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    COL1A2 collagen type I alpha 2 chain [ Bos taurus (cattle) ]

    Gene ID: 282188, updated on 5-Mar-2024

    Summary

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    Official Symbol
    COL1A2provided by VGNC
    Official Full Name
    collagen type I alpha 2 chainprovided by VGNC
    Primary source
    VGNC:VGNC:27561
    See related
    BGD:BT12259; Ensembl:ENSBTAG00000013472
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (11776417..11813113)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 11 Neighboring gene Bet1 golgi vesicular membrane trafficking protein Neighboring gene uncharacterized LOC132345065 Neighboring gene CAS1 domain containing 1 Neighboring gene sarcoglycan epsilon

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The FAXWXXT motif in the carboxyl terminus of Vibrio mimicus metalloprotease is involved in binding to collagen. Lee JH, et al. FEBS Lett, 2005 Apr 25. PMID 15848196
    2. The complete cDNA coding sequence for the bovine proalpha2(I) chain of type I procollagen. Shirai T, et al. Matrix Biol, 1998 Apr. PMID 9628255
    3. Amino acid sequence of the amino-terminal region of calf skin collagen. Fietzek PP, et al. Biochim Biophys Acta, 1974 Oct 9. PMID 4609475
    4. The covalent structure of collagen. The amino-acid sequence of alpha2-CB4 from calf-skin collagen. Fietzek PP, et al. Eur J Biochem, 1975 Nov 1. PMID 173531
    5. Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, gammadelta (WC1+) T cells and CD 68+ cells. Wangoo A, et al. J Comp Pathol, 2005 Nov. PMID 16154140

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
      Title: Matrix-specific suppression of integrin activation in shear stress signaling.
    2. In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen
      Title: Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, gammadelta (WC1+) T cells and CD 68+ cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    collagen alpha-2(I) chain
    Names
    alpha-2 type I collagen
    collagen 1 alpha 2 chain
    collagen, type I, alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174520.2 → NP_776945.1  collagen alpha-2(I) chain precursor

      See identical proteins and their annotated locations for NP_776945.1

      Status: PROVISIONAL

      Source sequence(s)
      AB008683
      UniProtKB/Swiss-Prot
      A6QP13, O62649, P02465
      Related
      ENSBTAP00000033771.4, ENSBTAT00000033863.6
      Conserved Domains (2) summary
      pfam01391
      Location:545 → 603
      Collagen; Collagen triple helix repeat (20 copies)
      pfam01410
      Location:1132 → 1363
      COLFI; Fibrillar collagen C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      11776417..11813113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059885409.1 → XP_059741392.1  collagen alpha-2(I) chain isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LZN8
      Related
      ENSBTAP00000068079.2, ENSBTAT00000072710.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02465.2 GenPept UniProtKB/Swiss-Prot:P02465

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.