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    IGKC immunoglobulin kappa constant [ Homo sapiens (human) ]

    Gene ID: 3514, updated on 8-Jul-2021

    Summary

    Official Symbol
    IGKCprovided by HGNC
    Official Full Name
    immunoglobulin kappa constantprovided by HGNC
    Primary source
    HGNC:HGNC:5716
    See related
    Ensembl:ENSG00000211592 IMGT/GENE-DB:IGKC; MIM:147200
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Km; HCAK1; IGKCD
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

    See IGKC in Genome Data Viewer
    Location:
    2p11.2
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (88857361..88857683, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (89156874..89157196, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374854 Neighboring gene MIR4436A-IGK intergenic CAGE-defined B cell enhancer Neighboring gene immunoglobulin kappa deleting element or like Neighboring gene immunoglobulin kappa joining 5 Neighboring gene immunoglobulin kappa joining 4 Neighboring gene immunoglobulin kappa locus

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • immunoglobulin kappa (invariant region)
    • immunoglobulin kappa constant region
    • immunoglobulin kappa light chain (VJ)

    Clone Names

    • MGC62011, MGC72072, MGC88770, MGC88771, MGC88809, MGC111575

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables antigen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in immunoglobulin production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phagocytosis, recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in retina homeostasis HEP PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_000834.1 

      Range
      484017..484339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      88857361..88857683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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