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    IGKC immunoglobulin kappa constant [ Homo sapiens (human) ]

    Gene ID: 3514, updated on 12-Aug-2018

    Summary

    Official Symbol
    IGKCprovided by HGNC
    Official Full Name
    immunoglobulin kappa constantprovided by HGNC
    Primary source
    HGNC:HGNC:5716
    See related
    IMGT/GENE-DB:IGKC; MIM:147200
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Km; HCAK1; IGKCD
    Annotation information
    Annotation category: partial on reference assembly

    Genomic context

    See IGKC in Genome Data Viewer
    Location:
    2p11.2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (88857361..88857683, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (89156874..89157196, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374854 Neighboring gene MIR4436A-IGK intergenic CAGE-defined B cell enhancer Neighboring gene immunoglobulin kappa deleting element or like Neighboring gene immunoglobulin kappa joining 5 Neighboring gene immunoglobulin kappa joining 4 Neighboring gene immunoglobulin kappa locus

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • immunoglobulin kappa (invariant region)
    • immunoglobulin kappa constant region
    • immunoglobulin kappa light chain (VJ)

    Clone Names

    • MGC62011, MGC72072, MGC88770, MGC88771, MGC88809, MGC111575

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    antigen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    complement activation TAS
    Traceable Author Statement
    more info
     
    complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    complement activation, classical pathway TAS
    Traceable Author Statement
    more info
     
    defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    immunoglobulin production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagocytosis, recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
     
    regulation of complement activation TAS
    Traceable Author Statement
    more info
     
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    retina homeostasis HEP PubMed 
    Component Evidence Code Pubs
    blood microparticle HDA PubMed 
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space HDA PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immunoglobulin complex, circulating IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_000834.1 

      Range
      484017..484339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      88857361..88857683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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