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    ARHGAP35 Rho GTPase activating protein 35 [ Homo sapiens (human) ]

    Gene ID: 2909, updated on 25-Nov-2021

    Summary

    Official Symbol
    ARHGAP35provided by HGNC
    Official Full Name
    Rho GTPase activating protein 35provided by HGNC
    Primary source
    HGNC:HGNC:4591
    See related
    Ensembl:ENSG00000160007 MIM:605277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP
    Summary
    The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 28.9), brain (RPKM 18.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARHGAP35 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46860997..47005077)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47364254..47508334)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small NF90 (ILF3) associated RNA E Neighboring gene adaptor related protein complex 2 subunit sigma 1 Neighboring gene neuronal PAS domain protein 1 Neighboring gene transmembrane protein 160

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env The 3S motif of HIV-1 gp41 activates p190 RhoGAP PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1722, MGC10745

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activating protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axonal fasciculation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in camera-type eye development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to extracellular stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in central nervous system neuron axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment or maintenance of actin cytoskeleton polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mammary gland development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin polymerization or depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 35
    Names
    glucocorticoid receptor DNA-binding factor 1
    glucocorticoid receptor repression factor 1
    rho GAP p190A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047014.2 RefSeqGene

      Range
      5001..149081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004491.5NP_004482.4  rho GTPase-activating protein 35

      See identical proteins and their annotated locations for NP_004482.4

      Status: REVIEWED

      Source sequence(s)
      AB051509, AC008755, AC008895, BE871213, CA429690, CX163309
      Consensus CDS
      CCDS46127.1
      UniProtKB/Swiss-Prot
      Q9NRY4
      Related
      ENSP00000500409.1, ENST00000672722.1
      Conserved Domains (5) summary
      smart00441
      Location:431483
      FF; Contains two conserved F residues
      smart00173
      Location:158250
      RAS; Ras subfamily of RAS small GTPases
      cd04373
      Location:12471431
      RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
      pfam16512
      Location:261340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cd22221
      Location:594765
      pseudoGTPaseD_p190RhoGAP-A; pseudoGTPase domain found in p190RhoGAP-A and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      46860997..47005077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451473.1XP_024307241.1  rho GTPase-activating protein 35 isoform X1

      Conserved Domains (4) summary
      smart00441
      Location:431483
      FF; Contains two conserved F residues
      cl02570
      Location:12471380
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      pfam16512
      Location:261340
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl27030
      Location:158250
      Ras; Ras family

    RNA

    1. XR_002958305.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024342.1: Suppressed sequence

      Description
      NM_024342.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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