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    Akt3 thymoma viral proto-oncogene 3 [ Mus musculus (house mouse) ]

    Gene ID: 23797, updated on 13-Oct-2020

    Summary

    Official Symbol
    Akt3provided by MGI
    Official Full Name
    thymoma viral proto-oncogene 3provided by MGI
    Primary source
    MGI:MGI:1345147
    See related
    Ensembl:ENSMUSG00000019699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nmf35; Nmf350; AI851531; D930002M15Rik
    Expression
    Broad expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 10.5) and 22 other tissues See more
    Orthologs

    Genomic context

    See Akt3 in Genome Data Viewer
    Location:
    1; 1 H4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (176847642..177091688, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177020076..177261781, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (178952246..179178898, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene high mobility group protein HMGI-C-like Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene high mobility group AT-hook 2, pseudogene 1 Neighboring gene predicted gene 15423 Neighboring gene predicted gene, 36904 Neighboring gene zinc finger and BTB domain containing 18 Neighboring gene keratin 8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial genome maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    RAC-gamma serine/threonine-protein kinase
    Names
    PKB gamma
    RAC-PK-gamma
    protein kinase Akt-3
    protein kinase B gamma
    NP_035915.3
    XP_006496881.1
    XP_006496882.1
    XP_011237107.1
    XP_030109770.1
    XP_030109777.1
    XP_036020522.1
    XP_036020523.1
    XP_036020524.1
    XP_036020525.1
    XP_036020526.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011785.4NP_035915.3  RAC-gamma serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_035915.3

      Status: VALIDATED

      Source sequence(s)
      AC130843, AC163009, AK052953, BF455585, CD578931
      Consensus CDS
      CCDS35799.1
      UniProtKB/Swiss-Prot
      Q9WUA6
      UniProtKB/TrEMBL
      Q8C6X4
      Related
      ENSMUSP00000106790.2, ENSMUST00000111160.8
      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      176847642..177091688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164629.1XP_036020522.1  RAC-gamma serine/threonine-protein kinase isoform X3

    2. XM_006496818.5XP_006496881.1  RAC-gamma serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006496881.1

      UniProtKB/Swiss-Prot
      Q9WUA6
      Related
      ENSMUSP00000106789.1
      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    3. XM_036164632.1XP_036020525.1  RAC-gamma serine/threonine-protein kinase isoform X7

    4. XM_036164631.1XP_036020524.1  RAC-gamma serine/threonine-protein kinase isoform X6

    5. XM_036164630.1XP_036020523.1  RAC-gamma serine/threonine-protein kinase isoform X5

    6. XM_030253917.2XP_030109777.1  RAC-gamma serine/threonine-protein kinase isoform X4

    7. XM_030253910.1XP_030109770.1  RAC-gamma serine/threonine-protein kinase isoform X1

      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    8. XM_036164633.1XP_036020526.1  RAC-gamma serine/threonine-protein kinase isoform X7

    9. XM_006496819.5XP_006496882.1  RAC-gamma serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006496882.1

      UniProtKB/Swiss-Prot
      Q9WUA6
      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    10. XM_011238805.4XP_011237107.1  RAC-gamma serine/threonine-protein kinase isoform X2

      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cl21453
      Location:152417
      PKc_like; Protein Kinases, catalytic domain
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