS2409.1
      UniProtKB/Swiss-Prot
      P25024, Q9P2U2
      Related
      ENSP00000295683.2, ENST00000295683.3
      Conserved Domains (1) summary
      pfam00001
      Location:56305
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      218162841..218166962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      218648531..218652652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)