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    ADGRE2 adhesion G protein-coupled receptor E2 [ Homo sapiens (human) ]

    Gene ID: 30817, updated on 2-Oct-2018

    Summary

    Official Symbol
    ADGRE2provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor E2provided by HGNC
    Primary source
    HGNC:HGNC:3337
    See related
    Ensembl:ENSG00000127507 MIM:606100; Vega:OTTHUMG00000183408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VBU; CD97; EMR2; CD312
    Summary
    This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
    Expression
    Broad expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 16 other tissues See more
    Orthologs

    Genomic context

    See ADGRE2 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (14732697..14778541, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14843509..14889353, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E3 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene uncharacterized LOC107985308 Neighboring gene zinc finger protein 333 Neighboring gene transmembrane protein 167A pseudogene Neighboring gene olfactory receptor family 7 subfamily C member 1 Neighboring gene olfactory receptor family 7 subfamily A member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
      Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp781B135

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    chondroitin sulfate binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    granulocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    leading edge membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor E2
    Names
    CD97 antigen
    EGF-like module-containing mucin-like hormone receptor-like 2
    Leukocyte antigen CD97
    egf-like module containing, mucin-like, hormone receptor-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047146.1 RefSeqGene

      Range
      5001..50845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001271052.1NP_001257981.1  adhesion G protein-coupled receptor E2 isoform h precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
      Source sequence(s)
      AC005327, AC090427, AK298700, BC127004, CN480316
      Consensus CDS
      CCDS59361.1
      UniProtKB/Swiss-Prot
      Q9UHX3
      UniProtKB/TrEMBL
      A0JNV7
      Related
      ENSP00000376692.3, OTTHUMP00000271622, ENST00000392965.7, OTTHUMT00000466503
      Conserved Domains (3) summary
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163210
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:475716
      7tm_4; Olfactory receptor
    2. NM_013447.3NP_038475.2  adhesion G protein-coupled receptor E2 isoform a precursor

      See identical proteins and their annotated locations for NP_038475.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC090427, AK298700, BC127004, BG721006, CN480316
      Consensus CDS
      CCDS32935.1
      UniProtKB/Swiss-Prot
      Q9UHX3
      UniProtKB/TrEMBL
      A0JNV7
      Related
      ENSP00000319883.3, OTTHUMP00000271621, ENST00000315576.7, OTTHUMT00000466502
      Conserved Domains (4) summary
      smart00303
      Location:479529
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163210
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:533774
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      14732697..14778541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026726.1XP_016882215.1  adhesion G protein-coupled receptor E2 isoform X3

    2. XM_011527954.3XP_011526256.1  adhesion G protein-coupled receptor E2 isoform X8

      Conserved Domains (4) summary
      smart00303
      Location:366416
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:641
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:5097
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:420661
      7tm_4; Olfactory receptor
    3. XM_017026727.1XP_016882216.1  adhesion G protein-coupled receptor E2 isoform X7

    4. XM_011527951.3XP_011526253.1  adhesion G protein-coupled receptor E2 isoform X4

      Related
      ENSP00000470725.1, OTTHUMP00000271623, ENST00000594294.5
      Conserved Domains (4) summary
      smart00303
      Location:430480
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163197
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:484725
      7tm_4; Olfactory receptor
    5. XM_011527949.2XP_011526251.1  adhesion G protein-coupled receptor E2 isoform X2

      Related
      ENSP00000472280.2, OTTHUMP00000271620, ENST00000596991.6, OTTHUMT00000466500
      Conserved Domains (4) summary
      smart00303
      Location:468518
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163210
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:522763
      7tm_4; Olfactory receptor
    6. XM_011527952.3XP_011526254.1  adhesion G protein-coupled receptor E2 isoform X5

      Conserved Domains (3) summary
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163210
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:475716
      7tm_4; Olfactory receptor
    7. XM_011527948.2XP_011526250.1  adhesion G protein-coupled receptor E2 isoform X1

      Conserved Domains (4) summary
      smart00303
      Location:479529
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163210
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:533774
      7tm_4; Olfactory receptor
    8. XM_011527953.2XP_011526255.1  adhesion G protein-coupled receptor E2 isoform X6

      Related
      ENSP00000472735.1, OTTHUMP00000271624, ENST00000594076.5, OTTHUMT00000466505
      Conserved Domains (3) summary
      smart00303
      Location:386436
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam07645
      Location:119153
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:440681
      7tm_4; Olfactory receptor
    9. XM_011527955.2XP_011526257.1  adhesion G protein-coupled receptor E2 isoform X9

      Conserved Domains (3) summary
      smart00303
      Location:280330
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam07645
      Location:1347
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:334575
      7tm_4; Olfactory receptor

    RNA

    1. XR_936174.1 RNA Sequence

    2. XR_001753675.1 RNA Sequence

    3. XR_936173.1 RNA Sequence

    4. XR_001753674.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152916.1: Suppressed sequence

      Description
      NM_152916.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_152917.1: Suppressed sequence

      Description
      NM_152917.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    3. NM_152918.1: Suppressed sequence

      Description
      NM_152918.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    4. NM_152919.1: Suppressed sequence

      Description
      NM_152919.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    5. NM_152920.1: Suppressed sequence

      Description
      NM_152920.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    6. NM_152921.1: Suppressed sequence

      Description
      NM_152921.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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