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    DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 [ Homo sapiens (human) ]

    Gene ID: 29103, updated on 8-Dec-2018

    Summary

    Official Symbol
    DNAJC15provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C15provided by HGNC
    Primary source
    HGNC:HGNC:20325
    See related
    Ensembl:ENSG00000120675 MIM:615339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCJ; HSD18; DNAJD1
    Expression
    Ubiquitous expression in duodenum (RPKM 13.6), small intestine (RPKM 12.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See DNAJC15 in Genome Data Viewer
    Location:
    13q14.11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (43023226..43109170)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (43597362..43683306)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene epithelial stromal interaction 1 Neighboring gene uncharacterized LOC105370178 Neighboring gene zinc finger DHHC-type containing 4 pseudogene 1 Neighboring gene uncharacterized LOC105370179 Neighboring gene long intergenic non-protein coding RNA 400 Neighboring gene LINC00400 intron CAGE-defined mid-level expression enhancer Neighboring gene molybdenum cofactor synthesis 3 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PAM complex, Tim23 associated import motor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 15
    Names
    DNAJ domain-containing
    DnaJ (Hsp40) homolog, subfamily C, member 15
    DnaJ (Hsp40) homolog, subfamily D, member 1
    cell growth-inhibiting gene 22 protein
    methylation-controlled J protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013238.2NP_037370.2  dnaJ homolog subfamily C member 15

      See identical proteins and their annotated locations for NP_037370.2

      Status: VALIDATED

      Source sequence(s)
      AF126743, AL445217, CA444534
      Consensus CDS
      CCDS9388.1
      UniProtKB/Swiss-Prot
      Q9Y5T4
      Related
      ENSP00000368523.2, ENST00000379221.3
      Conserved Domains (1) summary
      cl02542
      Location:41144
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      43023226..43109170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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