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    Alpl alkaline phosphatase, biomineralization associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25586, updated on 10-Jul-2024

    Summary

    Official Symbol
    Alplprovided by RGD
    Official Full Name
    alkaline phosphatase, biomineralization associatedprovided by RGD
    Primary source
    RGD:2100
    See related
    EnsemblRapid:ENSRNOG00000013954 AllianceGenome:RGD:2100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akp2; PHOA; TNAP; TNSALP; AP-TNAP
    Summary
    Enables alkaline phosphatase activity. Involved in cementum mineralization; response to glucocorticoid; and response to lipopolysaccharide. Located in extracellular space and plasma membrane. Is active in extracellular membrane-bounded organelle. Biomarker of uremia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 605.2), Lung (RPKM 229.4) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Alpl in Genome Data Viewer
    Location:
    5q36
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155234770..155289785, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149951397..150006424, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156086496..156141513, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 48 Neighboring gene Rap1 GTPase-activating protein Neighboring gene uncharacterized LOC134487019 Neighboring gene U4 spliceosomal RNA Neighboring gene endothelin converting enzyme 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93545

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alkaline phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alkaline phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alkaline phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoamidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoamidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphoethanolamine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pyrophosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyrophosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cementum mineralization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within developmental process involved in reproduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endochondral ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in futile creatine cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inhibition of non-skeletal tissue mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pyridoxal phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to macrophage colony-stimulating factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to sodium phosphate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to vitamin B6 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to vitamin D ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    alkaline phosphatase, tissue-nonspecific isozyme
    Names
    Tissue-nonspecific ALP alkaline phosphatase
    alkaline phosphatase 2, liver
    alkaline phosphatase liver/bone/kidney isozyme
    alkaline phosphatase, liver/bone/kidney
    phosphoamidase
    phosphocreatine phosphatase
    tissue-nonspecific alkaline phosphatase
    NP_037191.2
    XP_006239198.1
    XP_063143270.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429380.1NP_001416309.1  alkaline phosphatase, tissue-nonspecific isozyme precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P08289, P14055, P70707
      UniProtKB/TrEMBL
      A6ITE7
    2. NM_013059.3NP_037191.2  alkaline phosphatase, tissue-nonspecific isozyme precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P08289, P14055, P70707
      UniProtKB/TrEMBL
      A6ITE7
      Related
      ENSRNOP00000019004.3, ENSRNOT00000019004.7
      Conserved Domains (1) summary
      pfam00245
      Location:51490
      Alk_phosphatase; Alkaline phosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      155234770..155289785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287200.1XP_063143270.1  alkaline phosphatase, tissue-nonspecific isozyme isoform X1

    2. XM_006239136.5XP_006239198.1  alkaline phosphatase, tissue-nonspecific isozyme isoform X1

      See identical proteins and their annotated locations for XP_006239198.1

      UniProtKB/Swiss-Prot
      P08289, P14055, P70707
      UniProtKB/TrEMBL
      A6ITE7
      Conserved Domains (1) summary
      pfam00245
      Location:51490
      Alk_phosphatase; Alkaline phosphatase