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    GAS6 growth arrest specific 6 [ Homo sapiens (human) ]

    Gene ID: 2621, updated on 28-Oct-2019

    Summary

    Official Symbol
    GAS6provided by HGNC
    Official Full Name
    growth arrest specific 6provided by HGNC
    Primary source
    HGNC:HGNC:4168
    See related
    Ensembl:ENSG00000183087 MIM:600441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AXSF; AXLLG
    Summary
    This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in lung (RPKM 64.9), endometrium (RPKM 57.7) and 24 other tissues See more
    Orthologs

    Genomic context

    See GAS6 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (113820549..113864076, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114523522..114567046, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene long intergenic non-protein coding RNA 552 Neighboring gene transmembrane protein 255B Neighboring gene GAS6 antisense RNA 1 Neighboring gene GAS6 divergent transcript Neighboring gene long intergenic non-protein coding RNA 454

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ34709, DKFZp666G247

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    activation of protein kinase B activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic cell clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cycle arrest TAS
    Traceable Author Statement
    more info
    PubMed 
    cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to vitamin K IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    enzyme linked receptor protein signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fusion of virus membrane with host plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hematopoietic stem cell migration to bone marrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of biomineral tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of dendritic cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-1 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-6 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of oligodendrocyte apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of renal albumin absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
    PubMed 
    platelet aggregation TAS
    Traceable Author Statement
    more info
    PubMed 
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glomerular filtration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of natural killer cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein kinase B signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor-mediated virion attachment to host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi lumen TAS
    Traceable Author Statement
    more info
     
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    growth arrest-specific protein 6
    Names
    AXL receptor tyrosine kinase ligand
    AXL stimulatory factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029703.1 RefSeqGene

      Range
      4998..48525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000820.4NP_000811.1  growth arrest-specific protein 6 precursor

      See identical proteins and their annotated locations for NP_000811.1

      Status: REVIEWED

      Source sequence(s)
      AA045119, BC038984, HY038614
      Consensus CDS
      CCDS45072.1
      UniProtKB/Swiss-Prot
      Q14393
      Related
      ENSP00000331831.6, ENST00000327773.7
      Conserved Domains (7) summary
      smart00179
      Location:197227
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:118153
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:298450
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00594
      Location:5392
      Gla; Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
      pfam02210
      Location:513651
      Laminin_G_2; Laminin G domain
      pfam14670
      Location:160195
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:232273
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      113820549..113864076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001143945.1: Suppressed sequence

      Description
      NM_001143945.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_001143946.1: Suppressed sequence

      Description
      NM_001143946.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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