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    AMBP alpha-1-microglobulin/bikunin precursor [ Homo sapiens (human) ]

    Gene ID: 259, updated on 17-Jun-2024

    Summary

    Official Symbol
    AMBPprovided by HGNC
    Official Full Name
    alpha-1-microglobulin/bikunin precursorprovided by HGNC
    Primary source
    HGNC:HGNC:453
    See related
    Ensembl:ENSG00000106927 MIM:176870; AllianceGenome:HGNC:453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC
    Summary
    This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward liver (RPKM 2536.6) See more
    Orthologs
    NEW
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    Genomic context

    See AMBP in Genome Data Viewer
    Location:
    9q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (114060127..114078300, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (126258798..126276960, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116822407..116840580, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene programmed cell death 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116636012-116636512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116636513-116637013 Neighboring gene zinc finger protein 618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116697421-116697921 Neighboring gene VISTA enhancer hs641 Neighboring gene Sharpr-MPRA regulatory region 15709 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:116751538-116752038 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:116768395-116768894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116770304-116770804 Neighboring gene uncharacterized LOC107987120 Neighboring gene uncharacterized LOC124902251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116861361-116861896 Neighboring gene kinesin family member 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium channel inhibitor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables calcium oxalate binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables carbohydrate binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in female pregnancy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in heme catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of JNK cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    protein AMBP
    Names
    bikunin
    complex-forming glycoprotein heterogeneous in charge
    growth-inhibiting protein 19
    inter-alpha-trypsin inhibitor light chain
    protein HC
    trypstatin
    uristatin
    uronic-acid-rich protein
    NP_001624.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001633.4NP_001624.1  protein AMBP preproprotein

      See identical proteins and their annotated locations for NP_001624.1

      Status: REVIEWED

      Source sequence(s)
      BC041593
      Consensus CDS
      CCDS6800.1
      UniProtKB/Swiss-Prot
      P00977, P02759, P02760, P78491, Q2TU33, Q5TBD7, Q9UC58, Q9UDI8
      Related
      ENSP00000265132.3, ENST00000265132.8
      Conserved Domains (4) summary
      cd00109
      Location:229282
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:286338
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00061
      Location:42186
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
      cl21528
      Location:2248
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      114060127..114078300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      126258798..126276960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)