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    TMOD4 tropomodulin 4 [ Homo sapiens (human) ]

    Gene ID: 29765, updated on 2-Oct-2018

    Summary

    Official Symbol
    TMOD4provided by HGNC
    Official Full Name
    tropomodulin 4provided by HGNC
    Primary source
    HGNC:HGNC:11874
    See related
    Ensembl:ENSG00000163157 MIM:605834; Vega:OTTHUMG00000012350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SK-TMOD
    Expression
    Biased expression in prostate (RPKM 6.3), esophagus (RPKM 3.1) and 4 other tissues See more
    Orthologs

    Genomic context

    See TMOD4 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (151169986..151176071, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151142463..151148547, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene semaphorin 6C Neighboring gene TNFAIP8L2-SCNM1 readthrough Neighboring gene LysM domain containing 1 Neighboring gene TNF alpha induced protein 8 like 2 Neighboring gene sodium channel modifier 1 Neighboring gene vacuolar protein sorting 72 homolog Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Pathways from BioSystems

    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
      Striated Muscle Contraction, organism-specific biosystemStriated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons....

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp779I0852

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pointed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tropomodulin-4
    Names
    actin-capping protein
    skeletal muscle tropomodulin
    skeletal tropomodulin
    tropomodulin 4 (muscle)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013353.2NP_037485.2  tropomodulin-4

      See identical proteins and their annotated locations for NP_037485.2

      Status: VALIDATED

      Source sequence(s)
      AF177173, DC385872
      Consensus CDS
      CCDS988.1
      UniProtKB/Swiss-Prot
      Q9NZQ9
      Related
      ENSP00000295314.4, OTTHUMP00000014288, ENST00000295314.8, OTTHUMT00000034419
      Conserved Domains (2) summary
      pfam03250
      Location:4143
      Tropomodulin; Tropomodulin
      cl26161
      Location:184286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      151169986..151176071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509449.1XP_011507751.1  tropomodulin-4 isoform X1

      See identical proteins and their annotated locations for XP_011507751.1

      UniProtKB/Swiss-Prot
      Q9NZQ9
      Conserved Domains (2) summary
      pfam03250
      Location:4143
      Tropomodulin; Tropomodulin
      cl26161
      Location:184286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. XM_017001090.2XP_016856579.1  tropomodulin-4 isoform X2

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