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    IL17RA interleukin 17 receptor A [ Homo sapiens (human) ]

    Gene ID: 23765, updated on 5-Aug-2018

    Summary

    Official Symbol
    IL17RAprovided by HGNC
    Official Full Name
    interleukin 17 receptor Aprovided by HGNC
    Primary source
    HGNC:HGNC:5985
    See related
    Ensembl:ENSG00000177663 MIM:605461; Vega:OTTHUMG00000150026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
    Summary
    Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 11.6), appendix (RPKM 5.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See IL17RA in Genome Data Viewer
    Location:
    22q11.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (17084959..17115694)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (17565849..17596584)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 9 pseudogene Neighboring gene cat eye syndrome chromosome region, candidate 7 Neighboring gene ribosomal protein L31 pseudogene 62 Neighboring gene transmembrane protein 121B Neighboring gene long intergenic non-protein coding RNA 1664

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Immunodeficiency 51
    MedGen: C3151402 OMIM: 613953 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
      IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • IL-17 signaling pathway, conserved biosystem (from KEGG)
      IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
      IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-17 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-17 signaling, organism-specific biosystemInterleukin-17 (IL17) is a family of cytokines (Kawaguchi et al. 2004, Gu et al. 2013). IL17A, the founding member of the family, member of this family, is able to induce the production of other cyt...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: CECR7

    Homology

    Clone Names

    • FLJ32274, FLJ36453, MGC10262

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    interleukin-17 receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    granulocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-17-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-13 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-23 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-5 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-17 receptor A
    Names
    IL-17 receptor A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028257.1 RefSeqGene

      Range
      4999..35734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_355

    mRNA and Protein(s)

    1. NM_001289905.1NP_001276834.1  interleukin-17 receptor A isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes a soluble isoform, isoform 2 which is shorter and lacks a transmembrane region, when compared to isoform 1.
      Source sequence(s)
      AC006946, BX368715, BX410574
      Consensus CDS
      CCDS77645.1
      UniProtKB/Swiss-Prot
      Q96F46
      Related
      ENSP00000479970.1, ENST00000612619.1
      Conserved Domains (3) summary
      pfam08357
      Location:344502
      SEFIR; SEFIR domain
      pfam16556
      Location:48198
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:199303
      IL17R_fnIII_D2; Interleukin 17 receptor D
    2. NM_014339.6NP_055154.3  interleukin-17 receptor A isoform 1 precursor

      See identical proteins and their annotated locations for NP_055154.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC006946, BU585070, BX334547, CB044543, U58917
      Consensus CDS
      CCDS13739.1
      UniProtKB/Swiss-Prot
      Q96F46
      Related
      ENSP00000320936.6, OTTHUMP00000196018, ENST00000319363.10, OTTHUMT00000315820
      Conserved Domains (3) summary
      pfam08357
      Location:378536
      SEFIR; SEFIR domain
      pfam16556
      Location:48198
      IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1
      pfam16578
      Location:199303
      IL17R_fnIII_D2; Interleukin 17 receptor D

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

      Range
      17084959..17115694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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