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    CD300E CD300e molecule [ Homo sapiens (human) ]

    Gene ID: 342510, updated on 5-Mar-2024

    Summary

    Official Symbol
    CD300Eprovided by HGNC
    Official Full Name
    CD300e moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:28874
    See related
    Ensembl:ENSG00000186407 MIM:609801; AllianceGenome:HGNC:28874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLM2; CLM-2; IREM2; PIgR2; IREM-2; PIgR-2; CD300LE; CMRF35-A5
    Summary
    This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
    Expression
    Biased expression in appendix (RPKM 19.2), bone marrow (RPKM 15.3) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CD300E in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74609885..74623738, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75500469..75514322, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72606024..72619877, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72564995-72565725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72565726-72566455 Neighboring gene CD300H molecule (gene/pseudogene) Neighboring gene CD300LD antisense RNA 1 Neighboring gene CD300 molecule like family member d Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12713 Neighboring gene uncharacterized LOC101928343 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:72627822-72628322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:72628323-72628823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12714 Neighboring gene uncharacterized LOC105371894 Neighboring gene RAB37, member RAS oncogene family Neighboring gene CD300 molecule like family member f

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    CMRF35-like molecule 2
    Names
    CD300 antigen-like family member E
    CD300e antigen
    immune receptor expressed on myeloid cells 2
    poly-Ig receptor 2
    polymeric immunoglobulin receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181449.3NP_852114.2  CMRF35-like molecule 2 precursor

      See identical proteins and their annotated locations for NP_852114.2

      Status: VALIDATED

      Source sequence(s)
      AC064805, AK303545, BC100890
      Consensus CDS
      CCDS11702.1
      UniProtKB/Swiss-Prot
      B4DNS1, Q496F6, Q7Z7I3
      UniProtKB/TrEMBL
      B4E0V9
      Related
      ENSP00000376395.2, ENST00000392619.2
      Conserved Domains (2) summary
      cd05716
      Location:24104
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:21104
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      74609885..74623738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      75500469..75514322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)