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    TNC tenascin C [ Homo sapiens (human) ]

    Gene ID: 3371, updated on 18-Nov-2018

    Summary

    Official Symbol
    TNCprovided by HGNC
    Official Full Name
    tenascin Cprovided by HGNC
    Primary source
    HGNC:HGNC:5318
    See related
    Ensembl:ENSG00000041982 MIM:187380; Vega:OTTHUMG00000021010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225
    Summary
    This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
    Expression
    Broad expression in appendix (RPKM 76.9), endometrium (RPKM 19.4) and 15 other tissues See more
    Orthologs

    Genomic context

    See TNC in Genome Data Viewer
    Location:
    9q33.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (115019575..115118257, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117781854..117880536, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 4B pseudogene Neighboring gene TNF superfamily member 8 Neighboring gene uncharacterized LOC101928748 Neighboring gene deleted in esophageal cancer 1 Neighboring gene uncharacterized LOC105376233

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Deafness, autosomal dominant 56
    MedGen: C3810170 OMIM: 615629 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 is inhibited by TNC (tenascin C), MUC1, and LTF (lactoferrin) as shown through neutralization assays in TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Preincubation of HIV-1 gp160 and gp120 glycoproteins with soluble CD4 enhances the TNC binding, whereas antibodies against the V3 loop of the Env protein block the TNC binding PubMed
    env Tenascin-C (TNC), an extracellular matrix protein isolated from breast milk, has the HIV-1 neutralization activity by binding to HIV-1 gp160 and gp120 glycoproteins PubMed
    Envelope surface glycoprotein gp160, precursor env Preincubation of HIV-1 gp160 and gp120 glycoproteins with soluble CD4 enhances the TNC binding, whereas antibodies against the V3 loop of the Env protein block the TNC binding PubMed
    env Tenascin-C (TNC), an extracellular matrix protein isolated from breast milk, has the HIV-1 neutralization activity by binding to HIV-1 gp160 and gp120 glycoproteins PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tenascin C (TNC) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, organism-specific biosystem (from WikiPathways)
      Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, organism-specific biosystemThis pathway is based on Figure 4 of "Origins of metastatic traits."(See Bibliography).The majority of cancer cells released from tumors die off, so cancer biologists are trying to figure out exactly...
    • ECM proteoglycans, organism-specific biosystem (from REACTOME)
      ECM proteoglycans, organism-specific biosystemProteoglycans are major components of the extracellular matrix. In cartilage the matrix constitutes more than 90% of tissue dry weight. Proteoglycans are proteins substituted with glycosaminoglycans ...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
      Non-integrin membrane-ECM interactions, organism-specific biosystemSeveral non-integrin membrane proteins interact with extracellular matrix proteins. Transmembrane proteoglycans may associate with integrins and growth factor receptors to influence their function, o...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Syndecan interactions, organism-specific biosystem (from REACTOME)
      Syndecan interactions, organism-specific biosystemSyndecans are type I transmembrane proteins, with an N-terminal ectodomain that contains several consensus sequences for glycosaminoglycan (GAG) attachment and a short C-terminal cytoplasmic domain. ...
    • Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-4-mediated signaling events, organism-specific biosystem
      Syndecan-4-mediated signaling events
    • TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, organism-specific biosystem (from WikiPathways)
      TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, organism-specific biosystemThis pathway is based on the Figure 7 of "Cadherin 6 Is a New RUNX2 Target in TGF-? Signalling Pathway" (see bibliography). TGF-B is a target gene in thyroid cells in the causation of cancer. When TG...
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC167029

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    extracellular matrix structural constituent HDA PubMed 
    extracellular matrix structural constituent ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syndecan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    bud outgrowth involved in lung branching IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    cellular response to prostaglandin D stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to vitamin D IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    mesenchymal-epithelial cell signaling involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation HDA PubMed 
    peripheral nervous system axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    prostate gland epithelium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to fibroblast growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    wound healing IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tenascin
    Names
    GP 150-225
    cytotactin
    deafness, autosomal dominant 56
    glioma-associated-extracellular matrix antigen
    hexabrachion (tenascin)
    myotendinous antigen
    neuronectin
    tenascin-C additional domain 1
    tenascin-C isoform 14/AD1/16

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029637.1 RefSeqGene

      Range
      5001..103683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002160.3NP_002151.2  tenascin precursor

      See identical proteins and their annotated locations for NP_002151.2

      Status: REVIEWED

      Source sequence(s)
      AB210038, AI266750, AI964017, AK304015, BP279008, BU860660, BX100095, X78565
      Consensus CDS
      CCDS6811.1
      UniProtKB/Swiss-Prot
      P24821
      UniProtKB/TrEMBL
      B4E1W8, Q4LE33
      Related
      ENSP00000265131.4, OTTHUMP00000022738, ENST00000350763.8, OTTHUMT00000055418
      Conserved Domains (3) summary
      pfam00147
      Location:19802189
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
      pfam00041
      Location:18881960
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      115019575..115118257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447530.1XP_024303298.1  tenascin isoform X1

      Conserved Domains (3) summary
      pfam00147
      Location:21632372
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
      pfam00041
      Location:20712143
      fn3; Fibronectin type III domain
    2. XM_005251975.4XP_005252032.1  tenascin isoform X16

      UniProtKB/Swiss-Prot
      P24821
      Related
      ENSP00000443478.1, OTTHUMP00000237695, ENST00000537320.5
      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:12511323
      fn3; Fibronectin type III domain
      pfam00147
      Location:13431552
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    3. XM_005251974.4XP_005252031.1  tenascin isoform X14

      UniProtKB/Swiss-Prot
      P24821
      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:13421414
      fn3; Fibronectin type III domain
      pfam00147
      Location:14341643
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    4. XM_011518629.3XP_011516931.1  tenascin isoform X12

      UniProtKB/Swiss-Prot
      P24821
      Conserved Domains (5) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:14331505
      fn3; Fibronectin type III domain
      pfam00147
      Location:15251734
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
      cl19567
      Location:486527
      DSL; Delta serrate ligand
    5. XM_011518626.3XP_011516928.1  tenascin isoform X10

      Related
      ENSP00000438152.2, ENST00000535648.5
      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:16161688
      fn3; Fibronectin type III domain
      pfam00147
      Location:17081917
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    6. XM_017014681.2XP_016870170.1  tenascin isoform X7

    7. XM_006717101.4XP_006717164.1  tenascin isoform X15

      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:13421414
      fn3; Fibronectin type III domain
      pfam00147
      Location:14341643
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    8. XM_011518628.3XP_011516930.1  tenascin isoform X13

      Conserved Domains (5) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:14331505
      fn3; Fibronectin type III domain
      pfam00147
      Location:15251734
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
      cl19567
      Location:486527
      DSL; Delta serrate ligand
    9. XM_006717098.4XP_006717161.1  tenascin isoform X8

      UniProtKB/TrEMBL
      J3QSU6
      Related
      ENSP00000339553.4, OTTHUMP00000237669, ENST00000341037.8
      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:17061778
      fn3; Fibronectin type III domain
      pfam00147
      Location:17982007
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    10. XM_006717097.4XP_006717160.1  tenascin isoform X6

      Conserved Domains (3) summary
      pfam00041
      Location:17971869
      fn3; Fibronectin type III domain
      pfam00147
      Location:18892098
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    11. XM_017014679.2XP_016870168.1  tenascin isoform X3

    12. XM_005251973.4XP_005252030.1  tenascin isoform X11

      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:15241596
      fn3; Fibronectin type III domain
      pfam00147
      Location:16161825
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    13. XM_011518625.3XP_011516927.1  tenascin isoform X9

      Related
      ENSP00000411406.2, OTTHUMP00000237658, ENST00000423613.6
      Conserved Domains (3) summary
      pfam00041
      Location:17061778
      fn3; Fibronectin type III domain
      pfam00147
      Location:17982007
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    14. XM_005251972.4XP_005252029.1  tenascin isoform X5

      UniProtKB/Swiss-Prot
      P24821
      Conserved Domains (3) summary
      pfam00041
      Location:17971869
      fn3; Fibronectin type III domain
      pfam00147
      Location:18892098
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    15. XM_006717096.4XP_006717159.1  tenascin isoform X2

      Conserved Domains (3) summary
      pfam00041
      Location:19802052
      fn3; Fibronectin type III domain
      pfam00147
      Location:20722281
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    16. XM_017014680.2XP_016870169.1  tenascin isoform X4

    17. XM_017014678.2XP_016870167.1  tenascin isoform X1

      Conserved Domains (3) summary
      pfam00147
      Location:21632372
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
      pfam00041
      Location:20712143
      fn3; Fibronectin type III domain
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