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    ANK3 ankyrin 3 [ Homo sapiens (human) ]

    Gene ID: 288, updated on 17-Jun-2019

    Summary

    Official Symbol
    ANK3provided by HGNC
    Official Full Name
    ankyrin 3provided by HGNC
    Primary source
    HGNC:HGNC:494
    See related
    Ensembl:ENSG00000151150 MIM:600465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRT37; ANKYRIN-G
    Summary
    Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
    Expression
    Broad expression in kidney (RPKM 10.0), brain (RPKM 9.0) and 23 other tissues See more
    Orthologs

    Genomic context

    See ANK3 in Genome Data Viewer
    Location:
    10q21.2
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (60026298..60733528, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (61786056..62493284, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 6 Neighboring gene long intergenic non-protein coding RNA 1553 Neighboring gene Sharpr-MPRA regulatory region 4517 Neighboring gene uncharacterized LOC107987153 Neighboring gene uncharacterized LOC107984292 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 1 Neighboring gene ANK3 divergent transcript Neighboring gene cyclin dependent kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Mental retardation, autosomal recessive 37
    MedGen: C3809672 OMIM: 615493 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.
    NHGRI GWA Catalog
    Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
    NHGRI GWA Catalog
    Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.
    NHGRI GWA Catalog
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    NHGRI GWA Catalog
    Genome-wide association study identifies five new schizophrenia loci.
    NHGRI GWA Catalog
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    NHGRI GWA Catalog
    Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
    NHGRI GWA Catalog
    Genome-wide association study reveals two new risk loci for bipolar disorder.
    NHGRI GWA Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    NHGRI GWA Catalog
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of ankyrin 3 (ANK3, ankyrin G) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
      COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • Interaction between L1 and Ankyrins, organism-specific biosystem (from REACTOME)
      Interaction between L1 and Ankyrins, organism-specific biosystemAnkyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by t...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ45464

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeletal protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ion channel binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ion channel binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spectrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    structural constituent of cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to magnesium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeletal anchoring at plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    magnesium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    maintenance of protein location in plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuromuscular junction development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell communication by electrical coupling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of homotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of membrane depolarization during cardiac muscle cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of sodium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein localization to axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon initial segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon initial segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon initial segment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    costamere TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    intercalated disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuromuscular junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    node of Ranvier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spectrin-associated cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ankyrin-3
    Names
    ankyrin 3, node of Ranvier (ankyrin G)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029917.1 RefSeqGene

      Range
      5001..712229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001149.3NP_001140.2  ankyrin-3 isoform 2

      See identical proteins and their annotated locations for NP_001140.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 5' UTR and coding sequence compared to variant 1, resulting in an isoform (2) which is considerably shorter and different compared to isoform 1.
      Source sequence(s)
      AC023904, AK092527, AL136710, AL592430, AW451432
      Consensus CDS
      CCDS7259.1
      UniProtKB/Swiss-Prot
      Q12955
      UniProtKB/TrEMBL
      Q8NAK2
      Related
      ENSP00000347436.2, ENST00000355288.6
      Conserved Domains (2) summary
      smart00218
      Location:116220
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:609692
      Death_ank3; Death domain of Ankyrin-3
    2. NM_001204403.2NP_001191332.1  ankyrin-3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and is considerably shorter than isoform 1.
      Source sequence(s)
      AC022390, AC023904, AL359377, AW451432, BP245303, BX537917
      Consensus CDS
      CCDS55712.1
      UniProtKB/Swiss-Prot
      Q12955
      Related
      ENSP00000362933.2, ENST00000373827.6
      Conserved Domains (7) summary
      smart00218
      Location:9761080
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14691552
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:62187
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:72158
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:625678
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:743797
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:690721
      ANK; ANK repeat [structural motif]
    3. NM_001204404.2NP_001191333.1  ankyrin-3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 4) has a distinct N-terminus and is considerably shorter than isoform 1.
      Source sequence(s)
      AC023904, AK295661, AL359377, AL391707, AL592430, AW451432
      Consensus CDS
      CCDS55711.1
      UniProtKB/Swiss-Prot
      Q12955
      Related
      ENSP00000425236.1, ENST00000503366.5
      Conserved Domains (7) summary
      smart00218
      Location:9831087
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14761559
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:51176
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:61147
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:614667
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:732786
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:679710
      ANK; ANK repeat [structural motif]
    4. NM_001320874.2NP_001307803.1  ankyrin-3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains one and lacks two alternate in-frame exons in its 3' coding region compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC023904, AL359377, AL592430, AW451432, BP202757, BP310397, DB237893
      Conserved Domains (7) summary
      smart00218
      Location:9821086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14751558
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:78164
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:631684
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:749803
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
    5. NM_020987.5NP_066267.2  ankyrin-3 isoform 1

      See identical proteins and their annotated locations for NP_066267.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC023904, AL359377, AL592430, AW451432, BP202757, U13616
      Consensus CDS
      CCDS7258.1
      UniProtKB/Swiss-Prot
      Q12955
      Related
      ENSP00000280772.1, ENST00000280772.7
      Conserved Domains (7) summary
      smart00218
      Location:9821086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40884171
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:78164
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:631684
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:749803
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      60026298..60733528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447958.1XP_024303726.1  ankyrin-3 isoform X12

      Conserved Domains (6) summary
      smart00218
      Location:9651069
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40734156
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:51176
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:679710
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:746798
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:13761755
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    2. XM_017016114.1XP_016871603.1  ankyrin-3 isoform X6

    3. XM_024447957.1XP_024303725.1  ankyrin-3 isoform X11

      Conserved Domains (6) summary
      smart00218
      Location:9711075
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40794162
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:663694
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:567618
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:13821761
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    4. XM_024447960.1XP_024303728.1  ankyrin-3 isoform X14

      Conserved Domains (6) summary
      smart00218
      Location:9611065
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40694152
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:13721751
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    5. XM_017016134.1XP_016871623.1  ankyrin-3 isoform X42

    6. XM_017016127.1XP_016871616.1  ankyrin-3 isoform X32

    7. XM_017016141.1XP_016871630.1  ankyrin-3 isoform X46

    8. XM_017016126.1XP_016871615.1  ankyrin-3 isoform X31

    9. XM_024447961.1XP_024303729.1  ankyrin-3 isoform X15

      Conserved Domains (6) summary
      smart00218
      Location:9601064
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40684151
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:13711750
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    10. XM_024447959.1XP_024303727.1  ankyrin-3 isoform X13

      Conserved Domains (6) summary
      smart00218
      Location:9651069
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40734156
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:13761755
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    11. XM_024447955.1XP_024303723.1  ankyrin-3 isoform X8

      Conserved Domains (6) summary
      smart00218
      Location:9831087
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40914174
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:13941773
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    12. XM_017016131.1XP_016871620.1  ankyrin-3 isoform X40

    13. XM_017016132.1XP_016871621.1  ankyrin-3 isoform X41

    14. XM_017016130.1XP_016871619.1  ankyrin-3 isoform X39

    15. XM_017016122.1XP_016871611.1  ankyrin-3 isoform X26

    16. XM_024447956.1XP_024303724.1  ankyrin-3 isoform X9

      Conserved Domains (6) summary
      smart00218
      Location:9821086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40904173
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:13931772
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    17. XM_024447954.1XP_024303722.1  ankyrin-3 isoform X7

      Conserved Domains (6) summary
      smart00218
      Location:9861090
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:40944177
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:13971776
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    18. XM_017016125.1XP_016871614.1  ankyrin-3 isoform X30

    19. XM_024447953.1XP_024303721.1  ankyrin-3 isoform X5

      Conserved Domains (6) summary
      smart00218
      Location:9951099
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:41034186
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:14061785
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    20. XM_005269715.3XP_005269772.1  ankyrin-3 isoform X38

      Conserved Domains (7) summary
      smart00218
      Location:10001104
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14931576
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:78164
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:631684
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:749803
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
    21. XM_017016111.1XP_016871600.1  ankyrin-3 isoform X2

    22. XM_017016112.1XP_016871601.1  ankyrin-3 isoform X3

    23. XM_024447964.1XP_024303732.1  ankyrin-3 isoform X33

      Conserved Domains (5) summary
      smart00218
      Location:10041108
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14851568
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
    24. XM_017016138.1XP_016871627.1  ankyrin-3 isoform X45

    25. XM_017016137.1XP_016871626.1  ankyrin-3 isoform X44

    26. XM_017016129.1XP_016871618.1  ankyrin-3 isoform X36

    27. XM_017016128.1XP_016871617.1  ankyrin-3 isoform X35

    28. XM_017016124.1XP_016871613.1  ankyrin-3 isoform X29

    29. XM_017016121.1XP_016871610.1  ankyrin-3 isoform X22

    30. XM_024447962.1XP_024303730.1  ankyrin-3 isoform X18

      Conserved Domains (6) summary
      smart00218
      Location:10041108
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:36563739
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:14151785
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    31. XM_017016113.1XP_016871602.1  ankyrin-3 isoform X4

    32. XM_024447965.1XP_024303733.1  ankyrin-3 isoform X37

      Conserved Domains (5) summary
      smart00218
      Location:10041108
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:14941577
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
    33. XM_017016136.1XP_016871625.1  ankyrin-3 isoform X43

    34. XM_006717802.3XP_006717865.1  ankyrin-3 isoform X34

      Conserved Domains (7) summary
      smart00218
      Location:10041108
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:15061589
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:78164
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:631684
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:749803
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
    35. XM_017016123.1XP_016871612.1  ankyrin-3 isoform X28

    36. XM_011539709.2XP_011538011.1  ankyrin-3 isoform X27

      Conserved Domains (7) summary
      smart00218
      Location:10041108
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:23672450
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:78164
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:631684
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:749803
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
    37. XM_006717796.3XP_006717859.1  ankyrin-3 isoform X25

      Conserved Domains (7) summary
      smart00218
      Location:10041108
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:23672450
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:78164
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:631684
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:749803
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
    38. XM_011539708.2XP_011538010.1  ankyrin-3 isoform X24

      Conserved Domains (7) summary
      smart00218
      Location:10041108
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:23672450
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:78164
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:631684
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:749803
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
    39. XM_024447963.1XP_024303731.1  ankyrin-3 isoform X23

      Conserved Domains (6) summary
      smart00218
      Location:10041108
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08803
      Location:23672450
      Death_ank3; Death domain of Ankyrin-3
      cd00204
      Location:68193
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:696727
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:763815
      Ank_4; Ankyrin repeats (many copies)
      cl25496
      Location:14151794
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    40. XM_017016120.1XP_016871609.1  ankyrin-3 isoform X21

    41. XM_017016119.1XP_016871608.1  ankyrin-3 isoform X20

    42. XM_017016118.1XP_016871607.1  ankyrin-3 isoform X19

    43. XM_017016117.1XP_016871606.1  ankyrin-3 isoform X17

    44. XM_017016116.1XP_016871605.1  ankyrin-3 isoform X16

    45. XM_017016110.1XP_016871599.1  ankyrin-3 isoform X1

    46. XM_017016115.1XP_016871604.1  ankyrin-3 isoform X10

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