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    Gapdh glyceraldehyde-3-phosphate dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24383, updated on 10-Jul-2024

    Summary

    Official Symbol
    Gapdhprovided by RGD
    Official Full Name
    glyceraldehyde-3-phosphate dehydrogenaseprovided by RGD
    Primary source
    RGD:2661
    See related
    EnsemblRapid:ENSRNOG00000018630 AllianceGenome:RGD:2661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gapd; BARS-38
    Summary
    This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. A similar protein in human and mouse has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies in human and mouse have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins. Many pseudogenes similar to this locus are found throughout the rat genome. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in Muscle (RPKM 152.0), Heart (RPKM 48.5) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gapdh in Genome Data Viewer
    Location:
    4q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159648592..159653436, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157962312..157967158, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157676336..157680322, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene NOP2 nucleolar protein Neighboring gene intermediate filament family orphan 1 Neighboring gene non-SMC condensin I complex, subunit D2 Neighboring gene small Cajal body-specific RNA 10 Neighboring gene mitochondrial ribosomal protein L51

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables aspartic-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidyl-cysteine S-nitrosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidyl-cysteine S-nitrosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical glycolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nitric oxide mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type I interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of GAIT complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of GAIT complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glyceraldehyde-3-phosphate dehydrogenase
    Names
    38 kDa BFA-dependent ADP-ribosylation substrate
    peptidyl-cysteine S-nitrosylase GAPDH
    NP_058704.1
    XP_038962936.1
    XP_063141587.1
    XP_063141588.1
    XP_063141589.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017008.4NP_058704.1  glyceraldehyde-3-phosphate dehydrogenase

      See identical proteins and their annotated locations for NP_058704.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059110
      UniProtKB/Swiss-Prot
      P04797, P09328, Q5M916, Q9QWU4
      UniProtKB/TrEMBL
      A0A8L2QM97, A6ILS6
      Conserved Domains (1) summary
      PLN02272
      Location:2330
      PLN02272; glyceraldehyde-3-phosphate dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159648592..159653436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107008.2XP_038962936.1  glyceraldehyde-3-phosphate dehydrogenase isoform X1

      UniProtKB/Swiss-Prot
      P04797, P09328, Q5M916, Q9QWU4
      UniProtKB/TrEMBL
      A0A8L2QM97, A6ILS6
      Related
      ENSRNOP00000040878.5, ENSRNOT00000050443.6
      Conserved Domains (1) summary
      PLN02272
      Location:2330
      PLN02272; glyceraldehyde-3-phosphate dehydrogenase
    2. XM_063285517.1XP_063141587.1  glyceraldehyde-3-phosphate dehydrogenase isoform X2

      UniProtKB/TrEMBL
      A0A8L2QM97
    3. XM_063285519.1XP_063141589.1  glyceraldehyde-3-phosphate dehydrogenase isoform X3

      UniProtKB/TrEMBL
      E9PTV9
    4. XM_063285518.1XP_063141588.1  glyceraldehyde-3-phosphate dehydrogenase isoform X3

      UniProtKB/TrEMBL
      E9PTV9