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    APOD apolipoprotein D [ Homo sapiens (human) ]

    Gene ID: 347, updated on 26-Aug-2018

    Summary

    Official Symbol
    APODprovided by HGNC
    Official Full Name
    apolipoprotein Dprovided by HGNC
    Primary source
    HGNC:HGNC:612
    See related
    Ensembl:ENSG00000189058 MIM:107740; Vega:OTTHUMG00000155854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]
    Expression
    Broad expression in fat (RPKM 368.7), brain (RPKM 153.2) and 16 other tissues See more
    Orthologs

    Genomic context

    See APOD in Genome Data Viewer
    Location:
    3q29
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (195568702..195584205, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195295573..195311076, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 73, pseudogene Neighboring gene ribosomal protein L24 pseudogene 6 Neighboring gene mucin 20, cell surface associated pseudogene 1 Neighboring gene uncharacterized LOC107986029

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cholesterol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    aging NAS
    Non-traceable Author Statement
    more info
    PubMed 
    angiogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cytokine production involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lipoprotein lipid oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of monocyte chemotactic protein-1 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peripheral nervous system axon regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to axon injury ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to drug ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to reactive oxygen species IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tissue regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytosolic ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region HDA PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular space HDA PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    apolipoprotein D
    Names
    apo-D

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001647.3NP_001638.1  apolipoprotein D precursor

      See identical proteins and their annotated locations for NP_001638.1

      Status: REVIEWED

      Source sequence(s)
      AC069213, BC007402, BU727194, DA892855
      Consensus CDS
      CCDS33925.1
      UniProtKB/Swiss-Prot
      P05090
      Related
      ENSP00000345179.3, OTTHUMP00000208785, ENST00000343267.7, OTTHUMT00000342004
      Conserved Domains (1) summary
      cl21528
      Location:37182
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      195568702..195584205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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