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    HCRTR1 hypocretin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 3061, updated on 12-May-2019

    Summary

    Official Symbol
    HCRTR1provided by HGNC
    Official Full Name
    hypocretin receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:4848
    See related
    Ensembl:ENSG00000121764 MIM:602392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OX1R
    Summary
    The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See HCRTR1 in Genome Data Viewer
    Location:
    1p35.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (31617700..31632518)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32083290..32093214)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1226 Neighboring gene uncharacterized LOC105378626 Neighboring gene tubulointerstitial nephritis antigen like 1 Neighboring gene uncharacterized LOC107985471 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene uncharacterized LOC105378628 Neighboring gene collagen type XVI alpha 1 chain Neighboring gene uncharacterized LOC101929444

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    orexin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    orexin receptor type 1
    Names
    hypocretin (orexin) receptor 1
    hypocretin receptor type 1
    orexin receptor 1
    ox-1-R
    ox1-R

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001525.2NP_001516.2  orexin receptor type 1

      See identical proteins and their annotated locations for NP_001516.2

      Status: REVIEWED

      Source sequence(s)
      AK290521, BC074796, CO960455, DA803650
      Consensus CDS
      CCDS344.1
      UniProtKB/Swiss-Prot
      O43613
      Related
      ENSP00000384387.2, ENST00000403528.6
      Conserved Domains (1) summary
      cd15208
      Location:47369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      31617700..31632518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446603.1XP_024302371.1  orexin receptor type 1 isoform X1

      Conserved Domains (1) summary
      cd15208
      Location:47369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_024446605.1XP_024302373.1  orexin receptor type 1 isoform X1

      Conserved Domains (1) summary
      cd15208
      Location:47369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_017001107.1XP_016856596.1  orexin receptor type 1 isoform X2

      UniProtKB/TrEMBL
      A6NMV7
      Related
      ENSP00000362809.1, ENST00000373705.1
    4. XM_024446602.1XP_024302370.1  orexin receptor type 1 isoform X1

      Related
      ENSP00000362810.5, ENST00000373706.9
      Conserved Domains (1) summary
      cd15208
      Location:47369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. XM_024446604.1XP_024302372.1  orexin receptor type 1 isoform X1

      Conserved Domains (1) summary
      cd15208
      Location:47369
      7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
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