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    FUT4 fucosyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 2526, updated on 5-Aug-2018

    Summary

    Official Symbol
    FUT4provided by HGNC
    Official Full Name
    fucosyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:4015
    See related
    Ensembl:ENSG00000196371 MIM:104230; Vega:OTTHUMG00000167795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV
    Summary
    The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
    Orthologs

    Genomic context

    See FUT4 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (94543851..94549898)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94277017..94283064)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MRE11 homolog, double strand break repair nuclease Neighboring gene ankyrin repeat domain 49 Neighboring gene chromosome 11 open reading frame 97 Neighboring gene uncharacterized LOC105369438 Neighboring gene piwi like RNA-mediated gene silencing 4 Neighboring gene uncharacterized LOC105369436

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alpha-(1->3)-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    L-fucose catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fucosylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein glycosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell periphery IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-(1,3)-fucosyltransferase 4
    Names
    ELAM ligand fucosyltransferase
    ELAM-1 ligand fucosyltransferase
    Lewis X
    alpha (1,3) fucosyltransferase, myeloid-specific
    fucT-IV
    fucosyltransferase IV
    galactoside 3-L-fucosyltransferase
    stage-specific embryonic antigen 1
    NP_002024.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002033.3NP_002024.1  alpha-(1,3)-fucosyltransferase 4

      See identical proteins and their annotated locations for NP_002024.1

      Status: REVIEWED

      Source sequence(s)
      AF305083, AP000943, BC136374, BE242611
      Consensus CDS
      CCDS8301.1
      UniProtKB/Swiss-Prot
      P22083
      Related
      ENSP00000351602.2, OTTHUMP00000236888, ENST00000358752.3, OTTHUMT00000396327
      Conserved Domains (2) summary
      pfam00852
      Location:353525
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:186331
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      94543851..94549898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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