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    RGS17 regulator of G protein signaling 17 [ Homo sapiens (human) ]

    Gene ID: 26575, updated on 12-Aug-2018


    Official Symbol
    RGS17provided by HGNC
    Official Full Name
    regulator of G protein signaling 17provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000091844 MIM:607191; Vega:OTTHUMG00000015858
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGSZ2; RGS-17; hRGS17
    This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
    Broad expression in thyroid (RPKM 1.8), brain (RPKM 1.6) and 17 other tissues See more

    Genomic context

    See RGS17 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (153010891..153131284, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (153332026..153452389, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene F-box protein 5 Neighboring gene mitochondrial translational release factor 1 like Neighboring gene RNA, 5S ribosomal pseudogene 224 Neighboring gene ribosomal protein L27a pseudogene 6

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016


    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?


    NHGRI GWAS Catalog

    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (z) signalling events, organism-specific biosystemThe heterotrimeric G protein Gz, is a member of the Gi family. Unlike other Gi family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information



    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    Process Evidence Code Pubs
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    synapse IEA
    Inferred from Electronic Annotation
    more info

    General protein information

    Preferred Names
    regulator of G-protein signaling 17

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012419.4NP_036551.3  regulator of G-protein signaling 17

      See identical proteins and their annotated locations for NP_036551.3

      Status: REVIEWED

      Source sequence(s)
      AA902430, AF202257, BC013117, CK902282
      Consensus CDS
      ENSP00000206262.1, ENST00000206262.1
      Conserved Domains (1) summary
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly


    1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

      153010891..153131284 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010733.1XP_016866222.1  regulator of G-protein signaling 17 isoform X1

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