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    GRK5 G protein-coupled receptor kinase 5 [ Homo sapiens (human) ]

    Gene ID: 2869, updated on 8-Jul-2021

    Summary

    Official Symbol
    GRK5provided by HGNC
    Official Full Name
    G protein-coupled receptor kinase 5provided by HGNC
    Primary source
    HGNC:HGNC:4544
    See related
    Ensembl:ENSG00000198873 MIM:600870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPRK5; FP2025
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 30.9), spleen (RPKM 17.1) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GRK5 in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (119207571..119459745)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120967083..121219257)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene sideroflexin 4 Neighboring gene peroxiredoxin 3 Neighboring gene RNA, 7SL, cytoplasmic 749, pseudogene Neighboring gene GRK5 intronic transcript 1 Neighboring gene Sharpr-MPRA regulatory region 9266 Neighboring gene uncharacterized LOC105378511 Neighboring gene microRNA 4681 Neighboring gene regulator of G protein signaling 10 Neighboring gene uncharacterized LOC105378512 Neighboring gene TIA1 cytotoxic granule associated RNA binding protein like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
    GeneReviews: Not available
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ39780

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-adrenergic receptor kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables beta-adrenergic receptor kinase activity TAS
    Traceable Author Statement
    more info
     
    enables phospholipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    G protein-coupled receptor kinase 5
    Names
    g protein-coupled receptor kinase GRK5
    NP_005299.1
    XP_005269764.1
    XP_005269765.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005308.3NP_005299.1  G protein-coupled receptor kinase 5

      See identical proteins and their annotated locations for NP_005299.1

      Status: REVIEWED

      Source sequence(s)
      AL355273, AL355861, BC018116, BC064506, BQ184611, CN290123, L15388
      Consensus CDS
      CCDS7612.1
      UniProtKB/Swiss-Prot
      P34947
      Related
      ENSP00000376609.2, ENST00000392870.3
      Conserved Domains (3) summary
      cd08752
      Location:53175
      RGS_GRK5; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05632
      Location:183495
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      119207571..119459745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269707.2XP_005269764.1  G protein-coupled receptor kinase 5 isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:186418
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:53175
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:183465
      PKc_like; Protein Kinases, catalytic domain
    2. XM_005269708.1XP_005269765.1  G protein-coupled receptor kinase 5 isoform X2

      Conserved Domains (3) summary
      cd08752
      Location:21143
      RGS_GRK5; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 5 (GRK5)
      smart00220
      Location:154416
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05632
      Location:151463
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
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