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    CD274 CD274 molecule [ Homo sapiens (human) ]

    Gene ID: 29126, updated on 20-Jan-2019

    Summary

    Official Symbol
    CD274provided by HGNC
    Official Full Name
    CD274 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:17635
    See related
    Ensembl:ENSG00000120217 MIM:605402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
    Summary
    This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in appendix (RPKM 6.7), placenta (RPKM 4.5) and 23 other tissues See more
    Orthologs

    Genomic context

    See CD274 in Genome Data Viewer
    Location:
    9p24.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (5450503..5470567)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5450503..5470567)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 31 Neighboring gene relaxin 2 Neighboring gene relaxin 1 Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene ring finger protein 152 pseudogene 1 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene RIC1 homolog, RAB6A GEF complex partner 1 Neighboring gene endoplasmic reticulum metallopeptidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The low mannose-level gp120 induces higher activation of plasmacytoid dendritic cells by upregulation of IFN-alpha, PD-L1, CD40, CCR7, CD80, and CD86 than the high mannose-level gp120 does PubMed
    Tat tat HIV-1 Tat-induced upregulation of PD-L1 on monocyte-derived dendritic cells involves a TNF-alpha-mediated mechanism through the TLR4 pathway PubMed
    tat The N-terminal domain (residues 1-45) of HIV-1 Tat is required for the Tat-induced upregulation of PD-L1 in monocyte-derived dendritic cells PubMed
    tat HIV-1 Tat upregulates the expression of PD-L1 on the surface of dendritic cells and monocyte-derived dendritic cells PubMed
    tat HIV-1 Tat-induced upregulation of B7-H1 protein expression requires activation of the ERK/MAPK signaling pathway in human endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC142294, MGC142296

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell costimulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell costimulation TAS
    Traceable Author Statement
    more info
     
    cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of CD8-positive, alpha-beta T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor superfamily cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-10 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tolerance induction to tumor cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of T cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of activated CD4-positive, alpha-beta T cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cytokine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    toxin transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    programmed cell death 1 ligand 1
    Names
    B7 homolog 1
    CD274 antigen
    PDCD1 ligand 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267706.1NP_001254635.1  programmed cell death 1 ligand 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001254635.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AI826502, AL135786, AL162253, AY291313, DQ836393
      Consensus CDS
      CCDS59118.1
      UniProtKB/Swiss-Prot
      Q9NZQ7
      UniProtKB/TrEMBL
      Q0GN75
      Related
      ENSP00000370985.4, ENST00000381573.8
      Conserved Domains (1) summary
      cl11960
      Location:21106
      Ig; Immunoglobulin domain
    2. NM_001314029.1NP_001300958.1  programmed cell death 1 ligand 1 isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and novel 3' UTR compared to variant 1. It encodes isoform c which is shorter than and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA399416, AL135786, DB160805, DQ836393
      UniProtKB/TrEMBL
      Q0GN75
      Conserved Domains (2) summary
      smart00410
      Location:24130
      IG_like; Immunoglobulin like
      cl11960
      Location:66114
      Ig; Immunoglobulin domain
    3. NM_014143.4NP_054862.1  programmed cell death 1 ligand 1 isoform a precursor

      See identical proteins and their annotated locations for NP_054862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AI826502, AK314567, AL162253
      Consensus CDS
      CCDS6464.1
      UniProtKB/Swiss-Prot
      Q9NZQ7
      Related
      ENSP00000370989.3, ENST00000381577.3
      Conserved Domains (1) summary
      cl11960
      Location:54117
      Ig; Immunoglobulin domain

    RNA

    1. NR_052005.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI826502, AL135786, AL162253, AY714881, DQ836393

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      5450503..5470567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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