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    ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 25, updated on 27-Nov-2024

    Summary

    Official Symbol
    ABL1provided by HGNC
    Official Full Name
    ABL proto-oncogene 1, non-receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:76
    See related
    Ensembl:ENSG00000097007 MIM:189980; AllianceGenome:HGNC:76
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl
    Summary
    This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in endometrium (RPKM 24.7), gall bladder (RPKM 20.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ABL1 in Genome Data Viewer
    Location:
    9q34.12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (130713043..130887675)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (142917999..143092548)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133588430..133763062)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs876 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:133541982-133543181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20403 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133556829-133557504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29155 Neighboring gene PR/SET domain 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29157 Neighboring gene ABL breakpoint recombination region Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133587784-133588460 Neighboring gene uncharacterized LOC128092248 Neighboring gene exosome component 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133604882-133605718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133605719-133606555 Neighboring gene ribosomal protein L37 pseudogene 17 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133635228-133635409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29161 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133642635-133643440 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133643441-133644245 Neighboring gene uncharacterized LOC124902288 Neighboring gene uncharacterized LOC124902287 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133709696-133710222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133710223-133710748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20408 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:133722835-133723457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133735115-133735964 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133735965-133736812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133737874-133738374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133738375-133738875 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:133741863-133742364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29164 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:133756258-133757457 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133759146-133759916 Neighboring gene Sharpr-MPRA regulatory region 3771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133769017-133769531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133770320-133771007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133771008-133771694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133789692-133790384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133794286-133794826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133796861-133797810 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133798030-133798213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133798761-133799708 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene fibrinogen C domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133805119-133805663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133814336-133815266 Neighboring gene FIBCD1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Chronic myelogenous leukemia, BCR-ABL1 positive
    MedGen: C0279543 OMIM: 608232 GeneReviews: Not available
    Compare labs
    Congenital heart defects and skeletal malformations syndrome
    MedGen: C4539857 OMIM: 617602 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Downregulation of the Wave2 signaling complex (Tiam-1, Abl, Rac, IRSp53, Wave2, and Arp3) with siRNA reduces HIV-1 Env-mediated cell-cell fusion and virus-cell fusion PubMed
    Tat tat HIV-1 Tat-mediated inhibition of miR-196a leads to upregulation of p73 and c-ABL protein expression in cells PubMed
    tat HIV-1 Tat 47-59 peptide downregulates gene expression of c-abl oncogene 1, non-receptor tyrosine kinase (ABL1) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin monomer binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables bubble DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables delta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ephrin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables four-way junction DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables neuropilin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nicotinate-nucleotide adenylyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proline-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables proline-rich region binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables supercoiled DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell proliferation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in B-1 B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Bergmann glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DN4 thymocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA conformation change IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of protein kinase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to dopamine TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebellum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in microspike assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mismatch repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitochondrial depolarization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuroepithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropilin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within phospholipase C-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in platelet-derived growth factor receptor-beta signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in podocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of blood vessel branching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of establishment of T cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-2 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to cytoplasmic microtubule plus-end IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein modification process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of Cdc42 protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of hematopoietic stem cell differentiation TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of modification of synaptic structure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynaptic specialization assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to epinephrine IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transitional one stage B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynapse TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase ABL1
    Names
    ABL protooncogene 1 nonreceptor tyrosine kinase
    Abelson tyrosine-protein kinase 1
    BCR-ABL1 p190
    BCR/ABL e8a2 fusion
    BCR/ABL1 e1a2 fusion protein
    BCR/ABL1 fusion
    bcr/c-abl oncogene protein
    c-abl oncogene 1, receptor tyrosine kinase
    chimeric BCR::ABL1 protein
    proto-oncogene c-Abl
    proto-oncogene tyrosine-protein kinase ABL1
    v-abl Abelson murine leukemia viral oncogene homolog 1
    NP_005148.2
    NP_009297.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012034.1 RefSeqGene

      Range
      4163..178795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_769

    mRNA and Protein(s)

    1. NM_005157.6NP_005148.2  tyrosine-protein kinase ABL1 isoform a

      See identical proteins and their annotated locations for NP_005148.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) includes an alternate 5' terminal exon (exon 1a instead of exon 1b), and it thus differs in the 5' UTR and 5' coding region, compared to variant b. The encoded isoform (a), which is localized in the nucleus, has a distinct N-terminus and is shorter than isoform b.
      Source sequence(s)
      AB209456, AI458416, AL161733, M14752, X16416
      Consensus CDS
      CCDS35166.1
      UniProtKB/Swiss-Prot
      A3KFJ3, P00519, Q13869, Q13870, Q16133, Q17R61, Q45F09
      UniProtKB/TrEMBL
      Q59FK4
      Related
      ENSP00000323315.5, ENST00000318560.6
      Conserved Domains (5) summary
      smart00808
      Location:10061130
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:123216
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:65118
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:235497
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:242493
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_007313.3NP_009297.2  tyrosine-protein kinase ABL1 isoform b

      See identical proteins and their annotated locations for NP_009297.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b), which includes exon 1b but not exon 1a, represents the longer transcript and encodes the longer isoform (b). This isoform contains an N-terminal glycine which could be myristylated, and it is thus thought to be directed to the plasma membrane.
      Source sequence(s)
      AA524892, AB209456, AL359092, AL707819, CA335983
      Consensus CDS
      CCDS35165.1
      UniProtKB/TrEMBL
      Q59FK4
      Related
      ENSP00000361423.2, ENST00000372348.9
      Conserved Domains (5) summary
      smart00808
      Location:10251149
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:142235
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:84137
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:254516
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:261512
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      130713043..130887675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      142917999..143092548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)