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    KCNRG potassium channel regulator [ Homo sapiens (human) ]

    Gene ID: 283518, updated on 10-Dec-2019

    Summary

    Official Symbol
    KCNRGprovided by HGNC
    Official Full Name
    potassium channel regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:18893
    See related
    Ensembl:ENSG00000198553 MIM:607947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DLTET
    Summary
    This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
    Expression
    Broad expression in testis (RPKM 38.4), bone marrow (RPKM 16.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See KCNRG in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (50015444..50020922)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50589390..50595058)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene SPRY domain containing 7 Neighboring gene deleted in lymphocytic leukemia 2 Neighboring gene microRNA 3613 Neighboring gene tripartite motif containing 13 Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    potassium channel regulatory protein
    Names
    putative potassium channel regulatory protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173605.2NP_775876.1  potassium channel regulatory protein isoform 1

      See identical proteins and their annotated locations for NP_775876.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the shorter transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AY169388
      Consensus CDS
      CCDS9424.1
      UniProtKB/Swiss-Prot
      Q8N5I3
      Related
      ENSP00000324191.1, ENST00000312942.2
      Conserved Domains (1) summary
      cl02518
      Location:794
      BTB; BTB/POZ domain
    2. NM_199464.3NP_955751.1  potassium channel regulatory protein isoform 2

      See identical proteins and their annotated locations for NP_955751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon which results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AY169387, BX116021
      Consensus CDS
      CCDS41889.1
      UniProtKB/Swiss-Prot
      Q8N5I3
      Related
      ENSP00000353661.4, ENST00000360473.8
      Conserved Domains (2) summary
      smart00225
      Location:7104
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cl02518
      Location:794
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      50015444..50020922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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