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    Ptprc protein tyrosine phosphatase, receptor type, C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24699, updated on 10-Oct-2019

    Summary

    Official Symbol
    Ptprcprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Cprovided by RGD
    Primary source
    RGD:3451
    See related
    Ensembl:ENSRNOG00000000655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lca; RT7; CD45; L-CA; T200
    Summary
    member of a family of heavily glycosylated leukocyte cell surface glycoproteins; displays extensive O-glycosylation [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 1284.0), Thymus (RPKM 1219.5) and 4 other tissues See more
    Orthologs

    Genomic context

    See Ptprc in Genome Data Viewer
    Location:
    13q13
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (55061561..55174150, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (60094038..60205773, complement)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene microRNA 181a-1 Neighboring gene microRNA 181b-1 Neighboring gene microRNA 3570 Neighboring gene uncharacterized LOC102548579 Neighboring gene ATPase H+ transporting V1 subunit G3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • EPO Receptor Signaling, organism-specific biosystem (from WikiPathways)
      EPO Receptor Signaling, organism-specific biosystemThe erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activat...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ankyrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heparan sulfate proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    spectrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    T cell receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    bone marrow development IEA
    Inferred from Electronic Annotation
    more info
     
    bone marrow development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium-mediated signaling using intracellular calcium source ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to extracellular stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    immunoglobulin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    natural killer cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of T cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell adhesion involved in substrate-bound cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell adhesion involved in substrate-bound cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-2 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane raft distribution ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of antigen receptor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of antigen receptor-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gamma-delta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of hematopoietic stem cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hematopoietic stem cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of humoral immune response mediated by circulating immunoglobulin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of interleukin-2 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of isotype switching to IgG isotypes ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of JAK-STAT cascade IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of humoral immune response mediated by circulating immunoglobulin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to gamma radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell development IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    bleb IEA
    Inferred from Electronic Annotation
    more info
     
    bleb ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic side of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane microdomain ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase C
    Names
    T200 glycoprotein
    leucocyte common antigen
    leukocyte common antigen A
    leukocyte common antigen B
    protein tyrosine phosphatase, receptor-type, c polypeptide
    NP_001103357.1
    NP_001103358.1
    NP_001103359.1
    NP_001103360.1
    NP_612516.2
    XP_006249972.1
    XP_006249974.1
    XP_008767756.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109887.2NP_001103357.1  receptor-type tyrosine-protein phosphatase C isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 4. The resulting isoform (3) is shorter compared to isoform 4.
      Source sequence(s)
      AABR07021058, AABR07021060
      UniProtKB/Swiss-Prot
      P04157
      Related
      ENSRNOP00000030503.4, ENSRNOT00000029878.6
      Conserved Domains (5) summary
      smart00194
      Location:538797
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:566797
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:283348
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:527
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:120174
      CD45; Leukocyte receptor CD45
    2. NM_001109888.2NP_001103358.1  receptor-type tyrosine-protein phosphatase C isoform 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons compared to variant 4. The resulting isoform (5) is shorter compared to isoform 4.
      Source sequence(s)
      AABR07021058, AABR07021060
      UniProtKB/Swiss-Prot
      P04157
      Related
      ENSRNOP00000029889.4, ENSRNOT00000029865.6
      Conserved Domains (5) summary
      smart00194
      Location:531790
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:559790
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:276341
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:527
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:113167
      CD45; Leukocyte receptor CD45
    3. NM_001109889.2NP_001103359.1  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons compared to variant 4. The resulting isoform (2) is shorter compared to isoform 4.
      Source sequence(s)
      AABR07021058, AABR07021060
      UniProtKB/Swiss-Prot
      P04157
      Related
      ENSRNOP00000057042.2, ENSRNOT00000060292.4
      Conserved Domains (5) summary
      smart00194
      Location:530789
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:558789
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:275340
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:527
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:112166
      CD45; Leukocyte receptor CD45
    4. NM_001109890.2NP_001103360.1  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

      See identical proteins and their annotated locations for NP_001103360.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks three in-frame exons compared to variant 4. The resulting isoform (1) is shorter compared to isoform 4.
      Source sequence(s)
      AABR07021058, AABR07021060
      UniProtKB/Swiss-Prot
      P04157
      Related
      ENSRNOP00000000814.4, ENSRNOT00000000814.4
      Conserved Domains (5) summary
      smart00194
      Location:489748
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:517748
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:234299
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:527
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:71125
      CD45; Leukocyte receptor CD45
    5. NM_138507.3NP_612516.2  receptor-type tyrosine-protein phosphatase C isoform 4 precursor

      See identical proteins and their annotated locations for NP_612516.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AABR07021058, AABR07021060
      UniProtKB/Swiss-Prot
      P04157
      Related
      ENSRNOP00000063859.1, ENSRNOT00000064785.3
      Conserved Domains (5) summary
      smart00194
      Location:621880
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:649880
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:366431
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:527
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:203257
      CD45; Leukocyte receptor CD45

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      55061561..55174150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249910.2XP_006249972.1  receptor-type tyrosine-protein phosphatase C isoform X1

      See identical proteins and their annotated locations for XP_006249972.1

      UniProtKB/Swiss-Prot
      P04157
      Conserved Domains (5) summary
      smart00194
      Location:621880
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:649880
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:366431
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:527
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:203257
      CD45; Leukocyte receptor CD45
    2. XM_006249912.3XP_006249974.1  receptor-type tyrosine-protein phosphatase C isoform X3

      Conserved Domains (6) summary
      PHA03255
      Location:22149
      PHA03255; BDLF3; Provisional
      smart00194
      Location:579838
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:607838
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:324389
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:527
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:161215
      CD45; Leukocyte receptor CD45
    3. XM_008769534.2XP_008767756.1  receptor-type tyrosine-protein phosphatase C isoform X2

      Conserved Domains (6) summary
      PHA03255
      Location:11152
      PHA03255; BDLF3; Provisional
      smart00194
      Location:580839
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:608839
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:325390
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12453
      Location:527
      PTP_N; Protein tyrosine phosphatase N terminal
      pfam12567
      Location:162216
      CD45; Leukocyte receptor CD45

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      49881478..49993142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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