IGLC1 immunoglobulin lambda constant 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IGLC1provided by HGNC
Official Full Name: immunoglobulin lambda constant 1provided by HGNC
Primary source: HGNC:HGNC:5855
See related: Ensembl:ENSG00000211675 IMGT/GENE-DB:IGLC1; MIM:147220; AllianceGenome:HGNC:5855
Gene type: other
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IGLC
Summary: Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

Location:: 22q11.22

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (22895375..22895694)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (23318284..23318603)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (23237555..23237874)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The human Iglambda locus is isolated intact as an ~300-kilobase yeast artificial chromosome (YAC) and also fully inserted into a rat chromosome.
Title: High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.
New sequencing data show that the Mcg-Ke+Oz- isotype is encoded by a polymorphic C lambda 2 gene segment that differs from the normal J-C lambda 2 region at a single nucleotide position.
Title: Unraveling of the polymorphic C lambda 2-C lambda 3 amplification and the Ke+Oz- polymorphism in the human Ig lambda locus.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D22S1243 (e-PCR)
- UniSTS:54812

RH71387 (e-PCR)
- UniSTS:15712

D22S1543 (e-PCR)
- UniSTS:62567

RH71381 (e-PCR)
- UniSTS:13673

G54039 (e-PCR)
- UniSTS:109421

IGLC6 (e-PCR)
- UniSTS:266610

STS-X51755 (e-PCR)
- UniSTS:16533

RH71286 (e-PCR)
- UniSTS:12708

RH71287 (e-PCR)
- UniSTS:12709

D22S1040 (e-PCR)
- UniSTS:38058

GDB:452623 (e-PCR)
- UniSTS:157397

Other Names

C1 segment
immunoglobulin lambda constant 1 (Mcg marker)
immunoglobulin lambda constant region 1 (Mcg marker)

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables antigen binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in adaptive immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of IgA immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
part_of IgD immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
part_of IgE immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
part_of IgG immunoglobulin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IgG immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
part_of IgM immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
located_in blood microparticle	HDA more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	NAS Non-traceable Author Statement more info	PubMed
part_of immunoglobulin complex	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.