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    GSTM3 glutathione S-transferase mu 3 [ Homo sapiens (human) ]

    Gene ID: 2947, updated on 5-Aug-2018

    Summary

    Official Symbol
    GSTM3provided by HGNC
    Official Full Name
    glutathione S-transferase mu 3provided by HGNC
    Primary source
    HGNC:HGNC:4635
    See related
    Ensembl:ENSG00000134202 MIM:138390; Vega:OTTHUMG00000011640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GST5; GSTB; GTM3; GSTM3-3
    Summary
    Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
    Expression
    Broad expression in testis (RPKM 82.2), kidney (RPKM 34.8) and 16 other tissues See more
    Orthologs

    Genomic context

    See GSTM3 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (109733932..109741038, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110276554..110283660, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu 1 Neighboring gene glutathione S-transferase mu 5 Neighboring gene EPS8 like 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC3310, MGC3704

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    glutathione binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione transferase activity TAS
    Traceable Author Statement
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular detoxification of nitrogen compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment of blood-nerve barrier TAS
    Traceable Author Statement
    more info
    PubMed 
    glutathione derivative biosynthetic process TAS
    Traceable Author Statement
    more info
     
    glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nitrobenzene metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    xenobiotic catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    nucleus HDA PubMed 
    sperm fibrous sheath IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutathione S-transferase Mu 3
    Names
    GST class-mu 3
    S-(hydroxyalkyl)glutathione lyase M3
    brain GST
    brain type mu-glutathione S-transferase
    glutathione S-alkyltransferase M3
    glutathione S-aralkyltransferase M3
    glutathione S-aryltransferase M3
    glutathione S-transferase M3 (brain)
    glutathione S-transferase mu 3 (brain)
    glutathione S-transferase, Mu-3
    hGSTM3-3
    NP_000840.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000849.4NP_000840.2  glutathione S-transferase Mu 3

      See identical proteins and their annotated locations for NP_000840.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL158847, BC008790, BC030253
      Consensus CDS
      CCDS812.1
      UniProtKB/Swiss-Prot
      P21266
      UniProtKB/TrEMBL
      Q6FGJ9
      Related
      ENSP00000354357.2, OTTHUMP00000013355, ENST00000361066.6, OTTHUMT00000032182
      Conserved Domains (2) summary
      cd03209
      Location:96216
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:788
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RNA

    1. NR_024537.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a frameshift and early stop codon. The predicted protein is not represented because the product is significantly truncated and the transcript is likely to be a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      AK304300, AL158847, BC008790, BC030253

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      109733932..109741038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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