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    GRK6 G protein-coupled receptor kinase 6 [ Homo sapiens (human) ]

    Gene ID: 2870, updated on 2-May-2024

    Summary

    Official Symbol
    GRK6provided by HGNC
    Official Full Name
    G protein-coupled receptor kinase 6provided by HGNC
    Primary source
    HGNC:HGNC:4545
    See related
    Ensembl:ENSG00000198055 MIM:600869; AllianceGenome:HGNC:4545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPRK6
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 27.2), lymph node (RPKM 19.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRK6 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (177425523..177442891)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177968774..177986142)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176853677..176869892)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176828971-176829828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176830685-176831542 Neighboring gene profilin 3 Neighboring gene coagulation factor XII Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176853351-176853890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176867639-176868335 Neighboring gene PRR7 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176874472-176875100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176876138-176876638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176876639-176877139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16688 Neighboring gene proline rich 7, synaptic Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176881361-176882061 Neighboring gene Sharpr-MPRA regulatory region 1974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176884168-176884868 Neighboring gene drebrin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176894101-176894646 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176895193-176895738 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176895739-176896284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176897377-176897922 Neighboring gene hESC enhancers GRCh37_chr5:176899493-176899996 and GRCh37_chr5:176899997-176900498

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
    EBI GWAS Catalog
    New loci associated with kidney function and chronic kidney disease.
    EBI GWAS Catalog
    Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32135

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-adrenergic receptor kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-adrenergic receptor kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables beta-adrenergic receptor kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    G protein-coupled receptor kinase 6
    NP_001004105.1
    NP_001004106.1
    NP_001351093.1
    NP_002073.2
    XP_006714921.1
    XP_006714922.1
    XP_011532840.1
    XP_047273082.1
    XP_054208434.1
    XP_054208435.1
    XP_054208436.1
    XP_054208437.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031981.1 RefSeqGene

      Range
      4991..21206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004105.3NP_001004105.1  G protein-coupled receptor kinase 6 isoform C

      See identical proteins and their annotated locations for NP_001004105.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 2, resulting in a shorter isoform (C) with a distinct C-terminus compared to isoform B.
      Source sequence(s)
      AC145098, AF040752, BC009277, BI258860
      Consensus CDS
      CCDS43406.1
      UniProtKB/TrEMBL
      Q96AD6
      Related
      ENSP00000348230.5, ENST00000355958.9
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_001004106.3NP_001004106.1  G protein-coupled receptor kinase 6 isoform A

      See identical proteins and their annotated locations for NP_001004106.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate acceptor splice site in the last exon, compared to variant 2, resulting in a shorter isoform (A) compared to isoform B.
      Source sequence(s)
      AC145098, BC009277, BI258860
      Consensus CDS
      CCDS34303.1
      UniProtKB/Swiss-Prot
      O60541, P43250, Q13652
      UniProtKB/TrEMBL
      F8W9W2
      Related
      ENSP00000347655.5, ENST00000355472.10
      Conserved Domains (2) summary
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_001364164.2NP_001351093.1  G protein-coupled receptor kinase 6 isoform D

      Status: REVIEWED

      Source sequence(s)
      AC145098
      Conserved Domains (1) summary
      cl21453
      Location:1259
      PKc_like; Protein Kinases, catalytic domain
    4. NM_002082.4NP_002073.2  G protein-coupled receptor kinase 6 isoform B

      See identical proteins and their annotated locations for NP_002073.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (B).
      Source sequence(s)
      AC145098, AF040751, BC009277, BI258860
      UniProtKB/TrEMBL
      Q96AD6
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      177425523..177442891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417126.1XP_047273082.1  G protein-coupled receptor kinase 6 isoform X3

    2. XM_006714859.3XP_006714922.1  G protein-coupled receptor kinase 6 isoform X2

      UniProtKB/TrEMBL
      Q96AD6
      Conserved Domains (3) summary
      smart00220
      Location:154416
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:153437
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:3147
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. XM_006714858.4XP_006714921.1  G protein-coupled receptor kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_006714921.1

      UniProtKB/TrEMBL
      B3KPS5, Q96AD6
      Conserved Domains (3) summary
      smart00220
      Location:156418
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:155439
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:20149
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    4. XM_011534538.2XP_011532840.1  G protein-coupled receptor kinase 6 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:1183
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1204
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      177968774..177986142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352461.1XP_054208436.1  G protein-coupled receptor kinase 6 isoform X3

    2. XM_054352460.1XP_054208435.1  G protein-coupled receptor kinase 6 isoform X2

    3. XM_054352459.1XP_054208434.1  G protein-coupled receptor kinase 6 isoform X1

      UniProtKB/TrEMBL
      B3KPS5
    4. XM_054352462.1XP_054208437.1  G protein-coupled receptor kinase 6 isoform X4