Format

Send to:

Choose Destination
    • Showing Current items.

    CD163L1 CD163 molecule like 1 [ Homo sapiens (human) ]

    Gene ID: 283316, updated on 2-Oct-2018

    Summary

    Official Symbol
    CD163L1provided by HGNC
    Official Full Name
    CD163 molecule like 1provided by HGNC
    Primary source
    HGNC:HGNC:30375
    See related
    Ensembl:ENSG00000177675 MIM:606079; Vega:OTTHUMG00000168325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WC1; M160; CD163B; SCARI2
    Summary
    This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in spleen (RPKM 7.7), small intestine (RPKM 4.5) and 14 other tissues See more
    Orthologs

    Genomic context

    See CD163L1 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (7320510..7444185, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7507556..7596778, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 5 Neighboring gene acyl-CoA synthetase medium chain family member 6 pseudogene Neighboring gene uncharacterized LOC101927882 Neighboring gene acyl-CoA synthetase medium chain family member 4 Neighboring gene M-phase phosphoprotein 8 pseudogene Neighboring gene CD163 molecule Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD163 molecule-like 1 (CD163L1) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    scavenger receptor cysteine-rich type 1 protein M160
    Names
    CD163 antigen B
    CD163 antigen-like 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297650.1NP_001284579.1  scavenger receptor cysteine-rich type 1 protein M160 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131205, AC131206, AC131207, AK303372, BQ024006, DC348327
      Consensus CDS
      CCDS73434.1
      UniProtKB/Swiss-Prot
      Q9NR16
      Related
      ENSP00000393474.2, OTTHUMP00000238591, ENST00000416109.2, OTTHUMT00000399330
      Conserved Domains (2) summary
      smart00202
      Location:10461146
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:10511146
      SRCR; Scavenger receptor cysteine-rich domain
    2. NM_174941.5NP_777601.2  scavenger receptor cysteine-rich type 1 protein M160 isoform 2 precursor

      See identical proteins and their annotated locations for NP_777601.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AF264014, AK058038, BQ024006, DB145231, DC348327
      Consensus CDS
      CCDS8577.1
      UniProtKB/Swiss-Prot
      Q9NR16
      Related
      ENSP00000315945.3, OTTHUMP00000238590, ENST00000313599.7, OTTHUMT00000399329
      Conserved Domains (2) summary
      smart00202
      Location:10361136
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:10411136
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      7320510..7444185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520616.1XP_011518918.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X1

      UniProtKB/Swiss-Prot
      Q9NR16
      Conserved Domains (2) summary
      smart00202
      Location:10361136
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:10411136
      SRCR; Scavenger receptor cysteine-rich domain
    2. XM_011520617.2XP_011518919.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X2

      Conserved Domains (2) summary
      smart00202
      Location:10111111
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:10161111
      SRCR; Scavenger receptor cysteine-rich domain
    3. XM_011520620.1XP_011518922.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X4

      See identical proteins and their annotated locations for XP_011518922.1

      Conserved Domains (2) summary
      smart00202
      Location:765865
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:770865
      SRCR; Scavenger receptor cysteine-rich domain
    4. XM_011520619.1XP_011518921.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X4

      See identical proteins and their annotated locations for XP_011518921.1

      Conserved Domains (2) summary
      smart00202
      Location:765865
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:770865
      SRCR; Scavenger receptor cysteine-rich domain
    5. XM_011520618.3XP_011518920.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X3

      Conserved Domains (2) summary
      smart00202
      Location:797897
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:802897
      SRCR; Scavenger receptor cysteine-rich domain
    6. XM_011520621.3XP_011518923.1  scavenger receptor cysteine-rich type 1 protein M160 isoform X5

      Conserved Domains (2) summary
      smart00202
      Location:349449
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:354449
      SRCR; Scavenger receptor cysteine-rich domain

    RNA

    1. XR_931282.2 RNA Sequence

    2. XR_002957313.1 RNA Sequence

    Support Center