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    MLNR motilin receptor [ Homo sapiens (human) ]

    Gene ID: 2862, updated on 24-Nov-2020

    Summary

    Official Symbol
    MLNRprovided by HGNC
    Official Full Name
    motilin receptorprovided by HGNC
    Primary source
    HGNC:HGNC:4495
    See related
    Ensembl:ENSG00000102539 MIM:602885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR38; MTLR1
    Summary
    Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See MLNR in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20201120 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (49220338..49222377)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49794474..49796513)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 3A Neighboring gene cytochrome c oxidase subunit 7C pseudogene 1 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 1 pseudogene 1 Neighboring gene uncharacterized LOC105370203 Neighboring gene THAP domain containing 12 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    motilin receptor
    Names
    G protein-coupled receptor 38

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029790.1 RefSeqGene

      Range
      5001..7040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001507.1NP_001498.1  motilin receptor

      See identical proteins and their annotated locations for NP_001498.1

      Status: REVIEWED

      Source sequence(s)
      AY603964
      Consensus CDS
      CCDS9414.1
      UniProtKB/Swiss-Prot
      O43193
      Related
      ENSP00000218721.1, ENST00000218721.1
      Conserved Domains (1) summary
      pfam00001
      Location:55355
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      49220338..49222377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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