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    ID2 inhibitor of DNA binding 2 [ Homo sapiens (human) ]

    Gene ID: 3398, updated on 17-Mar-2024

    Summary

    Official Symbol
    ID2provided by HGNC
    Official Full Name
    inhibitor of DNA binding 2provided by HGNC
    Primary source
    HGNC:HGNC:5361
    See related
    Ensembl:ENSG00000115738 MIM:600386; AllianceGenome:HGNC:5361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GIG8; ID2A; ID2H; bHLHb26
    Summary
    The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in liver (RPKM 128.2), bone marrow (RPKM 111.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    2p25.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (8682056..8684461)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (8705779..8708184)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (8822186..8824591)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373411 Neighboring gene SNRPE pseudogene 5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:8773308-8774507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8777331-8777854 Neighboring gene VISTA enhancer hs1527 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:8802380-8803579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8815873-8816791 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8816792-8817709 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:8818423-8818956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8818957-8819490 Neighboring gene NANOG hESC enhancer GRCh37_chr2:8821385-8821888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8824708-8825498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8825499-8826288 Neighboring gene ID2 antisense RNA 1 Neighboring gene kinase D interacting substrate 220 Neighboring gene ADP ribosylation factor like GTPase 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11130 Neighboring gene Sharpr-MPRA regulatory region 5743 Neighboring gene NANOG hESC enhancer GRCh37_chr2:8995048-8995599 Neighboring gene membrane bound O-acyltransferase domain containing 2 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC26389

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription regulator inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription regulator inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bundle of His development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in embryonic digestive tract morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endodermal digestive tract morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in entrainment of circadian clock by photoperiod ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within enucleate erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial cell differentiation involved in mammary gland alveolus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in locomotor rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mammary gland alveolus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mammary gland epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of neuron fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within olfactory bulb development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of astrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of macrophage differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_negative_effect regulation of neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_negative_effect regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of euchromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    DNA-binding protein inhibitor ID-2
    Names
    DNA-binding protein inhibitor ID2
    cell growth-inhibiting gene 8
    class B basic helix-loop-helix protein 26
    helix-loop-helix protein ID2
    inhibitor of DNA binding 2, HLH protein
    inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
    inhibitor of differentiation 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002166.5NP_002157.2  DNA-binding protein inhibitor ID-2

      See identical proteins and their annotated locations for NP_002157.2

      Status: REVIEWED

      Source sequence(s)
      AC011747
      Consensus CDS
      CCDS1659.1
      UniProtKB/Swiss-Prot
      Q02363
      UniProtKB/TrEMBL
      D6W4Y7, Q53H99, Q53T66
      Related
      ENSP00000379585.1, ENST00000396290.2
      Conserved Domains (1) summary
      cd19692
      Location:1883
      bHLH_dnHLH_ID2; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      8682056..8684461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      8705779..8708184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)