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    HMGN2 high mobility group nucleosomal binding domain 2 [ Homo sapiens (human) ]

    Gene ID: 3151, updated on 19-May-2018
    Official Symbol
    HMGN2provided by HGNC
    Official Full Name
    high mobility group nucleosomal binding domain 2provided by HGNC
    Primary source
    HGNC:HGNC:4986
    See related
    Ensembl:ENSG00000198830 MIM:163910; Vega:OTTHUMG00000003555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMG17
    Summary
    The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 279.3), lymph node (RPKM 141.8) and 25 other tissues See more
    Orthologs
    See HMGN2 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (26472411..26476642)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26798902..26803133)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dehydrodolichyl diphosphate synthase subunit Neighboring gene uncharacterized LOC101928324 Neighboring gene ribosomal protein L17 pseudogene 9 Neighboring gene developmental pluripotency associated 2 pseudogene 2 Neighboring gene ribosomal protein S6 kinase A1 Neighboring gene microRNA 1976

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies transcription regulatory and chromatin remodeling factors LEDGF/p75, KAP1, BTF3b, THRAP3, and HMGN2 as IN-binding partners PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC5629, MGC88718

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    nucleosomal DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    antimicrobial humoral immune response mediated by antimicrobial peptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    killing of cells of other organism IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    non-histone chromosomal protein HMG-17
    Names
    high mobility group nucleosome-binding domain-containing protein 2
    high mobility group protein N2
    high-mobility group (nonhistone chromosomal) protein 17
    nonhistone chromosomal protein HMG-17

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005517.3NP_005508.1  non-histone chromosomal protein HMG-17

      See identical proteins and their annotated locations for NP_005508.1

      Status: REVIEWED

      Source sequence(s)
      AL513365, AU100588, BC071707, BC110390, BU074476
      Consensus CDS
      CCDS283.1
      UniProtKB/Swiss-Prot
      P05204
      Related
      ENSP00000355228.5, OTTHUMP00000003669, ENST00000361427.5, OTTHUMT00000009901
      Conserved Domains (1) summary
      pfam01101
      Location:188
      HMG14_17; HMG14 and HMG17

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      26472411..26476642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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