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    GRIN1 glutamate ionotropic receptor NMDA type subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2902, updated on 5-Dec-2021

    Summary

    Official Symbol
    GRIN1provided by HGNC
    Official Full Name
    glutamate ionotropic receptor NMDA type subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4584
    See related
    Ensembl:ENSG00000176884 MIM:138249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NR1; MRD8; GluN1; NMDA1; NDHMSD; NDHMSR; NMD-R1; NMDAR1
    Summary
    The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward brain (RPKM 50.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRIN1 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (137139092..137168759)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140033606..140063208)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 1B member 1 Neighboring gene dipeptidyl peptidase 7 Neighboring gene uncharacterized LOC105376328 Neighboring gene microRNA 3621 Neighboring gene leucine rich repeat containing 26 Neighboring gene transmembrane protein 210

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
    env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
    env HIV-1 gp120-induced synapse loss requires sequential activation of CXCR4, IL-1beta receptor, and NMDA receptor PubMed
    env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
    env HIV-1 clade B gp120 significantly downregulates NMDA receptor gene and protein expression and levels of glutamine compared to clade C gp120 PubMed
    env HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects PubMed
    env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit PubMed
    Tat tat The gene expression of GRIN1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    tat Ca(2+) influx through the NMDA receptor is necessary for HIV-1 Tat-induced synapse loss PubMed
    tat HIV-1 Tat-induced dendritic swellings that act in striatal neurons are regulated by NMDA and AMPA receptor-related events PubMed
    tat HIV-1 Tat upregulates the expression of NMDARs for the apoptosis of retinal pigmen epithelium (RPE) cells. Silencing of NMDARs by siRNA abolishes Tat-induced RPE apoptosis PubMed
    tat HIV-1 Tat-induced activation of spermine oxidase (SMO) activity involves NMDAR stimulation in human neuroblastoma PubMed
    tat HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death PubMed
    tat HIV-1 Tat interacts with NMDA receptors in primary neuronal-glial cultures and in hippocampal slice cultures PubMed
    tat Tat treatment causes activation of neuronal nitric oxide synthase (nNOS) through association with NMDA receptors PubMed
    tat HIV-1 Tat treatment induces the formation of complexes involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), and N-methyl-d-aspartic acid (NMDA) receptors at the neuron surface PubMed
    tat HIV-1 Tat-induced NMDA receptor activation is clade dependent. The Cys 30-Cys 31 motif in Tat is critical for the NMDA receptor activation PubMed
    tat HIV-1 Tat upregulates expression of NMDA receptor 1 in mixed cultures of human neurons and astrocytes PubMed
    tat HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to NMDA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to NMDA glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NMDA glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NMDA glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables NMDA glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NMDA glutamate receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables amyloid-beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glutamate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamate-gated calcium ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ligand-gated ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables neurotransmitter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in brain development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion transmembrane import into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in cellular response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in excitatory chemical synaptic transmission NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ionotropic glutamate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of calcium ion transport into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of reactive oxygen species biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in propylene metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic plasticity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to glycine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in visual learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NMDA selective glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NMDA selective glutamate receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in excitatory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic cleft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in terminal bouton ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    glutamate receptor ionotropic, NMDA 1
    Names
    N-methyl-D-aspartate receptor channel, subunit zeta-1
    N-methyl-D-aspartate receptor subunit NR1
    glutamate [NMDA] receptor subunit zeta-1
    glutamate receptor, ionotropic, N-methyl D-aspartate 1
    putative NMDtranscript(altAcc_e2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011507.1 RefSeqGene

      Range
      4998..34600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000832.7NP_000823.4  glutamate receptor ionotropic, NMDA 1 isoform GluN1-4a precursor

      See identical proteins and their annotated locations for NP_000823.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-4a, also known as NR1-1) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant GluN1-1a. The resulting protein (isoform GluN1-4a, also known as isoform NR1-1) is shorter and has a different C-terminus, compared to isoform GluN1-1a.
      Source sequence(s)
      AL929554, L13266
      Consensus CDS
      CCDS43910.1
      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360614.4, ENST00000371559.8
      Conserved Domains (3) summary
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06379
      Location:25383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    2. NM_001185090.2NP_001172019.1  glutamate receptor ionotropic, NMDA 1 isoform GluN1-3b precursor

      See identical proteins and their annotated locations for NP_001172019.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-3b, also known as NR1-4) contains an alternate coding segment and uses a different splice site in the 3' coding region, compared to variant GluN1-1a. The resulting protein (isoform GluN1-3b, also known as isoform NR1-4) is longer and has a distinct C-terminus when it is compared to isoform GluN1-1a. This variant has also been named isoform 4b or NMDAR1-4b.
      Source sequence(s)
      AB208999, AF015731, AL929554, BU728516, L13268
      Consensus CDS
      CCDS55354.1
      UniProtKB/Swiss-Prot
      Q05586
      UniProtKB/TrEMBL
      Q59GW0
      Related
      ENSP00000360608.3, ENST00000371553.7
      Conserved Domains (3) summary
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06379
      Location:25404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    3. NM_001185091.2NP_001172020.1  glutamate receptor ionotropic, NMDA 1 isoform GluN1-5b precursor

      See identical proteins and their annotated locations for NP_001172020.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-5b, also known as 5) contains an alternate coding segment, lacks a different alternate coding segment, and uses a different splice site in the 3' coding region, compared to variant GluN1-1a. The resulting protein (isoform GluN1-5b, also known as isoform 5) is shorter and has a distinct C-terminus when it is compared to isoform GluN1-1a. This variant has also been named isoform 3b or NMDAR1-3b.
      Source sequence(s)
      AB208999, AF015730, AL929554, BU728516, L13268
      Consensus CDS
      CCDS55355.1
      UniProtKB/Swiss-Prot
      Q05586
      UniProtKB/TrEMBL
      Q59GW0
      Related
      ENSP00000360615.3, ENST00000371560.4
      Conserved Domains (3) summary
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06379
      Location:25404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    4. NM_007327.4NP_015566.1  glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a precursor

      See identical proteins and their annotated locations for NP_015566.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-1a, also known as NR1-3) represents the longest transcript and encodes protein isoform GluN1-1a (also known as isoform NR1-3).
      Source sequence(s)
      AL929554, D13515
      Consensus CDS
      CCDS7031.1
      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360616.3, ENST00000371561.8
      Conserved Domains (3) summary
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06379
      Location:25383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    5. NM_021569.4NP_067544.1  glutamate receptor ionotropic, NMDA 1 isoform GluN1-2a precursor

      See identical proteins and their annotated locations for NP_067544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (GluN1-2a, also known as NR1-2) lacks an alternate in-frame exon in the 3' coding region, compared to variant GluN1-1a, resulting in a shorter protein (isoform GluN1-2a, also known as isoform NR1-2), compared to isoform GluN1-1a.
      Source sequence(s)
      AL929554, D13515, L13267
      Consensus CDS
      CCDS7032.1
      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360605.4, ENST00000371550.8
      Conserved Domains (3) summary
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06379
      Location:25383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      137139092..137168759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266073.4XP_005266130.1  glutamate receptor ionotropic, NMDA 1 isoform X1

      See identical proteins and their annotated locations for XP_005266130.1

      UniProtKB/Swiss-Prot
      Q05586
      Related
      ENSP00000360601.4, ENST00000371546.8
      Conserved Domains (3) summary
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06379
      Location:25404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    2. XM_005266072.3XP_005266129.1  glutamate receptor ionotropic, NMDA 1 isoform X3

      See identical proteins and their annotated locations for XP_005266129.1

      UniProtKB/TrEMBL
      Q5VSF9
      Related
      ENSP00000360610.4, ENST00000371555.8
      Conserved Domains (3) summary
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06379
      Location:25404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    3. XM_011518583.2XP_011516885.1  glutamate receptor ionotropic, NMDA 1 isoform X4

      See identical proteins and their annotated locations for XP_011516885.1

      Related
      ENST00000471122.5
      Conserved Domains (3) summary
      cd13719
      Location:416820
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06379
      Location:25404
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:856884
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
    4. XM_005266071.3XP_005266128.1  glutamate receptor ionotropic, NMDA 1 isoform X2

      See identical proteins and their annotated locations for XP_005266128.1

      UniProtKB/Swiss-Prot
      Q05586
      Conserved Domains (3) summary
      cd13719
      Location:395799
      PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06379
      Location:25383
      PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
      pfam10562
      Location:835863
      CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
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