GSN gelsolin [Homo sapiens (human)] - Gene

Summary

Official Symbol: GSNprovided by HGNC
Official Full Name: gelsolinprovided by HGNC
Primary source: HGNC:HGNC:4620
See related: Ensembl:ENSG00000148180 MIM:137350; AllianceGenome:HGNC:4620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADF; AGEL; AMYLD4
Summary: The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in fat (RPKM 444.2), heart (RPKM 172.6) and 23 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9q33.2

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (121201483..121332842)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (133397510..133528852)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (123963761..124095120)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma.
Title: Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma.
The regulation of plasma gelsolin by DNA methylation in ovarian cancer chemo-resistance.
Title: The regulation of plasma gelsolin by DNA methylation in ovarian cancer chemo-resistance.
Gelsolin, an Actin-Binding Protein: Bioinformatic Analysis and Functional Significance in Urothelial Bladder Carcinoma.
Title: Gelsolin, an Actin-Binding Protein: Bioinformatic Analysis and Functional Significance in Urothelial Bladder Carcinoma.
mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
Title: mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
GSN gene frameshift mutations in Alzheimer's disease.
Title: GSN gene frameshift mutations in Alzheimer's disease.
Role and therapeutic potential of gelsolin in atherosclerosis.
Title: Role and therapeutic potential of gelsolin in atherosclerosis.
Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t(9;12)(q33;q14) Chromosomal Translocation.
Title: Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t(9;12)(q33;q14) Chromosomal Translocation.
HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.
Title: HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.
Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance.
Title: Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance.
Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment.
Title: Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment.

Submit: New GeneRIF Correction See all GeneRIFs (177)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Finnish type amyloidosis MedGen: C1622345 OMIM: 105120 GeneReviews: Not available	Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interaction	Pubs
Knockdown of gelsolin by siRNA inhibits early HIV-1 infection and HIV-1 Env (gp120/gp41)-mediated membrane fusion in permissive lymphocytes	PubMed

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes	PubMed
Tat	tat	In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of gelsolin (GSN) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed
	vpr	The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC	PubMed

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH66047 (e-PCR)
- UniSTS:25095

GSN (e-PCR)
- UniSTS:253982

SHGC-82301 (e-PCR)
- UniSTS:104242

SHGC-132035 (e-PCR)
- UniSTS:173882

STS-X04412 (e-PCR)
- UniSTS:16463

SHGC-37121 (e-PCR)
- UniSTS:33921

STS-AA029453 (e-PCR)
- UniSTS:34699

GDB:597556 (e-PCR)
- UniSTS:158100

G10520 (e-PCR)
- UniSTS:56986

MARC_23632-23633:1027531903:1 (e-PCR)
- UniSTS:268728

WI-18229 (e-PCR)
- UniSTS:5308

D9S323 (e-PCR)
- UniSTS:69060

D9S1953 (e-PCR)
- UniSTS:63945

D9S1050E (e-PCR)
- UniSTS:29132

RH17399 (e-PCR)
- UniSTS:34031

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin II binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol 3-kinase catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase catalytic subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in actin filament capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament capping	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament depolymerization	IEA Inferred from Electronic Annotation more info
involved_in actin filament organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament severing	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament severing	IEA Inferred from Electronic Annotation more info
involved_in actin filament severing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid fibril formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	TAS Traceable Author Statement more info	PubMed
involved_in cardiac muscle cell contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell contraction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in host-mediated suppression of symbiont invasion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of keratinocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein processing in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein processing in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of T cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of plasma membrane raft polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in relaxation of cardiac muscle	IEA Inferred from Electronic Annotation more info
involved_in relaxation of cardiac muscle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in renal protein absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to muscle stretch	IEA Inferred from Electronic Annotation more info
involved_in response to muscle stretch	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in striated muscle atrophy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cap	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
located_in actin cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in blood microparticle	HDA more info	PubMed
colocalizes_with cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in focal adhesion	HDA more info	PubMed
colocalizes_with focal adhesion	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
colocalizes_with nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: gelsolin

Names: actin-depolymerizing factor; brevin; epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012872.2 RefSeqGene

Range

72081..136761

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000177.5 → NP_000168.1 gelsolin isoform a precursor

See identical proteins and their annotated locations for NP_000168.1

Status: REVIEWED

Source sequence(s)

BC026033, DB250757

Consensus CDS

CCDS6828.1

UniProtKB/Swiss-Prot

A2A418, A8MUD1, A8MYN7, B7Z373, B7Z5V1, F5H1A8, P06396, Q5T0I2, Q8WVV7

UniProtKB/TrEMBL

A0A384MEF1, B7Z9A0

Related

ENSP00000362924.4, ENST00000373818.8

Conserved Domains (6) summary

cd11288
Location:561 → 649

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:186 → 275

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:59 → 171

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:666 → 764

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:295 → 395

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:439 → 539

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001127662.2 → NP_001121134.1 gelsolin isoform b

See identical proteins and their annotated locations for NP_001121134.1

Status: REVIEWED

Source sequence(s)

AK096280, BC017491, DA450851

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000587292.1, ENST00000917233.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001127663.2 → NP_001121135.2 gelsolin isoform f

Status: REVIEWED

Source sequence(s)

AK096280, BC017491, DA294394, DA394782

Consensus CDS

CCDS75890.1

UniProtKB/TrEMBL

A0A0A0MT01, B7Z6N2

Related

ENSP00000409358.2, ENST00000449733.7

Conserved Domains (6) summary

cd11288
Location:546 → 634

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:171 → 260

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:44 → 156

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:651 → 749

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:280 → 380

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:424 → 524

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001127664.2 → NP_001121136.1 gelsolin isoform b

See identical proteins and their annotated locations for NP_001121136.1

Status: REVIEWED

Source sequence(s)

AK096280, BC017491, DA294394, DB170452

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570593.1, ENST00000900534.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001127665.2 → NP_001121137.1 gelsolin isoform b

See identical proteins and their annotated locations for NP_001121137.1

Status: REVIEWED

Source sequence(s)

AK096280, BC017491, DC370937

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570591.1, ENST00000900532.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001127666.2 → NP_001121138.1 gelsolin isoform c

See identical proteins and their annotated locations for NP_001121138.1

Status: REVIEWED

Source sequence(s)

AK096280, BC017491, DC341948

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000362914.3, ENST00000373808.8

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001127667.2 → NP_001121139.1 gelsolin isoform c

See identical proteins and their annotated locations for NP_001121139.1

Status: REVIEWED

Source sequence(s)

AK096280, BC017491, DC316173

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001258029.2 → NP_001244958.1 gelsolin isoform d

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS75891.1

UniProtKB/TrEMBL

A0A0A0MS51, B7Z992

Related

ENSP00000377882.3, ENST00000394353.7

Conserved Domains (6) summary

cd11288
Location:527 → 615

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:152 → 241

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:25 → 137

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:632 → 730

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:261 → 361

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:405 → 505

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001258030.2 → NP_001244959.1 gelsolin isoform e

Status: REVIEWED

Source sequence(s)

AK295572, AK299453, AL513122, BC017491, DC378873

Consensus CDS

CCDS65118.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000445823.1, ENST00000545652.6

Conserved Domains (6) summary

cd11288
Location:518 → 606

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:143 → 232

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:16 → 128

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:623 → 721

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:252 → 352

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:396 → 496

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353053.1 → NP_001339982.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL137068, AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570581.1, ENST00000900522.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353054.1 → NP_001339983.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL137068, AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000362929.2, ENST00000373823.7

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353055.2 → NP_001339984.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570590.1, ENST00000900531.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353056.2 → NP_001339985.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570592.1, ENST00000900533.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353057.2 → NP_001339986.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570589.1, ENST00000900530.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353058.2 → NP_001339987.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570647.1, ENST00000900588.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353059.2 → NP_001339988.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570603.1, ENST00000900544.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353060.2 → NP_001339989.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570595.1, ENST00000900536.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353061.2 → NP_001339990.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570596.1, ENST00000900537.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353062.1 → NP_001339991.1 gelsolin isoform b

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000570652.1, ENST00000900593.1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353063.2 → NP_001339992.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353064.2 → NP_001339993.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353065.2 → NP_001339994.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353066.2 → NP_001339995.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353067.2 → NP_001339996.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000642640.1, ENST00000972581.1

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353068.2 → NP_001339997.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353069.2 → NP_001339998.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353070.2 → NP_001339999.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353071.2 → NP_001340000.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353072.2 → NP_001340001.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353073.2 → NP_001340002.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353074.2 → NP_001340003.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353075.1 → NP_001340004.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353076.2 → NP_001340005.1 gelsolin isoform g

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS94475.1

UniProtKB/TrEMBL

A0A8V8TND7, B7Z9A0

Related

ENSP00000514432.1, ENST00000699558.1

Conserved Domains (6) summary

cd11288
Location:534 → 622

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:159 → 248

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:32 → 144

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:639 → 737

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:268 → 368

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:412 → 512

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353077.1 → NP_001340006.1 gelsolin isoform c

Status: REVIEWED

Source sequence(s)

AL513122

Consensus CDS

CCDS48011.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001353078.2 → NP_001340007.1 gelsolin isoform h

Status: REVIEWED

Source sequence(s)

AL513122

UniProtKB/TrEMBL

B3KS49

Conserved Domains (4) summary

cd11288
Location:292 → 380

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:397 → 495

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:26 → 126

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:170 → 270

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_198252.3 → NP_937895.1 gelsolin isoform b

See identical proteins and their annotated locations for NP_937895.1

Status: REVIEWED

Source sequence(s)

AK096280, BC017491

Consensus CDS

CCDS6829.1

UniProtKB/TrEMBL

B7Z992

Related

ENSP00000404226.2, ENST00000432226.7

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:244 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

121201483..121332842

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047423273.1 → XP_047279229.1 gelsolin isoform X5

UniProtKB/TrEMBL

B7Z992
XM_047423267.1 → XP_047279223.1 gelsolin isoform X4

UniProtKB/TrEMBL

B7Z992
XM_047423268.1 → XP_047279224.1 gelsolin isoform X4

UniProtKB/TrEMBL

B7Z992
XM_047423272.1 → XP_047279228.1 gelsolin isoform X5

UniProtKB/TrEMBL

B7Z992
XM_047423265.1 → XP_047279221.1 gelsolin isoform X1

UniProtKB/TrEMBL

B7Z6N2
XM_017014645.2 → XP_016870134.1 gelsolin isoform X3

UniProtKB/TrEMBL

B7Z9A0

Conserved Domains (6) summary

cd11288
Location:531 → 619

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:156 → 245

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:29 → 141

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:636 → 734

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:265 → 365

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:409 → 509

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
XM_047423271.1 → XP_047279227.1 gelsolin isoform X4

UniProtKB/TrEMBL

B7Z992
XM_011518585.2 → XP_011516887.1 gelsolin isoform X2

UniProtKB/TrEMBL

B7Z9A0

Conserved Domains (6) summary

cd11288
Location:540 → 628

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:165 → 254

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:38 → 150

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:645 → 743

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:274 → 374

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:418 → 518

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
XM_047423270.1 → XP_047279226.1 gelsolin isoform X4

UniProtKB/TrEMBL

B7Z992
XM_047423266.1 → XP_047279222.1 gelsolin isoform X3

UniProtKB/TrEMBL

B7Z9A0
XM_047423269.1 → XP_047279225.1 gelsolin isoform X4

UniProtKB/TrEMBL

B7Z992
XM_005251944.2 → XP_005252001.1 gelsolin isoform X4

See identical proteins and their annotated locations for XP_005252001.1

UniProtKB/TrEMBL

B7Z992

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:255 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
XM_011518594.2 → XP_011516896.1 gelsolin isoform X6

Conserved Domains (5) summary

cd11288
Location:352 → 440

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:457 → 555

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:86 → 186

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:230 → 330

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

cl15697
Location:12 → 66

ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains