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    Calm3 calmodulin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24244, updated on 9-Oct-2018

    Summary

    Official Symbol
    Calm3provided by RGD
    Official Full Name
    calmodulin 3provided by RGD
    Primary source
    RGD:2259
    See related
    Ensembl:ENSRNOG00000016770
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cam3; Camc; CaMIII; RNCAMIII
    Summary
    putative calmodulin protein expressed predominantly in skeletal muscle and brain [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 5620.8), Muscle (RPKM 1913.6) and 9 other tissues See more
    Orthologs

    Genomic context

    See Calm3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78844520..78851628, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (80092078..80099186, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 8 Neighboring gene prostaglandin I2 receptor Neighboring gene PNMA family member 8B Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene PNMA family member 8A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    N-terminal myristoylation domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    N-terminal myristoylation domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium channel inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    disordered domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    nitric-oxide synthase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nitric-oxide synthase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    titin binding IEA
    Inferred from Electronic Annotation
    more info
     
    titin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    activation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization to mitochondrial membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ryanodine-sensitive calcium-release channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation by host of symbiont cAMP-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation by host of symbiont cAMP-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of high voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ryanodine-sensitive calcium-release channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ryanodine-sensitive calcium-release channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of store-operated calcium channel activity IC
    Inferred by Curator
    more info
    PubMed 
    regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic complex IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic complex ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrial membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    sarcomere IEA
    Inferred from Electronic Annotation
    more info
     
    sarcomere ISO
    Inferred from Sequence Orthology
    more info
     
    spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with synaptic vesicle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calmodulin-3
    Names
    Calmodulin III
    caM
    NP_036650.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012518.3NP_036650.1  calmodulin-3

      See identical proteins and their annotated locations for NP_036650.1

      Status: PROVISIONAL

      Source sequence(s)
      M16659
      UniProtKB/Swiss-Prot
      P0DP29, P0DP30, P0DP31
      Related
      ENSRNOP00000022603.5, ENSRNOT00000022603.5
      Conserved Domains (1) summary
      PTZ00184
      Location:1149
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      78844520..78851628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      72075982..72079075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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