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    IGLC1 immunoglobulin lambda constant 1 [ Homo sapiens (human) ]

    Gene ID: 3537, updated on 18-Aug-2020

    Summary

    Official Symbol
    IGLC1provided by HGNC
    Official Full Name
    immunoglobulin lambda constant 1provided by HGNC
    Primary source
    HGNC:HGNC:5855
    See related
    Ensembl:ENSG00000211675 IMGT/GENE-DB:IGLC1; MIM:147220
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGLC

    Genomic context

    See IGLC1 in Genome Data Viewer
    Location:
    22q11.22
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (22895375..22895694)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (23237555..23237874)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene microRNA 5571 Neighboring gene immunoglobulin lambda like polypeptide 5 Neighboring gene immunoglobulin lambda joining 1 Neighboring gene immunoglobulin lambda joining 2 Neighboring gene immunoglobulin lambda constant 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • C1 segment
    • immunoglobulin lambda constant 1 (Mcg marker)
    • immunoglobulin lambda constant region 1 (Mcg marker)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    antigen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    complement activation TAS
    Traceable Author Statement
    more info
     
    complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    complement activation, classical pathway TAS
    Traceable Author Statement
    more info
     
    defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagocytosis, recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    regulation of complement activation TAS
    Traceable Author Statement
    more info
     
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    blood microparticle HDA PubMed 
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space HDA PubMed 
    immunoglobulin complex, circulating IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_000002.1 

      Range
      861539..861858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      22895375..22895694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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