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    GRK4 G protein-coupled receptor kinase 4 [ Homo sapiens (human) ]

    Gene ID: 2868, updated on 1-Mar-2024

    Summary

    Official Symbol
    GRK4provided by HGNC
    Official Full Name
    G protein-coupled receptor kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:4543
    See related
    Ensembl:ENSG00000125388 MIM:137026; AllianceGenome:HGNC:4543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IT11; GPRK4; GRK4a; GPRK2L
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
    Expression
    Biased expression in testis (RPKM 14.6) and brain (RPKM 0.7) See more
    Orthologs
    NEW
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    Genomic context

    See GRK4 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (2963571..3040760)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (2962247..3039448)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2965298..3042487)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2935265-2936132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15194 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:2937390-2938589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21204 Neighboring gene NOP14 antisense RNA 1 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:2948362-2949561 Neighboring gene NOP14 nucleolar protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:2964791-2965324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2965325-2965858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15196 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:3011160-3012359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3022951-3023451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21213 Neighboring gene RNA, U6 small nuclear 204, pseudogene Neighboring gene HTT antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15199

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables rhodopsin kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of rhodopsin mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in photoreceptor disc membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    G protein-coupled receptor kinase 4
    Names
    G protein-coupled receptor kinase 2-like
    NP_001004056.1
    NP_001004057.1
    NP_001337102.1
    NP_005298.2
    NP_892027.2
    XP_005248019.1
    XP_011511749.1
    XP_011511750.1
    XP_011511751.1
    XP_011511752.1
    XP_011511753.1
    XP_011511754.1
    XP_011511755.1
    XP_011511756.1
    XP_011511757.1
    XP_011511758.1
    XP_011511759.1
    XP_016863541.1
    XP_016863542.1
    XP_016863543.1
    XP_016863544.1
    XP_016863545.1
    XP_047306080.1
    XP_047306081.1
    XP_047306082.1
    XP_047306083.1
    XP_047306084.1
    XP_054205768.1
    XP_054205769.1
    XP_054205770.1
    XP_054205771.1
    XP_054205772.1
    XP_054205773.1
    XP_054205774.1
    XP_054205775.1
    XP_054205776.1
    XP_054205777.1
    XP_054205778.1
    XP_054205779.1
    XP_054205780.1
    XP_054205781.1
    XP_054205782.1
    XP_054205783.1
    XP_054205784.1
    XP_054205785.1
    XP_054205786.1
    XP_054205787.1
    XP_054205788.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029102.1 RefSeqGene

      Range
      4956..82145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004056.2NP_001004056.1  G protein-coupled receptor kinase 4 isoform beta

      See identical proteins and their annotated locations for NP_001004056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (beta) has the same N- and C-termini but is shorter compared to isoform alpha.
      Source sequence(s)
      AL390065, BC027597, BI465220, BM725978, U33054
      Consensus CDS
      CCDS47002.1
      UniProtKB/TrEMBL
      A8K8M5
      Related
      ENSP00000264764.8, ENST00000345167.10
      Conserved Domains (3) summary
      cd05631
      Location:154438
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:155417
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:20152
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_001004057.2NP_001004057.1  G protein-coupled receptor kinase 4 isoform gamma

      See identical proteins and their annotated locations for NP_001004057.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (gamma) has the same N- and C-termini but is shorter compared to isoform alpha.
      Source sequence(s)
      AL390065, BC027597, BI465220, BM725978
      Consensus CDS
      CCDS33947.1
      UniProtKB/TrEMBL
      A8K8M5
      Related
      ENSP00000427445.1, ENST00000504933.1
      Conserved Domains (3) summary
      cd05631
      Location:186470
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:187449
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_001350173.2NP_001337102.1  G protein-coupled receptor kinase 4 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 5, which has a shorter and distinct N-terminus, compared to isoform alpha.
      Source sequence(s)
      AK223581, AK292390, AL390065, BI792406, N23898, X97881
      Conserved Domains (1) summary
      cl21453
      Location:5276
      PKc_like; Protein Kinases, catalytic domain
    4. NM_005307.3NP_005298.2  G protein-coupled receptor kinase 4 isoform delta

      See identical proteins and their annotated locations for NP_005298.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (delta) has the same N- and C-termini but is shorter compared to isoform alpha.
      Source sequence(s)
      AK223581, AL390065, X97879
      Consensus CDS
      CCDS68656.1
      UniProtKB/TrEMBL
      A8K8M5
      Related
      ENSP00000381128.4, ENST00000398051.8
      Conserved Domains (3) summary
      cd05631
      Location:154438
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:155417
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:20152
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    5. NM_182982.3NP_892027.2  G protein-coupled receptor kinase 4 isoform alpha

      See identical proteins and their annotated locations for NP_892027.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha).
      Source sequence(s)
      AL390065, BC027597, BI465220, BM725978, U33054
      Consensus CDS
      CCDS33946.1
      UniProtKB/Swiss-Prot
      O00641, O00642, P32298, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316, Q17RH6, Q53EQ8
      UniProtKB/TrEMBL
      A8K8M5
      Related
      ENSP00000381129.4, ENST00000398052.9
      Conserved Domains (3) summary
      cd05631
      Location:186470
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:187449
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      2963571..3040760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513447.3XP_011511749.1  G protein-coupled receptor kinase 4 isoform X1

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      cd05631
      Location:186509
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:187488
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. XM_011513450.3XP_011511752.1  G protein-coupled receptor kinase 4 isoform X6

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      cd05631
      Location:186509
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:187488
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. XM_011513453.3XP_011511755.1  G protein-coupled receptor kinase 4 isoform X10

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      smart00220
      Location:187488
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186508
      PKc_like; Protein Kinases, catalytic domain
    4. XM_011513451.3XP_011511753.1  G protein-coupled receptor kinase 4 isoform X7

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      smart00220
      Location:187462
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186470
      PKc_like; Protein Kinases, catalytic domain
    5. XM_011513454.3XP_011511756.1  G protein-coupled receptor kinase 4 isoform X9

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (2) summary
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186470
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011513455.3XP_011511757.1  G protein-coupled receptor kinase 4 isoform X12

      Conserved Domains (3) summary
      smart00220
      Location:187471
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186472
      PKc_like; Protein Kinases, catalytic domain
    7. XM_017008053.2XP_016863542.1  G protein-coupled receptor kinase 4 isoform X4

      UniProtKB/TrEMBL
      A8K8M5
    8. XM_011513456.3XP_011511758.1  G protein-coupled receptor kinase 4 isoform X15

      Conserved Domains (2) summary
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186363
      PKc_like; Protein Kinases, catalytic domain
    9. XM_017008054.2XP_016863543.1  G protein-coupled receptor kinase 4 isoform X11

      UniProtKB/TrEMBL
      A8K8M5
    10. XM_017008056.2XP_016863545.1  G protein-coupled receptor kinase 4 isoform X14

    11. XM_017008052.2XP_016863541.1  G protein-coupled receptor kinase 4 isoform X3

      UniProtKB/TrEMBL
      A8K8M5
    12. XM_011513449.3XP_011511751.1  G protein-coupled receptor kinase 4 isoform X5

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (3) summary
      cd05631
      Location:154477
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      smart00220
      Location:155456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:20152
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    13. XM_017008055.2XP_016863544.1  G protein-coupled receptor kinase 4 isoform X13

    14. XM_005247962.4XP_005248019.1  G protein-coupled receptor kinase 4 isoform X17

      See identical proteins and their annotated locations for XP_005248019.1

      Conserved Domains (2) summary
      smart00220
      Location:20238
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1259
      PKc_like; Protein Kinases, catalytic domain
    15. XM_011513452.3XP_011511754.1  G protein-coupled receptor kinase 4 isoform X8

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (2) summary
      cd08750
      Location:52184
      RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
      cl21453
      Location:186470
      PKc_like; Protein Kinases, catalytic domain
    16. XM_011513448.3XP_011511750.1  G protein-coupled receptor kinase 4 isoform X2

      UniProtKB/TrEMBL
      A8K8M5
      Conserved Domains (2) summary
      cd05631
      Location:186509
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cd08750
      Location:52184
      RGS_GRK4; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 4 (GRK4)
    17. XM_047450128.1XP_047306084.1  G protein-coupled receptor kinase 4 isoform X19

    18. XM_047450127.1XP_047306083.1  G protein-coupled receptor kinase 4 isoform X19

    19. XM_011513457.3XP_011511759.1  G protein-coupled receptor kinase 4 isoform X18

      Conserved Domains (2) summary
      cl02565
      Location:52184
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:186286
      PKc_like; Protein Kinases, catalytic domain
    20. XM_047450125.1XP_047306081.1  G protein-coupled receptor kinase 4 isoform X17

    21. XM_047450126.1XP_047306082.1  G protein-coupled receptor kinase 4 isoform X17

    22. XM_047450124.1XP_047306080.1  G protein-coupled receptor kinase 4 isoform X16

    RNA

    1. XR_924941.3 RNA Sequence

    2. XR_001741210.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      2962247..3039448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349793.1XP_054205768.1  G protein-coupled receptor kinase 4 isoform X1

      UniProtKB/TrEMBL
      A8K8M5
    2. XM_054349798.1XP_054205773.1  G protein-coupled receptor kinase 4 isoform X6

      UniProtKB/TrEMBL
      A8K8M5
    3. XM_054349802.1XP_054205777.1  G protein-coupled receptor kinase 4 isoform X10

      UniProtKB/TrEMBL
      A8K8M5
    4. XM_054349799.1XP_054205774.1  G protein-coupled receptor kinase 4 isoform X7

      UniProtKB/TrEMBL
      A8K8M5
    5. XM_054349801.1XP_054205776.1  G protein-coupled receptor kinase 4 isoform X9

      UniProtKB/TrEMBL
      A8K8M5
    6. XM_054349804.1XP_054205779.1  G protein-coupled receptor kinase 4 isoform X12

    7. XM_054349796.1XP_054205771.1  G protein-coupled receptor kinase 4 isoform X4

      UniProtKB/TrEMBL
      A8K8M5
    8. XM_054349807.1XP_054205782.1  G protein-coupled receptor kinase 4 isoform X15

    9. XM_054349803.1XP_054205778.1  G protein-coupled receptor kinase 4 isoform X11

      UniProtKB/TrEMBL
      A8K8M5
    10. XM_054349806.1XP_054205781.1  G protein-coupled receptor kinase 4 isoform X14

    11. XM_054349795.1XP_054205770.1  G protein-coupled receptor kinase 4 isoform X3

      UniProtKB/TrEMBL
      A8K8M5
    12. XM_054349797.1XP_054205772.1  G protein-coupled receptor kinase 4 isoform X5

      UniProtKB/TrEMBL
      A8K8M5
    13. XM_054349805.1XP_054205780.1  G protein-coupled receptor kinase 4 isoform X13

    14. XM_054349810.1XP_054205785.1  G protein-coupled receptor kinase 4 isoform X17

    15. XM_054349800.1XP_054205775.1  G protein-coupled receptor kinase 4 isoform X8

      UniProtKB/TrEMBL
      A8K8M5
    16. XM_054349794.1XP_054205769.1  G protein-coupled receptor kinase 4 isoform X2

      UniProtKB/TrEMBL
      A8K8M5
    17. XM_054349813.1XP_054205788.1  G protein-coupled receptor kinase 4 isoform X19

    18. XM_054349812.1XP_054205787.1  G protein-coupled receptor kinase 4 isoform X18

    19. XM_054349809.1XP_054205784.1  G protein-coupled receptor kinase 4 isoform X17

    20. XM_054349811.1XP_054205786.1  G protein-coupled receptor kinase 4 isoform X17

    21. XM_054349808.1XP_054205783.1  G protein-coupled receptor kinase 4 isoform X16

    RNA

    1. XR_008486968.1 RNA Sequence

    2. XR_008486969.1 RNA Sequence