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    GSN gelsolin [ Homo sapiens (human) ]

    Gene ID: 2934, updated on 8-Oct-2018

    Summary

    Official Symbol
    GSNprovided by HGNC
    Official Full Name
    gelsolinprovided by HGNC
    Primary source
    HGNC:HGNC:4620
    See related
    Ensembl:ENSG00000148180 MIM:137350; Vega:OTTHUMG00000020584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADF; AGEL
    Summary
    The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 444.2), heart (RPKM 172.6) and 23 other tissues See more
    Orthologs

    Genomic context

    See GSN in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (121201483..121332844)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (124030380..124095122)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene C5 3'UTR overlapping transcript 1 Neighboring gene complement C5 Neighboring gene centriolin Neighboring gene RAB14, member RAS oncogene family Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene ATPase H+ transporting V1 subunit B2 pseudogene Neighboring gene GSN antisense RNA 1 Neighboring gene uncharacterized LOC102723324 Neighboring gene stomatin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of gelsolin by siRNA inhibits early HIV-1 infection and HIV-1 Env (gp120/gp41)-mediated membrane fusion in permissive lymphocytes PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes PubMed
    Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of gelsolin (GSN) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp313L0718

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myosin II binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin filament capping ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament reorganization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    actin filament severing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament severing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin filament severing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    amyloid fibril formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    cellular response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-gamma IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    oligodendrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of keratinocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein processing in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of establishment of T cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of plasma membrane raft polarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal protein absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to folic acid IEA
    Inferred from Electronic Annotation
    more info
     
    sequestering of actin monomers IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    striated muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cap IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    blood microparticle HDA PubMed 
    cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region HDA PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    focal adhesion HDA PubMed 
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    sarcoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    gelsolin
    Names
    actin-depolymerizing factor
    brevin
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012872.2 RefSeqGene

      Range
      72021..136761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000177.4NP_000168.1  gelsolin isoform a precursor

      See identical proteins and their annotated locations for NP_000168.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC026033, DB250757
      Consensus CDS
      CCDS6828.1
      UniProtKB/Swiss-Prot
      P06396
      Related
      ENSP00000362924.4, OTTHUMP00000022011, ENST00000373818.8, OTTHUMT00000053861
      Conserved Domains (6) summary
      cd11288
      Location:561649
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:186275
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:59171
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:666764
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:295395
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:439539
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    2. NM_001127662.1NP_001121134.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_001121134.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2, 3, 5, 6, and 11-20 all encode isoform b.
      Source sequence(s)
      AK096280, BC017491, DA294394, DA450851
      Consensus CDS
      CCDS6829.1
      UniProtKB/Swiss-Prot
      P06396
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    3. NM_001127663.1NP_001121135.2  gelsolin isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK096280, BC017491, DA294394, DA394782
      Consensus CDS
      CCDS75890.1
      UniProtKB/Swiss-Prot
      P06396
      UniProtKB/TrEMBL
      A0A0A0MT01
      Related
      ENSP00000409358.2, ENST00000449733.7
      Conserved Domains (6) summary
      cd11288
      Location:546634
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:171260
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:44156
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:651749
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:280380
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:424524
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    4. NM_001127664.1NP_001121136.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_001121136.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2, 3, 5, 6, and 11-20 all encode isoform b.
      Source sequence(s)
      AK096280, BC017491, DA294394, DB170452
      Consensus CDS
      CCDS6829.1
      UniProtKB/Swiss-Prot
      P06396
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    5. NM_001127665.1NP_001121137.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_001121137.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2, 3, 5, 6, and 11-20 all encode isoform b.
      Source sequence(s)
      AK096280, BC017491, DA294394, DC370937
      Consensus CDS
      CCDS6829.1
      UniProtKB/Swiss-Prot
      P06396
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    6. NM_001127666.1NP_001121138.1  gelsolin isoform c

      See identical proteins and their annotated locations for NP_001121138.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 7, 8, 21-33, and 35 all encode isoform c.
      Source sequence(s)
      AK096280, BC017491, DA294394, DC341948
      Consensus CDS
      CCDS48011.1
      UniProtKB/Swiss-Prot
      P06396
      Related
      ENSP00000362914.3, ENST00000373808.8
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    7. NM_001127667.1NP_001121139.1  gelsolin isoform c

      See identical proteins and their annotated locations for NP_001121139.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 7, 8, 21-33, and 35 all encode isoform c.
      Source sequence(s)
      AK096280, BC017491, DA294394, DC316173
      Consensus CDS
      CCDS48011.1
      UniProtKB/Swiss-Prot
      P06396
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    8. NM_001258029.1NP_001244958.1  gelsolin isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate first exon compared to that of variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK295572, AK297870, BC017491, DA823796
      Consensus CDS
      CCDS75891.1
      UniProtKB/Swiss-Prot
      P06396
      UniProtKB/TrEMBL
      A0A0A0MS51, B7Z4U6
      Related
      ENSP00000377882.3, OTTHUMP00000281153, ENST00000394353.7, OTTHUMT00000488009
      Conserved Domains (6) summary
      cd11288
      Location:527615
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:152241
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:25137
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:632730
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:261361
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:405505
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    9. NM_001258030.1NP_001244959.1  gelsolin isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate first exon compared to that of variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK295572, AK299453, BC017491, DC378873
      Consensus CDS
      CCDS65118.1
      UniProtKB/Swiss-Prot
      P06396
      Related
      ENSP00000445823.1, OTTHUMP00000281154, ENST00000545652.6, OTTHUMT00000488010
      Conserved Domains (6) summary
      cd11288
      Location:518606
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:143232
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:16128
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:623721
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:252352
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:396496
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    10. NM_001353053.1NP_001339982.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 2, 3, 5, 6, and 12-20, encodes isoform b.
      Source sequence(s)
      AL137068, AL513122
      Consensus CDS
      CCDS6829.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    11. NM_001353054.1NP_001339983.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 2, 3, 5, 6, 11, and 13-20, encodes isoform b.
      Source sequence(s)
      AL137068, AL513122
      Consensus CDS
      CCDS6829.1
      Related
      ENSP00000362929.2, ENST00000373823.7
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    12. NM_001353055.1NP_001339984.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 2, 3, 5, 6, 11, 12, and 14-20, encodes isoform b.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    13. NM_001353056.1NP_001339985.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 2, 3, 5, 6, 11-13, and 15-20, encodes isoform b.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    14. NM_001353057.1NP_001339986.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 2, 3, 5, 6, 11-14, and 16-20, encodes isoform b.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    15. NM_001353058.1NP_001339987.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 2, 3, 5, 6, 11-15, and 17-20, encodes isoform b.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    16. NM_001353059.1NP_001339988.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 2, 3, 5, 6, 11-16, and 18-20, encodes isoform b.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    17. NM_001353060.1NP_001339989.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 2, 3, 5, 6, 11-17, 19, and 20, encodes isoform b.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    18. NM_001353061.1NP_001339990.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 2, 3, 5, 6, 11-18, and 20, encodes isoform b.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    19. NM_001353062.1NP_001339991.1  gelsolin isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 2, 3, 5, 6, and 11-19, encodes isoform b.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    20. NM_001353063.1NP_001339992.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 7, 8, 22-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    21. NM_001353064.1NP_001339993.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 7, 8, 21, 23-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    22. NM_001353065.1NP_001339994.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 7, 8, 21, 22, 24-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    23. NM_001353066.1NP_001339995.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 7, 8, 21-23, 25-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    24. NM_001353067.1NP_001339996.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 7, 8, 21-24, 26-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    25. NM_001353068.1NP_001339997.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 7, 8, 21-25, 27-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    26. NM_001353069.1NP_001339998.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 7, 8, 21-26, 28-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    27. NM_001353070.1NP_001339999.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variants 7, 8, 21-27, 29-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    28. NM_001353071.1NP_001340000.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 7, 8, 21-28, 30-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    29. NM_001353072.1NP_001340001.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 7, 8, 21-29, 31-33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    30. NM_001353073.1NP_001340002.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variants 7, 8, 21-30, 32, 33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    31. NM_001353074.1NP_001340003.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 7, 8, 21-31, 33, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    32. NM_001353075.1NP_001340004.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variants 7, 8, 21-32, and 35, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    33. NM_001353076.1NP_001340005.1  gelsolin isoform g

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Conserved Domains (6) summary
      cd11288
      Location:534622
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:159248
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:32144
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:639737
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:268368
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:412512
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    34. NM_001353077.1NP_001340006.1  gelsolin isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (35), as well as variants 7, 8, and 21-33, encodes isoform c.
      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    35. NM_001353078.1NP_001340007.1  gelsolin isoform h

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Conserved Domains (4) summary
      cd11288
      Location:292380
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:397495
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:26126
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:170270
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    36. NM_198252.2NP_937895.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_937895.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2, 3, 5, 6, and 11-20 all encode isoform b.
      Source sequence(s)
      AK096280, BC017491, DA294394
      Consensus CDS
      CCDS6829.1
      UniProtKB/Swiss-Prot
      P06396
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      121201483..121332844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447523.1XP_024303291.1  gelsolin isoform X5

      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    2. XM_024447524.1XP_024303292.1  gelsolin isoform X5

      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    3. XM_011518593.1XP_011516895.1  gelsolin isoform X5

      See identical proteins and their annotated locations for XP_011516895.1

      UniProtKB/Swiss-Prot
      P06396
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    4. XM_011518584.1XP_011516886.1  gelsolin isoform X1

      Conserved Domains (6) summary
      cd11288
      Location:559647
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:184273
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:57169
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:664762
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:293393
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:437537
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    5. XM_017014648.1XP_016870137.1  gelsolin isoform X4

      UniProtKB/Swiss-Prot
      P06396
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    6. XM_024447522.1XP_024303290.1  gelsolin isoform X1

      Conserved Domains (6) summary
      cd11288
      Location:559647
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:184273
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:57169
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:664762
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:293393
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:437537
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    7. XM_011518585.1XP_011516887.1  gelsolin isoform X2

      Conserved Domains (6) summary
      cd11288
      Location:540628
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:165254
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:38150
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:645743
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:274374
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:418518
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    8. XM_017014645.1XP_016870134.1  gelsolin isoform X3

      Conserved Domains (6) summary
      cd11288
      Location:531619
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:156245
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:29141
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:636734
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:265365
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:409509
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    9. XM_005251944.1XP_005252001.1  gelsolin isoform X4

      See identical proteins and their annotated locations for XP_005252001.1

      UniProtKB/Swiss-Prot
      P06396
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    10. XM_011518594.1XP_011516896.1  gelsolin isoform X6

      Conserved Domains (5) summary
      cd11288
      Location:352440
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:457555
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:86186
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:230330
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1266
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    RNA

    1. XR_001746283.2 RNA Sequence

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