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    TMOD3 tropomodulin 3 [ Homo sapiens (human) ]

    Gene ID: 29766, updated on 4-Nov-2018

    Summary

    Official Symbol
    TMOD3provided by HGNC
    Official Full Name
    tropomodulin 3provided by HGNC
    Primary source
    HGNC:HGNC:11873
    See related
    Ensembl:ENSG00000138594 MIM:605112; Vega:OTTHUMG00000131803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UTMOD
    Expression
    Ubiquitous expression in esophagus (RPKM 45.0), lung (RPKM 23.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See TMOD3 in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (51829628..51912138)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52121825..52204335)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene LysM domain containing 2 Neighboring gene tropomodulin 2 Neighboring gene UTP6, small subunit (SSU) processome component, homolog (yeast) pseudogene Neighboring gene uncharacterized LOC112268148 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component pseudogene Neighboring gene RNA, U6 small nuclear 90, pseudogene Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
      Striated Muscle Contraction, organism-specific biosystemStriated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons....

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding involved in cell-cell adhesion HDA PubMed 
    tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pointed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell-cell adherens junction HDA PubMed 
    myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    tropomodulin-3
    Names
    tropomodulin 3 (ubiquitous)
    ubiquitous tropomodulin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014547.4NP_055362.1  tropomodulin-3

      See identical proteins and their annotated locations for NP_055362.1

      Status: VALIDATED

      Source sequence(s)
      AC090971, AL137543, BC020542, BM975185
      Consensus CDS
      CCDS10145.1
      UniProtKB/Swiss-Prot
      Q9NYL9
      Related
      ENSP00000308753.7, OTTHUMP00000162615, ENST00000308580.11, OTTHUMT00000254740
      Conserved Domains (2) summary
      pfam03250
      Location:5146
      Tropomodulin; Tropomodulin
      cl26161
      Location:216292
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      51829628..51912138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022087.1XP_016877576.1  tropomodulin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q9NYL9
      Conserved Domains (2) summary
      pfam03250
      Location:5146
      Tropomodulin; Tropomodulin
      cl26161
      Location:216292
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. XM_017022088.1XP_016877577.1  tropomodulin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q9NYL9
      Conserved Domains (2) summary
      pfam03250
      Location:5146
      Tropomodulin; Tropomodulin
      cl26161
      Location:216292
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
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