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    Smo smoothened, frizzled class receptor [ Mus musculus (house mouse) ]

    Gene ID: 319757, updated on 11-Dec-2018

    Summary

    Official Symbol
    Smoprovided by MGI
    Official Full Name
    smoothened, frizzled class receptorprovided by MGI
    Primary source
    MGI:MGI:108075
    See related
    Ensembl:ENSMUSG00000001761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bnb; Smoh; smoothened; E130215L21Rik
    Expression
    Broad expression in ovary adult (RPKM 53.2), limb E14.5 (RPKM 37.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See Smo in Genome Data Viewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (29735497..29761366)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (29685497..29711366)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38780 Neighboring gene tetraspanin 33 Neighboring gene predicted gene 13717 Neighboring gene S-adenosylhomocysteine hydrolase-like 2 Neighboring gene striatin interacting protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Activation of SMO, organism-specific biosystem (from REACTOME)
      Activation of SMO, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Hedgehog 'off' state, organism-specific biosystem (from REACTOME)
      Hedgehog 'off' state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Hedgehog 'on' state, organism-specific biosystem (from REACTOME)
      Hedgehog 'on' state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, pre...
    • Hedgehog signaling, organism-specific biosystem (from KEGG)
      Hedgehog signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Hedgehog signaling, conserved biosystem (from KEGG)
      Hedgehog signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
      Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
    • Hedgehog signaling pathway, conserved biosystem (from KEGG)
      Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
    • Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
      Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
      Signaling by Hedgehog, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    patched binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    patched binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    astrocyte activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    atrial septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon extension involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cholesterol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    central nervous system neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar cortex morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    commissural neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    commissural neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of cell density by contact stimulus involved in contact inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    determination of left/right asymmetry in lateral mesoderm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral neural tube patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic organ development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epithelial-mesenchymal cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    homeostasis of number of cells within a tissue IDA
    Inferred from Direct Assay
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    left/right axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal to epithelial transition involved in metanephric renal vesicle formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    midgut development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural crest cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pancreas morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hh target transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein import into nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smoothened signaling pathway involved in ventral spinal cord patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thalamus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    type B pancreatic cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventral midline determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    smoothened homolog
    Names
    bent body

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176996.4NP_795970.3  smoothened homolog precursor

      See identical proteins and their annotated locations for NP_795970.3

      Status: VALIDATED

      Source sequence(s)
      AC069469, AK081050, AW555326, BB659739, CA749812, CN665198
      Consensus CDS
      CCDS19965.1
      UniProtKB/Swiss-Prot
      P56726
      UniProtKB/TrEMBL
      Q4VBD5, Q8BJN8
      Related
      ENSMUSP00000001812.4, ENSMUST00000001812.4
      Conserved Domains (2) summary
      cd07451
      Location:70200
      CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
      pfam01534
      Location:225554
      Frizzled; Frizzled/Smoothened family membrane region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      29735497..29761366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505106.3XP_006505169.1  smoothened homolog isoform X1

      Conserved Domains (2) summary
      pfam01534
      Location:91420
      Frizzled; Frizzled/Smoothened family membrane region
      cl02447
      Location:166
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
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