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    ARFIP2 ADP ribosylation factor interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 23647, updated on 6-Nov-2022

    Summary

    Official Symbol
    ARFIP2provided by HGNC
    Official Full Name
    ADP ribosylation factor interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17160
    See related
    Ensembl:ENSG00000132254 MIM:601638; AllianceGenome:HGNC:17160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POR1
    Summary
    Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin cytoskeleton organization. Located in cell cortex; ruffle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in prostate (RPKM 12.1), thyroid (RPKM 9.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARFIP2 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6476519..6481331, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6534991..6539803, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6497749..6502561, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hemopexin Neighboring gene tripartite motif containing 3 Neighboring gene Sharpr-MPRA regulatory region 6512 Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene voltage dependent anion channel 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ18046, FLJ18697, FLJ99239

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables membrane curvature sensor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in ruffle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    arfaptin-2
    Names
    partner of RAC1 (arfaptin 2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242854.3NP_001229783.1  arfaptin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Consensus CDS
      CCDS73250.1
      UniProtKB/TrEMBL
      A0A087X1E4, B4DUZ3
      Related
      ENSP00000484121.1, ENST00000614314.4
      Conserved Domains (1) summary
      cd07660
      Location:169356
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    2. NM_001242855.3NP_001229784.1  arfaptin-2 isoform 3

      See identical proteins and their annotated locations for NP_001229784.1

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Consensus CDS
      CCDS55740.1
      UniProtKB/Swiss-Prot
      P53365
      Related
      ENSP00000398375.2, ENST00000423813.6
      Conserved Domains (1) summary
      cd07660
      Location:98285
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    3. NM_001242856.3NP_001229785.1  arfaptin-2 isoform 4

      See identical proteins and their annotated locations for NP_001229785.1

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Consensus CDS
      CCDS55739.1
      UniProtKB/Swiss-Prot
      P53365
      Related
      ENSP00000391427.2, ENST00000445086.6
      Conserved Domains (1) summary
      cd07660
      Location:51238
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    4. NM_001370406.2NP_001357335.1  arfaptin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:136322
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    5. NM_001370408.2NP_001357337.1  arfaptin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Consensus CDS
      CCDS55740.1
      Conserved Domains (1) summary
      cd07660
      Location:98285
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    6. NM_001370409.2NP_001357338.1  arfaptin-2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:136318
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    7. NM_001370411.2NP_001357340.1  arfaptin-2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:136318
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    8. NM_001370412.2NP_001357341.1  arfaptin-2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:120307
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    9. NM_001370413.2NP_001357342.1  arfaptin-2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:120307
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    10. NM_001376558.2NP_001363487.1  arfaptin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Consensus CDS
      CCDS7765.1
      UniProtKB/Swiss-Prot
      D3DQT5
      Related
      ENSP00000379998.3, ENST00000396777.8
      Conserved Domains (1) summary
      cd07660
      Location:136323
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    11. NM_001376559.2NP_001363488.1  arfaptin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:136322
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    12. NM_001376560.2NP_001363489.1  arfaptin-2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:136321
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    13. NM_001376561.2NP_001363490.1  arfaptin-2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:136290
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    14. NM_001376562.2NP_001363491.1  arfaptin-2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:108295
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    15. NM_001376563.2NP_001363492.1  arfaptin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Consensus CDS
      CCDS55740.1
      Conserved Domains (1) summary
      cd07660
      Location:98285
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    16. NM_001376564.2NP_001363493.1  arfaptin-2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Conserved Domains (1) summary
      cd07660
      Location:98284
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    17. NM_012402.5NP_036534.1  arfaptin-2 isoform 2

      See identical proteins and their annotated locations for NP_036534.1

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Consensus CDS
      CCDS7765.1
      UniProtKB/Swiss-Prot
      D3DQT5, P53365
      UniProtKB/TrEMBL
      B4DXH2
      Related
      ENSP00000254584.2, ENST00000254584.6
      Conserved Domains (1) summary
      cd07660
      Location:136323
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    RNA

    1. NR_163423.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084337
      Related
      ENST00000531037.5
    2. NR_163424.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084337
    3. NR_164825.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084337
    4. NR_164826.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC084337

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      6476519..6481331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426687.1XP_047282643.1  arfaptin-2 isoform X1

      Conserved Domains (1) summary
      cd07660
      Location:136290
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      6534991..6539803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)