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    Grem1 gremlin 1, DAN family BMP antagonist [ Mus musculus (house mouse) ]

    Gene ID: 23892, updated on 5-Aug-2018

    Summary

    Official Symbol
    Grem1provided by MGI
    Official Full Name
    gremlin 1, DAN family BMP antagonistprovided by MGI
    Primary source
    MGI:MGI:1344337
    See related
    Ensembl:ENSMUSG00000074934 Vega:OTTMUSG00000014814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ld; Drm; Grem; Cktsf1b1
    Expression
    Biased expression in colon adult (RPKM 25.4), large intestine adult (RPKM 20.1) and 8 other tissues See more
    Orthologs

    Genomic context

    See Grem1 in Genome Data Viewer
    Location:
    2 E4; 2 57.43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (113748674..113758785, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (113588832..113598805, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 5B Neighboring gene formin 1 Neighboring gene RIKEN cDNA 4930533B01 gene Neighboring gene predicted gene, 46756 Neighboring gene secretogranin V Neighboring gene Rho GTPase activating protein 11A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (5)  1 citation
    • Radiation induced (1) 

    Pathways from BioSystems

    • Lung fibrosis, organism-specific biosystem (from WikiPathways)
      Lung fibrosis, organism-specific biosystem(Nanoparticle) induced lung fibrosis pathway. Under construction. Note! Mouse homologues for SERPINA1 and SFTPA2 are missing and the pathway currently contains the human equivalents. Other users are ...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    BMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparan sulfate proteoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor ligand activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular endothelial growth factor receptor 2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
     
    determination of dorsal identity ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    limb development ISO
    Inferred from Sequence Orthology
    more info
     
    mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone mineralization involved in bone maturation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone trabecula formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of leukocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoclast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NIK/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT regulation of stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT signal transduction by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ureteric bud formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gremlin-1
    Names
    cysteine knot superfamily 1, BMP antagonist 1
    down-regulated in Mos-transformed cells protein
    down-regulated in v-mos-transformed cells

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011824.4NP_035954.1  gremlin-1 precursor

      See identical proteins and their annotated locations for NP_035954.1

      Status: VALIDATED

      Source sequence(s)
      AL772405
      Consensus CDS
      CCDS16560.1
      UniProtKB/Swiss-Prot
      O70326
      UniProtKB/TrEMBL
      Q3TNY7
      Related
      ENSMUSP00000097170.3, OTTMUSP00000015694, ENSMUST00000099575.3, OTTMUST00000035164
      Conserved Domains (1) summary
      pfam03045
      Location:76179
      DAN; DAN domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      113748674..113758785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499444.3XP_006499507.1  gremlin-1 isoform X1

      See identical proteins and their annotated locations for XP_006499507.1

      UniProtKB/TrEMBL
      Q3UY25
      Conserved Domains (1) summary
      pfam03045
      Location:132235
      DAN; DAN domain
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