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    UBQLN2 ubiquilin 2 [ Homo sapiens (human) ]

    Gene ID: 29978, updated on 5-Aug-2018

    Summary

    Official Symbol
    UBQLN2provided by HGNC
    Official Full Name
    ubiquilin 2provided by HGNC
    Primary source
    HGNC:HGNC:12509
    See related
    Ensembl:ENSG00000188021 MIM:300264; Vega:OTTHUMG00000021669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSK2; ALS15; CHAP1; N4BP4; PLIC2; HRIHFB2157
    Summary
    This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
    Orthologs

    Genomic context

    See UBQLN2 in Genome Data Viewer
    Location:
    Xp11.21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (56563593..56567010)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (56590025..56593443)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) pseudogene Neighboring gene Kruppel like factor 8 Neighboring gene ribosomal protein L23a pseudogene 83 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 1 Neighboring gene negative regulator of P-body association Neighboring gene spindlin family member 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ubiquilin 2 (UBQLN2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10167, FLJ56541

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    ubiquilin-2
    Names
    Nedd4 binding protein 4
    protein linking IAP with cytoskeleton 2
    ubiquitin-like product Chap1/Dsk2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016249.1 RefSeqGene

      Range
      5001..8418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_665

    mRNA and Protein(s)

    1. NM_013444.3NP_038472.2  ubiquilin-2

      See identical proteins and their annotated locations for NP_038472.2

      Status: REVIEWED

      Source sequence(s)
      AF189009, AU310783, BC069237, BI602998
      Consensus CDS
      CCDS14374.1
      UniProtKB/Swiss-Prot
      Q9UHD9
      Related
      ENSP00000345195.5, OTTHUMP00000023408, ENST00000338222.6, OTTHUMT00000056891
      Conserved Domains (4) summary
      smart00727
      Location:382426
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:33103
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:33103
      UBQ; Ubiquitin homologues
      cd14399
      Location:581620
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      56563593..56567010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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