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    KLK13 kallikrein related peptidase 13 [ Homo sapiens (human) ]

    Gene ID: 26085, updated on 23-May-2018
    Official Symbol
    KLK13provided by HGNC
    Official Full Name
    kallikrein related peptidase 13provided by HGNC
    Primary source
    HGNC:HGNC:6361
    See related
    Ensembl:ENSG00000167759 MIM:605505; Vega:OTTHUMG00000182912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KLKL4; KLK-L4
    Summary
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]
    Expression
    Restricted expression toward esophagus (RPKM 227.0) See more
    Orthologs
    See KLK13 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (51055626..51065110, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51559021..51568367, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 11 Neighboring gene kallikrein related peptidase 12 Neighboring gene uncharacterized LOC107985341 Neighboring gene kallikrein related peptidase 14

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp586J1923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cornification TAS
    Traceable Author Statement
    more info
     
    protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Preferred Names
    kallikrein-13
    Names
    kallikrein-like gene 4
    kallikrein-like protein 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348177.1NP_001335106.1  kallikrein-13 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB108824, AC011473, AY923171
      UniProtKB/TrEMBL
      Q5BQ99, Q86VI7
      Related
      ENSP00000470245.1, ENST00000595547.5
      Conserved Domains (1) summary
      cd00190
      Location:38188
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001348178.1NP_001335107.1  kallikrein-13 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB108823, AC011473, AY923171
      UniProtKB/Swiss-Prot
      Q9UKR3
      UniProtKB/TrEMBL
      Q5BQ99
      Related
      ENSP00000334079.3, ENST00000335422.3
      Conserved Domains (1) summary
      cd00190
      Location:16109
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_015596.2NP_056411.1  kallikrein-13 isoform 1 precursor

      See identical proteins and their annotated locations for NP_056411.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC011473, BC069334
      Consensus CDS
      CCDS12822.1
      UniProtKB/Swiss-Prot
      Q9UKR3
      UniProtKB/TrEMBL
      A0A1R3UCE9
      Related
      ENSP00000470555.1, OTTHUMP00000270488, ENST00000595793.5, OTTHUMT00000464298
      Conserved Domains (1) summary
      cd00190
      Location:38261
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RNA

    1. NR_145463.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011473, AY923171
    2. NR_145464.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011473, AY923172
    3. NR_145465.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011473, AY923173
    4. NR_145466.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011473, AY923174
    5. NR_145467.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011473, AY923175

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      51055626..51065110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_935788.1 RNA Sequence

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