Format

Send to:

Choose Destination
    • Showing Current items.

    GTF2F2 general transcription factor IIF subunit 2 [ Homo sapiens (human) ]

    Gene ID: 2963, updated on 5-Aug-2018

    Summary

    Official Symbol
    GTF2F2provided by HGNC
    Official Full Name
    general transcription factor IIF subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:4653
    See related
    Ensembl:ENSG00000188342 MIM:189969; Vega:OTTHUMG00000016849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTF4; RAP30; TF2F2; TFIIF
    Expression
    Ubiquitous expression in skin (RPKM 5.5), adrenal (RPKM 5.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See GTF2F2 in Genome Data Viewer
    Location:
    13q14.12-q14.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (45119830..45284105)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45694631..45858240)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SK small nuclear pseudogene 3 Neighboring gene uncharacterized LOC101929259 Neighboring gene RNA, 7SK small nuclear pseudogene 4 Neighboring gene RNA, U6 small nuclear 69, pseudogene Neighboring gene potassium channel tetramerization domain containing 4 Neighboring gene uncharacterized LOC105370190 Neighboring gene small nucleolar RNA, H/ACA box 31B Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene tumor protein, translationally-controlled 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
    Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIF, during Tat-mediated transactivation of the HIV-1 LTR PubMed
    tat TFIIF synergizes with HIV-1 Tat and the cellular co-activator Tat-SF1 during Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
    tat HIV-1 Tat directly interacts with the RAP30 subunit of TFIIF as demonstrated by Tat-affinity column purification PubMed
    tat TFIIF is required for both basal and HIV-1 Tat-activated transcription PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus HDA PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFIIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcriptional preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    general transcription factor IIF subunit 2
    Names
    ATP-dependent helicase GTF2F2
    TFIIF-beta
    general transcription factor IIF 30 kDa subunit
    general transcription factor IIF, polypeptide 2, 30kDa
    transcription initiation factor IIF subunit beta
    transcription initiation factor RAP30
    NP_004119.1
    XP_011533354.1
    XP_011533355.1
    XP_016876039.1
    XP_016876040.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004128.2NP_004119.1  general transcription factor IIF subunit 2

      See identical proteins and their annotated locations for NP_004119.1

      Status: VALIDATED

      Source sequence(s)
      AK291545, BC001771, CA429230, CB124466, DB252856
      Consensus CDS
      CCDS9395.1
      UniProtKB/Swiss-Prot
      P13984
      UniProtKB/TrEMBL
      A0A024RDU9
      Related
      ENSP00000340823.6, OTTHUMP00000018348, ENST00000340473.7, OTTHUMT00000044767
      Conserved Domains (1) summary
      pfam02270
      Location:13236
      TFIIF_beta; Transcription initiation factor IIF, beta subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      45119830..45284105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020551.1XP_016876040.1  general transcription factor IIF subunit 2 isoform X3

    2. XM_011535052.3XP_011533354.1  general transcription factor IIF subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam02270
      Location:13262
      TFIIF_beta; Transcription initiation factor IIF, beta subunit
    3. XM_011535053.3XP_011533355.1  general transcription factor IIF subunit 2 isoform X4

      Conserved Domains (1) summary
      cd07980
      Location:5103
      TFIIF_beta; Transcription initiation factor IIF, beta subunit
    4. XM_017020550.2XP_016876039.1  general transcription factor IIF subunit 2 isoform X2

    Support Center